{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:00:51Z","timestamp":1776060051369,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.jaci.2007.10.011","type":"journal-article","created":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T03:28:42Z","timestamp":1196479722000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids"],"prefix":"10.1016","volume":"121","author":[{"given":"Kittipong","family":"Maneechotesuwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirinya","family":"Supawita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanda","family":"Kasetsinsombat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adisak","family":"Wongkajornsilp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2007.10.011_bib1","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1126\/science.1073514","article-title":"Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase","volume":"297","author":"Munn","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jaci.2007.10.011_bib2","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.189.9.1363","article-title":"Inhibition of T cell proliferation by macrophage tryptophan catabolism","volume":"189","author":"Munn","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2007.10.011_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/83183","article-title":"Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy","volume":"2","author":"Mellor","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2007.10.011_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1084\/jem.20020052","article-title":"Inhibition of\u00a0allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic\u00a0cells: mediation of suppression by tryptophan metabolites","volume":"196","author":"Terness","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2007.10.011_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bbrc.2005.08.232","article-title":"Indoleamine 2,3 dioxygenase and regulation of T cell immunity","volume":"338","author":"Mellor","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2007.10.011_bib6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1172\/JCI21275","article-title":"Inhibition of experimental asthma by indoleamine 2,3-dioxygenase","volume":"114","author":"Hayashi","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2007.10.011_bib7","unstructured":"Global Initiative for Asthma. Asthma management and prevention program. Global Strategy for Asthma Management and Prevention (updated 2006). Available at: http:\/\/www.ginasthma.org. Accessed November 14, 2007."},{"key":"10.1016\/j.jaci.2007.10.011_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.7326\/0003-4819-139-5_Part_1-200309020-00012","article-title":"How do corticosteroids work in asthma?","volume":"139","author":"Barnes","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaci.2007.10.011_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1067\/mai.2003.97","article-title":"Update on glucocorticoid action and resistance","volume":"111","author":"Leung","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.10.011_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1164\/ajrccm.153.2.8564096","article-title":"Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa","volume":"153","author":"Bentley","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.10.011_bib11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1164\/ajrccm\/148.2.401","article-title":"Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression","volume":"148","author":"Robinson","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2007.10.011_bib12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1164\/ajrccm.157.1.9703079","article-title":"Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma","volume":"157","author":"John","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.10.011_bib13","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1398-9995.1998.tb03821.x","article-title":"Alveolar macrophage interleukin (IL)-10 and IL-12 production in atopic asthma","volume":"53","author":"Magnan","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2007.10.011_bib14","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1378\/chest.128.4.1936","article-title":"Formoterol attenuates neutrophilic airway inflammation in asthma","volume":"128","author":"Maneechotesuwan","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2007.10.011_bib15","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1164\/rccm.200408-1041OC","article-title":"Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy","volume":"172","author":"Usmani","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.10.011_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0021-9673(00)89443-1","article-title":"Rapid separation of tryptophan, kynurenines, and indoles using reversed-phase high-performance liquid chromatography","volume":"175","author":"Yong","year":"1979","journal-title":"J Chromatogr"},{"key":"10.1016\/j.jaci.2007.10.011_bib17","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0091-6749(96)70197-5","article-title":"Interleukin-10 regulation in normal subjects and patients with asthma","volume":"97","author":"Borish","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.10.011_bib18","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.molimm.2005.06.022","article-title":"Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy","volume":"43","author":"Raitala","year":"2006","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2007.10.011_bib19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.20020121","article-title":"Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase","volume":"196","author":"Frumento","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2007.10.011_bib20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1074-7613(03)00028-1","article-title":"At the innate frontiers between mother and fetus: linking abortion with complement activation","volume":"18","author":"Caucheteux","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2007.10.011_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/pupt.2000.0318","article-title":"Histamine and serotonin","volume":"14","author":"Barnes","year":"2001","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jaci.2007.10.011_bib22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1183\/09031936.02.00283202","article-title":"Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids","volume":"19","author":"Barnes","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2007.10.011_bib23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1365-2222.2004.01984.x","article-title":"Asymptomatic atopy is associated with increased indoleamine 2,3-dioxygenase activity and interleukin-10 production during seasonal allergen exposure","volume":"34","author":"von Bubnoff","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.10.011_bib24","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2007.10.011_bib25","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2005.03.013","article-title":"GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase","volume":"22","author":"Munn","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2007.10.011_bib26","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.4049\/jimmunol.173.10.5909","article-title":"Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase","volume":"173","author":"Odemuyiwa","year":"2004","journal-title":"J Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907019537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907019537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:11:50Z","timestamp":1758777110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907019537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0091674907019537"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.10.011","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}