{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:36:36Z","timestamp":1758818196088,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.jaci.2008.08.016","type":"journal-article","created":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T04:31:05Z","timestamp":1221885065000},"page":"908-913.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Immunosuppression of TH2 responses in Trichinella spiralis infection by Helicobacter pylori neutrophil-activating protein"],"prefix":"10.1016","volume":"122","author":[{"given":"Gianfranco","family":"Del Prete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Chiumiento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amedeo","family":"Amedei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario M.","family":"D'Elios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Codolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"de Bernard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Masetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Bruschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2008.08.016_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1172\/JCI115300","article-title":"Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production","volume":"88","author":"Del Prete","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2008.08.016_bib3","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.4049\/jimmunol.154.9.4675","article-title":"IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice","volume":"154","author":"Urban","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","article-title":"Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites","volume":"201","author":"Finkelman","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2008.08.016_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-3024.2006.00920.x","article-title":"The role of IL-4, IL-13 and IL-4Ra in the development of protective and pathological responses to Trichinella spiralis","volume":"29","author":"Scales","year":"2007","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib6","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/eji.1830230707","article-title":"Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders","volume":"23","author":"Del Prete","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.179.1.347","article-title":"Cytokine-mediated regulation of chronic intestinal helminth infection","volume":"179","author":"Else","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2008.08.016_bib8","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Grunig","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jaci.2008.08.016_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1074-7613(00)80477-X","article-title":"IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis","volume":"8","author":"Urban","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2008.08.016_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1084\/jem.188.2.399","article-title":"Interleukin (IL)-4-independent induction of immunoglobulin (Ig) E, and perturbation of T cell development in transgenic mice expressing IL-13","volume":"188","author":"Emson","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2008.08.016_bib11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4049\/jimmunol.174.2.1063","article-title":"Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production","volume":"174","author":"Gessner","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib12","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1128\/iai.63.6.2213-2220.1995","article-title":"Characterization of a Helicobacter pylori neutrophil-activating protein","volume":"63","author":"Evans","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2008.08.016_bib13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1286-4579(03)00124-2","article-title":"Molecular and cellular mechanisms of action of the vacuolating cytotoxin (VacA) and neutrophil-activating protein (HP-NAP) virulence factors of Helicobacter pylori","volume":"5","author":"Montecucco","year":"2003","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jaci.2008.08.016_bib14","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1172\/JCI27177","article-title":"The neutrophil activating protein of Helicobacter pylori promotes T helper type 1 immune responses","volume":"116","author":"Amedei","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2008.08.016_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4894(92)90116-R","article-title":"Trichinella spiralis: modifications of the cuticle of the newborn larva during passage through the lung","volume":"75","author":"Bruschi","year":"1992","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.jaci.2008.08.016_bib16","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s004360100467","article-title":"The measurement of parasite antigen-specific IgE levels using anti-IgE monoclonal antibodies and biotinylated antigens","volume":"87","author":"Takamoto","year":"2001","journal-title":"Parasitol Res"},{"key":"10.1016\/j.jaci.2008.08.016_bib17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jaci.2004.03.024","article-title":"Mechanisms of immunotherapy","volume":"113","author":"Till","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib18","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1172\/JCI200316142","article-title":"Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts","volume":"111","author":"Turcanu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2008.08.016_bib19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000024144","article-title":"IP-10 mediated reinforcement of human type 1 cytokine synthesis to environmental allergens among non-atopic subjects","volume":"118","author":"Gangu","year":"1999","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1067\/mai.2000.107927","article-title":"Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity","volume":"106","author":"Tighe","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib21","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.vaccine.2004.11.010","article-title":"Mucosal adjuvants","volume":"23","author":"Freytag","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2008.08.016_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.iy.13.040195.001343","article-title":"Interleukin-12: a proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity","volume":"13","author":"Trinchieri","year":"1995","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib23","first-page":"409","article-title":"Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies","volume":"3","author":"Atkins","year":"1997","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jaci.2008.08.016_bib24","first-page":"2541","article-title":"Effects of single-dose interleukin-12 exposure on interleukin-12- associated toxicity and interferon-\u03b3 production","volume":"90","author":"Leonard","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2008.08.016_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1359-6101(01)00032-6","article-title":"Interleukin-12 in anti-tumor immunity and immunotherapy","volume":"13","author":"Colombo","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jaci.2008.08.016_bib26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nsb0498-294","article-title":"The crystal structure of Dps, a ferritin homolog that binds and protects DNA","volume":"5","author":"Grant","year":"1998","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.jaci.2008.08.016_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0022-2836(02)00879-3","article-title":"Structure of the neutrophil-activating protein from Helicobacter pylori","volume":"323","author":"Zanotti","year":"2002","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jaci.2008.08.016_bib28","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","article-title":"Novel p19 engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12","volume":"13","author":"Oppmann","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2008.08.016_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib30","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4049\/jimmunol.158.2.962","article-title":"T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease","volume":"158","author":"D'Elios","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0020-7519(96)89377-5","article-title":"Trichinella isolates: parasite variability and host responses","volume":"26","author":"Wakelin","year":"1996","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.jaci.2008.08.016_bib32","series-title":"Guidelines for the surveillance, management, prevention and control of trichinellosis","first-page":"37","article-title":"Management and diagnosis of clinical trichinellosis","author":"Dupouy-Camet","year":"2007"},{"key":"10.1016\/j.jaci.2008.08.016_bib33","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.4049\/jimmunol.140.12.4193","article-title":"IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants","volume":"140","author":"Del Prete","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2008.08.016_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1067\/mai.2000.104575","article-title":"The role of lymphocytes in allergic disease","volume":"105","author":"Romagnani","year":"2000","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908015121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908015121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:12:25Z","timestamp":1758787945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674908015121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0091674908015121"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2008.08.016","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunosuppression of TH2 responses in Trichinella spiralis infection by Helicobacter pylori neutrophil-activating protein","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2008.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}