{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:26:46Z","timestamp":1786991206876,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.jaci.2008.02.004","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T12:07:06Z","timestamp":1207656426000},"page":"893-902.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"title":["Cell-specific activation profile of extracellular signal-regulated kinase 1\/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways"],"prefix":"10.1016","volume":"121","author":[{"given":"Weimin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Balzar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Gorska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafeul","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2008.02.004_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jaci.2006.08.003","article-title":"Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes","volume":"118","author":"Lemiere","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jaci.2004.11.045","article-title":"Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge","volume":"115","author":"Ravensberg","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib3","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1172\/JCI200113557","article-title":"IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells","volume":"108","author":"Laoukili","year":"2001","journal-title":"J Clin Invest"},{"issue":"suppl","key":"10.1016\/j.jaci.2008.02.004_bib4","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jaci.2004.04.039","article-title":"Proliferative aspects of airway smooth muscle","volume":"114","author":"Hirst","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib5","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jaci.2005.06.030","article-title":"Airway smooth muscle: a modulator of airway remodeling in asthma","volume":"116","author":"Lazaar","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jaci.2005.05.042","article-title":"Role of airway smooth muscle in airway remodeling","volume":"116","author":"Joubert","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jaci.2005.07.011","article-title":"Airway remodeling contributes to the progressive loss of lung function in asthma: an overview","volume":"116","author":"Pascual","year":"2005","journal-title":"J Allergy Clinical Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib8","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MMBR.68.2.320-344.2004","article-title":"ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions","volume":"68","author":"Roux","year":"2004","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jaci.2008.02.004_bib9","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1165\/ajrcmb.18.4.2958","article-title":"Hydrogen peroxide activates extracellular signal-regulated kinase via protein kinase C, Raf-1, and MEK1","volume":"18","author":"Abe","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2008.02.004_bib10","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.4049\/jimmunol.164.6.3222","article-title":"p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells","volume":"164","author":"Kujime","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1465-9921-7-12","article-title":"Selective regulation of MAP kinases and chemokine expression after ligation of ICAM-1 on human airway epithelial cells","volume":"7","author":"Krunkosky","year":"2006","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2008.02.004_bib12","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1084\/jem.181.5.1827","article-title":"The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway","volume":"181","author":"Pazdrak","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2008.02.004_bib13","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1182\/blood.V95.6.1911","article-title":"Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases","volume":"95","author":"Kampen","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2008.02.004_bib14","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1164\/ajrccm.153.6.8665053","article-title":"Asthma on Tristan da Cunha: looking for the genetic link","volume":"153","author":"Zemel","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2008.02.004_bib15","first-page":"1974","article-title":"Association of asthma and related diseases with ASTH-I\/J genes on chromosome 11p in Caucasians","volume":"A354","author":"Sreekumar","year":"2000","journal-title":"J Am Soc Hum Genet"},{"key":"10.1016\/j.jaci.2008.02.004_bib16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1165\/rcmb.2002-0011OC","article-title":"Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung","volume":"27","author":"Silverman","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2008.02.004_bib17","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1164\/ajrccm.160.3.9812110","article-title":"Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics","volume":"160","author":"Wenzel","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2008.02.004_bib18","doi-asserted-by":"crossref","first-page":"L1161","DOI":"10.1152\/ajplung.00140.2002","article-title":"Role and regulation of activator protein-1 in toxicant-induced responses of the lung","volume":"283","author":"Reddy","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2008.02.004_bib19","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/emboj\/18.2.420","article-title":"Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2008.02.004_bib20","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/ncb867","article-title":"Sprouty1 and Sprouty2 provide a control mechanism for the Ras\/MAPK signaling pathway","volume":"4","author":"Hanafusa","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2008.02.004_bib21","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1146\/annurev.immunol.22.012703.104716","article-title":"Asthma: mechanisms of disease persistence and progression","volume":"22","author":"Cohn","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib22","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1126\/science.1133715","article-title":"Amphiregulin, a TH2 cytokine enhancing resistance to nematodes","volume":"314","author":"Zaiss","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jaci.2008.02.004_bib23","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1002\/eji.200636112","article-title":"Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells","volume":"36","author":"Yuan","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1165\/rcmb.2006-0180OC","article-title":"IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production","volume":"36","author":"Zhen","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2008.02.004_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI25711","article-title":"ERK1\/2 mitogen-activated protein kinase selectively mediate IL-13-induced lung inflammation and remodeling in vivo","volume":"116","author":"Lee","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2008.02.004_bib26","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.4049\/jimmunol.172.11.7053","article-title":"Anti-inflammatory effects of mitrogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model","volume":"172","author":"Duan","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2008.02.004_bib27","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1093\/emboj\/20.24.7108","article-title":"Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1","volume":"20","author":"Kassel","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2008.02.004_bib28","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1053\/rmed.2000.0814","article-title":"Correlation between objective measures of airway calibre and clinical symptoms in asthma: a systematic review of clinical studies","volume":"94","author":"Stahl","year":"2000","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2008.02.004_bib29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ng2033","article-title":"P38\u03b1 suppresses normal and cancer cell proliferation by antagonizing the JNK\u2013c-Jun pathway","volume":"39","author":"Hui","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2008.02.004_bib30","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/ng2037","article-title":"P38\u03b1 MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation","volume":"39","author":"Ventura","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2008.02.004_bib31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1164\/rccm.200408-1006OC","article-title":"Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice","volume":"171","author":"Duan","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2008.02.004_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.1365-2222.2000.00641.x","article-title":"p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells","volume":"30","author":"Hashimoto","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2008.02.004_bib33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1165\/rcmb.2002-0055OC","article-title":"Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells","volume":"28","author":"Gern","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2008.02.004_bib34","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1084\/jem.20062621","article-title":"MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation","volume":"204","author":"Gorska","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2008.02.004_bib35","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/sj.bjp.0705971","article-title":"Mitogen-activated protein kinase signalling pathways in IL-1 beta-dependent rat airway smooth muscle proliferation","volume":"143","author":"Zhai","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2008.02.004_bib36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1465-9921-7-2","article-title":"TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases","volume":"7","author":"Chen","year":"2006","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2008.02.004_bib37","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/sj.bjp.0705345","article-title":"Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells","volume":"139","author":"Oltmanns","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2008.02.004_bib38","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.4049\/jimmunol.177.6.4064","article-title":"IL-17A induces eotaxin-1\/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1\/2, JNK, and p38) pathways","volume":"177","author":"Rahman","year":"2006","journal-title":"J Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908003503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908003503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T11:53:18Z","timestamp":1677066798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674908003503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0091674908003503"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2008.02.004","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-specific activation profile of extracellular signal-regulated kinase 1\/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2008.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}