{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:05:41Z","timestamp":1793325941239,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.jaci.2008.02.018","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T12:04:58Z","timestamp":1208520298000},"page":"1435-1441.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":306,"title":["T-cell regulation in chronic paranasal sinus disease"],"prefix":"10.1016","volume":"121","author":[{"given":"Nicholas","family":"Van Bruaene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudina Angela","family":"P\u00e9rez-Novo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz M.","family":"Basinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Van Zele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Holtappels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"De Ruyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schmidt-Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezmi","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Van Cauwenberge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gevaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2008.02.018_bib1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"van Zele","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2008.02.018_bib2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1398-9995.2006.01132.x","article-title":"Distinct features of chronic rhinosinusitis with and without nasal polyps","volume":"61","author":"Polzehl","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2008.02.018_bib3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0091-6749(95)70298-9","article-title":"Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis","volume":"96","author":"Hamilos","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2500\/105065800781329573","article-title":"Nasal polyposis: from cytokines to growth","volume":"14","author":"Bachert","year":"2000","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2008.02.018_bib5","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2008.02.018_bib6","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1067\/mai.2000.107045","article-title":"Upregulation of the transcription factor GATA-3 in upper airway mucosa after in vivo and in vitro allergen challenge","volume":"105","author":"Nakamura","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0091-6749(99)70493-8","article-title":"Gene expression of the GATA-3 transcription factor is increased in atopic asthma","volume":"103","author":"Nakamura","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jaci.2005.09.004","article-title":"T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases","volume":"116","author":"Akdis","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib9","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.jaci.2004.07.014","article-title":"Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma","volume":"114","author":"Karagiannidis","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jaci.2005.10.040","article-title":"Absence of T-regulatory cell expression and function in atopic dermatitis skin","volume":"117","author":"Verhagen","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.0105-2896.2006.00413.x","article-title":"The regulation of allergy and asthma","volume":"212","author":"Umetsu","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2008.02.018_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.smim.2003.12.006","article-title":"Antigen-specific regulatory T cells: their induction and role in infection","volume":"16","author":"Mills","year":"2004","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib14","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni1263","article-title":"A function for interleukin 2 in Foxp3-expressing regulatory T cells","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib15","first-page":"43","article-title":"Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection","volume":"293","author":"Coutinho","year":"2005","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib16","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1073\/pnas.0407691102","article-title":"De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+","volume":"102","author":"Walker","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2008.02.018_bib17","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1172\/JCI19441","article-title":"Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+","volume":"112","author":"Walker","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2008.02.018_bib18","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of peripheral CD4+","volume":"198","author":"Chen","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2008.02.018_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1398-9995.2005.00830.x","article-title":"EAACI position paper on rhinosinusitis and nasal polyps executive summary","volume":"60","author":"Fokkens","year":"2005","journal-title":"Allergy"},{"issue":"suppl 6","key":"10.1016\/j.jaci.2008.02.018_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaci.2004.09.029","article-title":"Rhinosinusitis: establishing definitions for clinical research and patient care","volume":"114","author":"Meltzer","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib21","article-title":"Impact of RNA quality on reference gene expression stability","volume":"39","author":"Perez-Novo","year":"2005","journal-title":"Biotechniques"},{"key":"10.1016\/j.jaci.2008.02.018_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2008.02.018_bib23","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jaci.2008.02.018_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2008.02.018_bib25","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jaci.2007.08.044","article-title":"Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells","volume":"120","author":"Torgerson","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib26","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/MLG.0b013e318033f99a","article-title":"A possible role of CD4+CD25+ T cells as well as transcription factor Foxp3 in the dysregulation of allergic rhinitis","volume":"117","author":"Xu","year":"2007","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2008.02.018_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.cr.7310002","article-title":"GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors","volume":"16","author":"Zhu","year":"2006","journal-title":"Cell Res"},{"key":"10.1016\/j.jaci.2008.02.018_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.febslet.2004.06.026","article-title":"GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements","volume":"570","author":"Kaminuma","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2008.02.018_bib29","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/clim.1999.4718","article-title":"GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels","volume":"91","author":"Ferber","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0091-6749(97)80019-X","article-title":"IL-5 synthesis is upregulated in human nasal polyp tissue","volume":"99","author":"Bachert","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib31","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.158.8.3902","article-title":"Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia","volume":"158","author":"Simon","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib32","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1172\/JCI119311","article-title":"Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells","volume":"99","author":"Pawankar","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2008.02.018_bib33","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/ni1486","article-title":"Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3","volume":"8","author":"Taghon","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/14728222.11.6.737","article-title":"Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity","volume":"11","author":"Huang","year":"2007","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jaci.2008.02.018_bib35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jaci.2007.06.039","article-title":"TH17 cells in the big picture of immunology","volume":"120","author":"Schmidt-Weber","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib36","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/intimm\/dxh126","article-title":"TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo","volume":"16","author":"Schramm","year":"2004","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2008.02.018_bib37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1359-6101(99)00010-6","article-title":"Latent transforming growth factor-beta binding proteins (LTBPs): structural extracellular matrix proteins for targeting TGF-beta action","volume":"10","author":"Saharinen","year":"1999","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jaci.2008.02.018_bib38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/00005537-200301000-00022","article-title":"The pathogenesis of nasal polyposis by immunoglobulin E and interleukin-5 is completed by transforming growth factor-beta1","volume":"113","author":"Hirschberg","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2008.02.018_bib39","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2500\/ajr.2007.21.2968","article-title":"Microarray cDNA to identify inflammatory genes in nasal polyposis","volume":"21","author":"Figueiredo","year":"2007","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2008.02.018_bib40","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1378\/chest.06-2434","article-title":"Regulatory T cells in allergy and asthma","volume":"132","author":"Larche","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2008.02.018_bib41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1084\/jem.184.1.19","article-title":"Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells","volume":"184","author":"Groux","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2008.02.018_bib42","doi-asserted-by":"crossref","first-page":"900","DOI":"10.4049\/jimmunol.168.2.900","article-title":"The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis","volume":"168","author":"Fuss","year":"2002","journal-title":"J Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908003734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908003734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:11:39Z","timestamp":1758787899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674908003734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0091674908003734"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2008.02.018","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T-cell regulation in chronic paranasal sinus disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2008.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}