{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:43:18Z","timestamp":1771332198604,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.jaci.2007.11.010","type":"journal-article","created":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T10:33:59Z","timestamp":1199702039000},"page":"519-526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Safety and effectiveness of immunotherapy in patients with indolent systemic mastocytosis presenting with Hymenoptera venom anaphylaxis"],"prefix":"10.1016","volume":"121","author":[{"given":"David Gonz\u00e1lez","family":"de Olano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"\u00c1lvarez-Twose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda I.","family":"Esteban-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"S\u00e1nchez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda D. Alonso D\u00edaz","family":"de Durana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arantza","family":"Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Garc\u00eda-Montero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloina","family":"Gonz\u00e1lez-Mancebo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Belver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda D.","family":"Herrero-Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Fern\u00e1ndez-Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"de la Hoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana C.","family":"Castells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Escribano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2007.11.010_bib1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1365-2222.2007.02804.x","article-title":"Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain. A Study of the Spanish Network on Mastocytosis (REMA)","volume":"37","author":"Gonz\u00e1lez de Olano","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.11.010_bib2","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.1016\/S0091-6749(03)80711-X","article-title":"Occult bone marrow mastocytosis presenting as recurrent systemic anaphylaxis","volume":"111","author":"Akin","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000083954","article-title":"Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes","volume":"136","author":"Florian","year":"2005","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000096442","article-title":"Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: monoclonal mast cell activation syndrome","volume":"142","author":"Sonneck","year":"2007","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib5","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1046\/j.1365-2222.2003.01755.x","article-title":"Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy","volume":"33","author":"Haeberli","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.11.010_bib6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(00)03647-3","article-title":"Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings","volume":"357","author":"Ludolph-Hauser","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.11.010_bib7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0091-6749(00)90092-7","article-title":"Survey of patients after discontinuing venom immunotherapy","volume":"105","author":"Golden","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0091-6749(97)70188-X","article-title":"Hymenoptera sting anaphylaxis and urticaria pigmentosa: clinical findings and results of venom immunotherapy in ten patients","volume":"100","author":"Fricker","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib9","first-page":"316","article-title":"Triptasa s\u00e9rica en pacientes al\u00e9rgicos a veneno de himen\u00f3pteros","volume":"19","author":"Esteban","year":"2004","journal-title":"Alergol e Inmunol Clin"},{"key":"10.1016\/j.jaci.2007.11.010_bib10","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0091-6749(94)90213-5","article-title":"Rush hymenoptera venom immunotherapy: successful treatment in a patient with systemic mast cell disease","volume":"94","author":"Engler","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0091-6749(97)70314-2","article-title":"Fatal anaphylaxis after a yellow jacket sting, despite venom immunotherapy, in two patients with mastocytosis","volume":"99","author":"Elberink","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/01.all.0000136756.20701.f8","article-title":"Mastocytosis and hymenoptera allergy","volume":"4","author":"Dubois","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib13","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1046\/j.1365-2222.1998.00411.x","article-title":"Bee sting allergy in beekeepers","volume":"28","author":"Eich-Wanger","year":"1998","journal-title":"Clin Exp Allergy"},{"issue":"suppl 14","key":"10.1016\/j.jaci.2007.11.010_bib14","first-page":"36","volume":"48","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2007.11.010_bib15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1398-9995.1979.tb02006.x","article-title":"Immunotherapy in bee sting hypersensitivity: bee venom versus whole body extract","volume":"34","author":"M\u00fcller","year":"1979","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2007.11.010_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0145-2126(01)00041-8","article-title":"Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis","volume":"25","author":"Sperr","year":"2001","journal-title":"Leuk Res"},{"key":"10.1016\/j.jaci.2007.11.010_bib17","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/00000478-199809000-00013","article-title":"Diagnostic value of immunostaining for tryptase in patients with mastocytosis","volume":"22","author":"Horny","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaci.2007.11.010_bib18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0145-2126(01)00021-2","article-title":"Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings","volume":"25","author":"Horny","year":"2001","journal-title":"Leuk Res"},{"key":"10.1016\/j.jaci.2007.11.010_bib19","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1182\/blood.V91.8.2731.2731_2731_2736","article-title":"Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications","volume":"91","author":"Escribano","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2007.11.010_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.b.10072","article-title":"Immunophenotypic analysis of mast cells in mastocytosis: when and how to do it. Proposals of the Spanish network on mastocytosis (REMA)","volume":"58B","author":"Escribano","year":"2004","journal-title":"Cytometry"},{"key":"10.1016\/j.jaci.2007.11.010_bib21","first-page":"677","article-title":"One-step detection of c-kit point mutations using PNA-mediated PCR-clamping and hybridization