{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:32:14Z","timestamp":1773153134392,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.jaci.2007.09.033","type":"journal-article","created":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T03:28:42Z","timestamp":1196479722000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mycobacterium bovis BCG killed by extended freeze-drying reduces airway hyperresponsiveness in 2 animal models"],"prefix":"10.1016","volume":"121","author":[{"given":"Micheline","family":"Lagranderie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Abolhassani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Vanoirbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Lefort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Anne","family":"Nahori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose-Roberto","family":"Lapa e Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Huerre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Vargaftig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Marchal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2007.09.033_bib1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1164\/ajrccm.161.5.9903102","article-title":"From bronchoconstriction to airways inflammation and remodeling","volume":"161","author":"Bousquet","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.09.033_bib2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0952-7915(00)00155-2","article-title":"The influence of infections on the development and severity of allergic disorders","volume":"12","author":"Herz","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2007.09.033_bib3","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1046\/j.1365-2222.2000.00803.x","article-title":"Early BCG vaccination and reduction in atopy in Guinea-Bissau","volume":"30","author":"Aaby","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.09.033_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.275.5296.77","article-title":"The inverse association between tuberculin responses and atopic disorder","volume":"275","author":"Shirakawa","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jaci.2007.09.033_bib5","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.4049\/jimmunol.168.5.2516","article-title":"Airway hyperresponsiveness, late allergic response, and eosinophilia are reversed with mycobacterial antigens in ovalbumin-presensitized mice","volume":"168","author":"Hopfenspirger","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.09.033_bib6","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/S0264-410X(00)00345-5","article-title":"Effects of Mycobacterium bovis BCG on the development of allergic inflammation and bronchial hyperresponsiveness in hyper-IgE BP2 mice vaccinated as newborns","volume":"19","author":"Nahori","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2007.09.033_bib7","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/S0264-410X(01)00496-0","article-title":"Application of heat killed Mycobacterium bovis-BCG into the lung inhibits the development of allergen-induced Th2 responses","volume":"20","author":"Major","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2007.09.033_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.1365-2567.1998.00432.x","article-title":"Inhibition of an established allergic response to ovalbumin in BALB\/c mice by killed Mycobacterium vaccae","volume":"93","author":"Wang","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2007.09.033_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2222.2003.01612.x","article-title":"Extended freeze-dried Mycobacterium bovis BCG induces the release of IL-12 but not TNF-\u03b1 by alveolar macrophages, both in vitro and in vivo","volume":"33","author":"Hubeau","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.09.033_bib10","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1164\/ajrccm.163.6.2003050","article-title":"The effect of delipidated deglycolipidated (DDMV) and heat-killed Mycobacterium vaccae in asthma","volume":"163","author":"Shirtcliffe","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.09.033_bib11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/419449a","article-title":"Acrylamide from Maillard reaction products","volume":"419","author":"Stadler","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2007.09.033_bib12","first-page":"191","article-title":"The effects of dispersed or surface-grown cultures, manufacture and control methods on BCG standardization","volume":"58A","author":"Gheorghiu","year":"1986","journal-title":"Dev Biol Stand"},{"key":"10.1016\/j.jaci.2007.09.033_bib13","doi-asserted-by":"crossref","first-page":"L207","DOI":"10.1152\/ajplung.00157.2005","article-title":"Immunological determinants of ventilatory changes induced in mice by dermal sensitization and respiratory challenge with toluene diisocyanate","volume":"292","author":"Tarkowski","year":"2007","journal-title":"Am J Physiol Lung Cell mol Physiol"},{"key":"10.1016\/j.jaci.2007.09.033_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2567.2003.01609.x","article-title":"Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production","volume":"108","author":"Lagranderie","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2007.09.033_bib15","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1165\/ajrcmb.20.5.3446","article-title":"Mucous-cell metaplasia and inflammatory-cell recruitment are dissociated in allergic mice after antibody- and drug-dependent cell depletion in a murine model of asthma","volume":"20","author":"Haile","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2007.09.033_bib16","doi-asserted-by":"crossref","first-page":"12290","DOI":"10.1073\/pnas.92.26.12290","article-title":"Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness","volume":"92","author":"Eum","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.09.033_bib17","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1073\/pnas.83.11.3977","article-title":"Control of hemopoiesis in mice by sensitized L3T4+ Lyt2-lymphocytes during infection with bacillus Calmette-Guerin","volume":"83","author":"Marchal","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.09.033_bib18","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1073\/pnas.72.9.3666","article-title":"An endotoxin-induced serum factor that causes necrosis of tumors (activated macrophage)","volume":"72","author":"Carswell","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.09.033_bib19","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1164\/ajrccm.159.3.9805103","article-title":"Expired nitric oxide and airway obstruction in asthma patients with an acute exacerbation","volume":"159","author":"Crater","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.09.033_bib20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nm0602-625","article-title":"Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells","volume":"8","author":"Zuany-Amorim","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2007.09.033_bib21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0091-6749(03)01869-4","article-title":"Regulatory T cells control the development of allergic disease and asthma","volume":"112","author":"Umetsu","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.09.033_bib22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2222.1996.tb00571.x","article-title":"Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids","volume":"26","author":"Moller","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.09.033_bib23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1172\/JCI8107","article-title":"Myeloid dendritic cells induce Th2 responses to inhaled antigens, leading to eosinophilic airway inflammation","volume":"106","author":"Lambrecht","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2007.09.033_bib24","first-page":"107","article-title":"BCG complications: estimates of the risks among vaccinated subjects and statistical analysis of their main characteristics","volume":"21","author":"Lotte","year":"1984","journal-title":"Adv Tuberc Res"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907018271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907018271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:12:46Z","timestamp":1758777166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907018271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0091674907018271"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.09.033","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mycobacterium bovis BCG killed by extended freeze-drying reduces airway hyperresponsiveness in 2 animal models","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}