{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:25:30Z","timestamp":1783113930374,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.jaci.2009.03.038","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T04:36:41Z","timestamp":1243485401000},"page":"129-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":170,"title":["Hereditary angioedema caused by missense mutations in the factor XII gene: Clinical features, trigger factors, and therapy"],"prefix":"10.1016","volume":"124","author":[{"given":"Konrad","family":"Bork","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Wulff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Hardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Witzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Staubach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2009.03.038_bib1","first-page":"129","article-title":"\u00dcber akutes umschriebenes Haut\u00f6dem","volume":"1","author":"Quincke","year":"1882","journal-title":"Monatsh Prakt Dermatol"},{"key":"10.1016\/j.jaci.2009.03.038_bib2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00000441-188804000-00004","article-title":"Hereditary angioneurotic edema","volume":"95","author":"Osler","year":"1888","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jaci.2009.03.038_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9343(63)90162-1","article-title":"A biochemical abnormality in hereditary angioneurotic edema: absence of serum inhibitor of C1-esterase","volume":"35","author":"Donaldson","year":"1963","journal-title":"Am J Med"},{"key":"10.1016\/j.jaci.2009.03.038_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(00)02483-1","article-title":"Hereditary angioedema with normal C1-inhibitor activity in women","volume":"356","author":"Bork","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2009.03.038_bib5","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1067\/mai.2001.114242","article-title":"Hereditary angioedema type III: an additional French pedigree with autosomal dominant transmission","volume":"107","author":"Martin","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.03.038_bib6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0002-9343(02)01526-7","article-title":"Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by oral contraceptives or hormone replacement therapy","volume":"114","author":"Bork","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.jaci.2009.03.038_bib7","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1067\/mai.2000.108106","article-title":"Clinical, biochemical, and genetic characterization of a novel estrogen-dependent inherited form of angioedema","volume":"106","author":"Binkley","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.03.038_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-2133.2004.05669.x","article-title":"Efficacy of danazol treatment in a patient with the new variant of hereditary angio-oedema (HAE III)","volume":"150","author":"Herrmann","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2009.03.038_bib9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1365-2133.2007.07778.x","article-title":"A case of hereditary angio-oedema type III presenting with C1-inhibitor cleavage and a missense mutation in the F12 gene","volume":"156","author":"Bouillet","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2009.03.038_bib10","first-page":"253","article-title":"Analgesia obstetrica en un caso de edema angioneurotico hereditario tipo III","volume":"54","author":"Fiz Matias","year":"2007","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"10.1016\/j.jaci.2009.03.038_bib11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1398-9995.2007.01579.x","article-title":"Oestrogen-dependent hereditary angio-oedema with normal C1 inhibitor: description of six new cases and review of pathogenic mechanisms and treatment","volume":"63","author":"Serrano","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2009.03.038_bib12","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1365-2133.2005.07048.x","article-title":"Hereditary angio-oedema with normal C1 inhibitor in a family with affected women and men","volume":"154","author":"Bork","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2009.03.038_bib13","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.amjmed.2007.08.021","article-title":"Hereditary angioedema with normal C1 inhibitor: clinical symptoms and course","volume":"120","author":"Bork","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.jaci.2009.03.038_bib14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jaci.2007.07.002","article-title":"Hereditary angioedema with normal C1 inhibitor gene in a family with affected women and men is associated with the p.Thr328Lys mutation in the F12 gene","volume":"120","author":"Martin","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.03.038_bib15","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.bbrc.2006.03.092","article-title":"Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor","volume":"343","author":"Dewald","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2009.03.038_bib16","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1086\/509899","article-title":"Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III","volume":"79","author":"Cichon","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2009.03.038_bib17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/00313020701716433","article-title":"First molecular confirmation of an Australian case of type III hereditary angioedema","volume":"40","author":"Bell","year":"2008","journal-title":"Pathology"},{"key":"10.1016\/j.jaci.2009.03.038_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.amjmed.2005.09.064","article-title":"Hereditary angioedema: new findings concerning symptoms, affected organs, and course","volume":"119","author":"Bork","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.jaci.2009.03.038_bib19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00005792-199207000-00003","article-title":"Hereditary and acquired C1-inhibitor deficiency: biological and clinical characteristics in 235 patients","volume":"71","author":"Agostoni","year":"1992","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaci.2009.03.038_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1067\/mai.2001.114243","article-title":"Reply (Hereditary angioedema type III: an additional French pedigree with autosomal dominant transmission)","volume":"107","author":"Binkley","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.03.038_bib21","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1172\/JCI200214211","article-title":"Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor","volume":"109","author":"Han","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.03.038_bib22","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.jaci.2007.02.012","article-title":"Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant)","volume":"119","author":"Bork","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.03.038_bib23","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S1081-1206(10)60580-7","article-title":"Hereditary angioedema: a current state-of-the-art review, III: mechanisms of hereditary angioedema","volume":"100","author":"Davis","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2009.03.038_bib24","doi-asserted-by":"crossref","unstructured":"Bork K, Kleist R, Hardt J, Witzke G. Kallikrein\u2013kinin system and fibrinolysis in hereditary angioedema due to the factor XII gene mutation Thr309Lys. Blood Coagul Fibrinolysis. In press 2009.","DOI":"10.1097\/MBC.0b013e32832811f8"},{"key":"10.1016\/j.jaci.2009.03.038_bib25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1398-9995.2008.01859.x","article-title":"Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiency","volume":"64","author":"Cugno","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2009.03.038_bib26","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jaci.2008.01.071","article-title":"Potential role of vasomotor effects of fibrinogen in bradykinin-induced angioedema","volume":"121","author":"Bas","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.03.038_bib27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1365-2133.2004.06152.x","article-title":"Hereditary angio-oedema: effective treatment with the progestogen-only pill in a young woman","volume":"151","author":"Amar","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2009.03.038_bib28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1081-1206(10)60424-3","article-title":"Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients","volume":"100","author":"Bork","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2009.03.038_bib29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jaci.2007.10.048","article-title":"Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P","volume":"121","author":"Drouet","year":"2008","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167490900548X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167490900548X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:14:34Z","timestamp":1758788074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167490900548X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S009167490900548X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.03.038","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1167988.630093","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hereditary angioedema caused by missense mutations in the factor XII gene: Clinical features, trigger factors, and therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.03.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}