probes","volume":"81","author":"Sotlar","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2007.11.010_bib22","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1182\/blood-2006-04-015545","article-title":"KIT mutation in mast cells and other bone marrow haematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients","volume":"108","author":"Garcia-Montero","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2007.11.010_bib23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1034\/j.1600-065X.2001.790108.x","article-title":"Variable expression of activation-linked surface antigens on human mast cells in health and disease","volume":"179","author":"Valent","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2007.11.010_bib24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0145-2126(01)00038-8","article-title":"Diagnostic criteria and classification of mastocytosis: a consensus proposal","volume":"25","author":"Valent","year":"2001","journal-title":"Leuk Res"},{"key":"10.1016\/j.jaci.2007.11.010_bib25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2362.2007.01807.x","article-title":"Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria","volume":"37","author":"Valent","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jaci.2007.11.010_bib26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/01.all.0000235903.10548.63","article-title":"Mastocytosis and Hymenoptera venom allergy","volume":"6","author":"Ru\u00ebff","year":"2006","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib27","first-page":"175","article-title":"Anaphylaxis to insect sting associated with urticaria pigmentosa","volume":"24","author":"Kim","year":"2003","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaci.2007.11.010_bib28","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0091-6749(98)70264-7","article-title":"Sting anaphylaxis and urticaria pigmentosa","volume":"101","author":"Wein","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib29","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0091-6749(83)90630-9","article-title":"Anaphylaxis after Hymenoptera sting in three patients with urticaria pigmentosa","volume":"72","author":"M\u00fcller","year":"1983","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib30","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1182\/blood-2006-06-028100","article-title":"Demonstration of an aberrant mast cell population with clonal markers in a subset of patients with \u201cidiopathic\u201d anaphylaxis","volume":"110","author":"Akin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2007.11.010_bib31","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(00)04677-8","article-title":"Hymenoptera stings and serum tryptase","volume":"357","author":"Krishna","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.11.010_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2796.1993.tb00984.x","article-title":"Anaphylactoid shock following Hymenoptera sting as a presenting symptom of systemic mastocytosis","volume":"233","author":"Kors","year":"1993","journal-title":"J Internal Med"},{"key":"10.1016\/j.jaci.2007.11.010_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/01.all.0000136760.43571.f2","article-title":"Distribution of vespid species in Europe","volume":"4","author":"Fern\u00e1ndez","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib34","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1398-9995.2006.01077.x","article-title":"European Polistes venom allergy","volume":"61","author":"Severino","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2007.11.010_bib35","series-title":"Sesiones Interhospitalarias","first-page":"247","article-title":"Reacci\u00f3n anafil\u00e1ctica: forma de presentaci\u00f3n de una enfermedad rara","author":"Sierra","year":"2003"},{"key":"10.1016\/j.jaci.2007.11.010_bib36","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1034\/j.1398-9995.2000.00587.x","article-title":"Side-effects of insect venom immunotherapy: results from an EAACI multicenter study. European Academy of Allergology and Clinical Immunology","volume":"55","author":"Mosbech","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2007.11.010_bib37","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0091-6749(97)70271-9","article-title":"Discontinuation of yellow jacket venom immunotherapy: follow-up of 75 patients by means of deliberate sting challenge","volume":"100","author":"van Halteren","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF01533368","article-title":"Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis","volume":"14","author":"Schwartz","year":"1994","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib39","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0091-6749(86)90418-5","article-title":"Guidelines for venom immunotherapy","volume":"77","author":"Golden","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib40","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.jaci.2007.03.032","article-title":"Omalizumab for the treatment of unprovoked anaphylaxis in patients with systemic mastocytosis","volume":"119","author":"Carter","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jaci.2005.01.005","article-title":"Insect sting allergy and venom immunotherapy: a model and a mystery","volume":"115","author":"Golden","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib42","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0091-6749(93)90007-3","article-title":"Selection of Hymenoptera venoms for immunotherapy on the basis of patient's IgE antibody cross-reactivity","volume":"92","author":"Hamilton","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib43","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000024453","article-title":"Double sensitization to honeybee and wasp venom: immunotherapy with one or with both venoms?","volume":"123","author":"Straumann","year":"2000","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2007.11.010_bib44","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1398-9995.2007.01353.x","article-title":"Evaluation of the IgE cross-reactions among vespid venoms: a possible approach for the choice of immunotherapy","volume":"62","author":"Caruso","year":"2007","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907022221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907022221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:11:49Z","timestamp":1758777109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907022221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0091674907022221"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.11.010","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and effectiveness of immunotherapy in patients with indolent systemic mastocytosis presenting with Hymenoptera venom anaphylaxis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}