{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:45:15Z","timestamp":1792604715503,"version":"4.5.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.jaci.2008.12.008","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T05:49:23Z","timestamp":1233985763000},"page":"672-679","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":166,"title":["High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: A randomized, placebo-controlled, crossover study"],"prefix":"10.1016","volume":"123","author":[{"given":"Frank","family":"Siebenhaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Degener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Zuberbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Martus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2008.12.008_bib1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2230.2007.02376.x","article-title":"Acquired cold urticaria: clinical picture and update on diagnosis and treatment","volume":"32","author":"Siebenhaar","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaci.2008.12.008_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.iac.2004.01.001","article-title":"The spectrum of acquired and familial cold-induced urticaria\/urticaria-like syndromes","volume":"24","author":"Wanderer","year":"2004","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaci.2008.12.008_bib3","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1182\/blood-2003-07-2531","article-title":"Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA\/NOMID, MWS, and FCU","volume":"103","author":"Neven","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2008.12.008_bib4","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jaci.2004.07.018","article-title":"Peltier effect-based temperature challenge: an improved method for diagnosing cold urticaria","volume":"114","author":"Siebenhaar","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.12.008_bib5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jaci.2006.04.003","article-title":"Successful treatment of cold-induced urticaria\/anaphylaxis with anti-IgE","volume":"117","author":"Boyce","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2008.12.008_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1398-9995.2005.00962.x","article-title":"EAACI\/GA2LEN\/EDF guideline: management of urticaria","volume":"61","author":"Zuberbier","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2008.12.008_bib7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1398-9995.2005.00964.x","article-title":"EAACI\/GA2LEN\/EDF guideline: definition, classification and diagnosis of urticaria","volume":"61","author":"Zuberbier","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2008.12.008_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1398-9995.2004.00641.x","article-title":"Desloratadine prevents compound 48\/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique","volume":"60","author":"Wang","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2008.12.008_bib9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1600-0625.1995.tb00257.x","article-title":"Pharmacological modulation of IL-6 and IL-8 secretion by the H1-antagonist decarboethoxy-loratadine and dexamethasone by human mast and basophilic cell lines","volume":"4","author":"Lippert","year":"1995","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2008.12.008_bib10","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s00011-004-1309-6","article-title":"Inhibitory effects of budesonide, desloratadine and dexamethasone on cytokine release from human mast cell line (HMC-1)","volume":"53","author":"Zhao","year":"2004","journal-title":"Inflamm Res"},{"issue":"suppl 65","key":"10.1016\/j.jaci.2008.12.008_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1034\/j.1398-9995.2001.00101.x","article-title":"The pharmacologic profile of desloratadine: a review","volume":"56","author":"Henz","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2008.12.008_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2165\/00128071-200708010-00005","article-title":"Efficacy and safety of desloratadine in adults with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, multicenter trial","volume":"8","author":"Ortonne","year":"2007","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jaci.2008.12.008_bib13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1067\/mjd.2003.143","article-title":"Efficacy and safety of desloratadine 5 mg once daily in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial","volume":"48","author":"Monroe","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2008.12.008_bib14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1046\/j.1365-4362.2001.00186.x","article-title":"Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study","volume":"40","author":"Ring","year":"2001","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaci.2008.12.008_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1468-3083.2007.02385.x","article-title":"Quality of life in adults with chronic idiopathic urticaria receiving desloratadine: a randomized, double-blind, multicentre, placebo-controlled study","volume":"22","author":"Grob","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2008.12.008_bib16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/09546630310018077","article-title":"Inhibition of cold urticaria by desloratadine","volume":"15","author":"Juhlin","year":"2004","journal-title":"J Dermatolog Treat"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908023725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674908023725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:14:21Z","timestamp":1758788061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674908023725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0091674908023725"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2008.12.008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1148889.605976","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: A randomized, placebo-controlled, crossover study","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2008.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}