{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:40:17Z","timestamp":1772930417431,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.jaci.2008.08.009","type":"journal-article","created":{"date-parts":[[2008,9,21]],"date-time":"2008-09-21T09:21:35Z","timestamp":1221988895000},"page":"929-935.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults"],"prefix":"10.1016","volume":"122","author":[{"given":"Jennifer S.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengxiu","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A.","family":"Pongracic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houxun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2008.08.009_bib1","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/j.1398-9995.2005.00877.x","article-title":"Prevalence of asthma, allergic rhinoconjunctivitis and allergic sensitization in Mongolia","volume":"60","author":"Viinanen","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib2","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1046\/j.1365-2222.2001.01240.x","article-title":"Crete: does farming explain urban and rural differences in atopy?","volume":"31","author":"Barnes","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/thx.52.2.161","article-title":"Exercise induced bronchospasm in Ghana: difference in prevalence between urban and rural schoolchildren","volume":"52","author":"Addo Yobo","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2008.08.009_bib4","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1164\/ajrccm.161.5.9908119","article-title":"Relative scarcity of asthma and atopy among rural adolescents raised on a farm","volume":"161","author":"Ernst","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2008.08.009_bib5","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1046\/j.1365-2222.2001.01070.x","article-title":"Having lived on a farm and protection against allergic diseases in Australia","volume":"31","author":"Downs","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2222.2003.01566.x","article-title":"Which factors explain the lower prevalence of atopy amongst farmers' children?","volume":"33","author":"Remes","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib7","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(97)07302-9","article-title":"Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC","volume":"351","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2008.08.009_bib8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1183\/09031936.97.10020354","article-title":"Prevalence of asthma and allergy in Hong Kong schoolchildren: an ISAAC study","volume":"10","author":"Leung","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2008.08.009_bib9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1183\/09031936.02.002319.02","article-title":"Individual allergens as risk factors for asthma and bronchial hyperresponsiveness in Chinese children","volume":"19","author":"Wong","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2008.08.009_bib10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1081\/JAS-120002289","article-title":"Inhalant Allergens as Risk Factors for the Development and Severity of Mild to Moderate Asthma in Hong Kong Chinese Children","volume":"39","author":"Leung","year":"2002","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2008.08.009_bib11","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1542\/peds.2006-2114","article-title":"Patterns and interrelationships of body fat measures among rural Chinese children aged 6-18 years","volume":"120","author":"Wang","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2008.08.009_bib12","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1093\/sleep\/30.12.1688","article-title":"Short sleep duration and adiposity in Chinese adolescents","volume":"30","author":"Yu","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.jaci.2008.08.009_bib13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ypmed.2007.07.014","article-title":"Monozygotic co-twin analyses of body composition measurements and serum lipids","volume":"45","author":"Necheles","year":"2007","journal-title":"Prev Med"},{"key":"10.1016\/j.jaci.2008.08.009_bib14","first-page":"467","article-title":"Hypervariable \u201cminisatellite\u201d regions in human DNA","volume":"24","author":"Jeffreys","year":"1985","journal-title":"Biotechnology"},{"key":"10.1016\/j.jaci.2008.08.009_bib15","series-title":"Handbook of human immunology","first-page":"63","article-title":"Human Immunoglobulins","author":"Hamilton","year":"2008"},{"key":"10.1016\/j.jaci.2008.08.009_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0091-6749(80)90026-3","article-title":"Age-related immunoglobulin E levels in healthy subjects and in patients with allergic disease","volume":"66","author":"Wittig","year":"1980","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.08.009_bib17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1183\/09031936.06.00021305","article-title":"The effects of farming and birth order on asthma and allergies","volume":"28","author":"Zekveld","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2008.08.009_bib18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJM200008243430803","article-title":"Siblings, day-care attendance, and the risk of asthma and wheezing during childhood","volume":"343","author":"Ball","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2008.08.009_bib19","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1046\/j.1365-2222.1998.0280121454.x","article-title":"The influence of birth order on the expression of atopy in families: a gene-environment interaction?","volume":"28","author":"Von Mutius","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2222.1997.tb00701.x","article-title":"The association of family size with atopy and atopic disease","volume":"27","author":"Jarvis","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1513\/pats.200701-028AW","article-title":"Asthma and allergies in rural areas of Europe","volume":"4","author":"von Mutius","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaci.2008.08.009_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3121\/cmr.2.1.5","article-title":"Asthma and atopy in rural children: Is farming protective?","volume":"2","author":"Naleway","year":"2004","journal-title":"Clin Med Res"},{"key":"10.1016\/j.jaci.2008.08.009_bib23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1398-9995.2005.00939.x","article-title":"Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle\u2014the PARSIFAL study","volume":"61","author":"Alfven","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib24","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1365-2222.1998.00281.x","article-title":"Indoor environment of residential homes in Hong Kong\u2014relevance to asthma and allergic disease","volume":"28","author":"Leung","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0091-6749(94)90080-9","article-title":"Seasonal variation of house dust mite allergen (Der p 1) in a subtropical climate","volume":"94","author":"Li","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.08.009_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000102619","article-title":"Detection of Dermatophagoides farinae in the dust of air conditioning filters","volume":"144","author":"Liu","year":"2007","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2008.08.009_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1382-6689(97)10049-7","article-title":"The frequency of food allergy in Australia and Asia","volume":"4","author":"Hill","year":"1997","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.jaci.2008.08.009_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1081\/JAS-120004922","article-title":"Sensitization to common food allergens is a risk factor for asthma in young Chinese children in Hong Kong","volume":"39","author":"Leung","year":"2002","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2008.08.009_bib29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jemermed.2004.11.028","article-title":"Anaphylaxis presentations to an emergency department in Hong Kong: incidence and predictors of biphasic reactions","volume":"4","author":"Smit","year":"2005","journal-title":"J Emerg Med"},{"key":"10.1016\/j.jaci.2008.08.009_bib30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1067\/mai.2001.119408","article-title":"Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins","volume":"108","author":"Strachan","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.08.009_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1164\/rccm.200607-994OC","article-title":"Atopic sensitization and the international variation of asthma symptom prevalence in children","volume":"176","author":"Weinmayr","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2008.08.009_bib32","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jaci.2005.12.1352","article-title":"Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life","volume":"117","author":"Venter","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.08.009_bib33","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.79.5.683","article-title":"Prospective appraisal of complaints of adverse reactions to foods in children during the first 3 years of life","volume":"79","author":"Bock","year":"1987","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2008.08.009_bib34","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1365-2222.2005.2324.x","article-title":"The predictive value of the skin prick test weal size for the outcome of oral food challenges","volume":"35","author":"Verstege","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2008.08.009_bib35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1399-3038.2004.00188.x","article-title":"The diagnostic value of skin prick testing in children with food allergy","volume":"15","author":"Hill","year":"2004","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2008.08.009_bib36","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/0091-6749(93)90019-C","article-title":"Comparison performance of five commercial prick skin test devices","volume":"92","author":"Nelson","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.08.009_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0091-6749(98)70409-9","article-title":"Evaluation of devices for skin prick testing","volume":"101","author":"Nelson","year":"1998","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908015017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908015017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:12:42Z","timestamp":1758787962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674908015017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0091674908015017"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2008.08.009","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2008.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}