{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:43:25Z","timestamp":1788248605420,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.jaci.2009.04.014","type":"journal-article","created":{"date-parts":[[2009,5,31]],"date-time":"2009-05-31T04:26:33Z","timestamp":1243743993000},"page":"52-58.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection"],"prefix":"10.1016","volume":"124","author":[{"given":"Hanna","family":"Juntti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"\u00d6sterlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Kokkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teija","family":"Dunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo","family":"Renko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tytti","family":"Pokka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Julkunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Uhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2009.04.014_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2009.04.014_bib2","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1136\/bmj.284.6330.1665","article-title":"Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy","volume":"284","author":"Pullan","year":"1982","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2009.04.014_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2009.04.014_bib4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/INF.0b013e3180618c42","article-title":"The association between respiratory syncytial virus infection and the development of childhood asthma: a systematic review of the literature","volume":"26","author":"Perez-Yarza","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2009.04.014_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1086\/376530","article-title":"Differences in participation of innate and adaptive immunity to respiratory syncytial virus in adults and neonates","volume":"188","author":"Krishnan","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2009.04.014_bib6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2249.2004.02582.x","article-title":"Severe respiratory syncytial virus infections and reduced interferon-gamma generation in vitro","volume":"138","author":"Schauer","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2009.04.014_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2222.2004.02125.x","article-title":"Serum concentrations of interferon-gamma and intercellular adhesion molecule-1 eight years after an early respiratory syncytial virus infection","volume":"35","author":"Juntti","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2009.04.014_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1399-3038.2006.00499.x","article-title":"Consumption of asthma medication after RS-virus epidemic\u2014a population based survey","volume":"18","author":"Dunder","year":"2007","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.04.014_bib9","unstructured":"Juntti H, \u00d6sterlund P, Kokkonen J, Dunder T, Renko M, Pokka T, et al. Cytokine responses in cord blood leukocytes predict the severity of later respiratory syncytial virus infection. Abstract presented at: the 26th Annual Meeting of the European Society for Paediatric Infectious Diseases; 2008; Graz, Austria."},{"key":"10.1016\/j.jaci.2009.04.014_bib10","unstructured":"Respiratory syncytial virus (RSV) by province. Public Health Institute of Finland. Available at: http:\/\/www3.ktl.fi\/stat\/. Accessed February 3, 2009."},{"key":"10.1016\/j.jaci.2009.04.014_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3109\/00365548809035659","article-title":"Antigen detection in the diagnosis of viral infections","volume":"20","author":"Hietala","year":"1988","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.jaci.2009.04.014_bib12","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1099\/0022-1317-70-12-3261","article-title":"Polymerase chain reaction for human picornaviruses","volume":"70","author":"Hyypi\u00e4","year":"1989","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jaci.2009.04.014_bib13","series-title":"An easy guide to factor analysis","author":"Kline","year":"1994"},{"key":"10.1016\/j.jaci.2009.04.014_bib14","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1034\/j.1398-9995.2003.00233.x","article-title":"Association of an early respiratory syncytial virus infection and atopic allergy","volume":"58","author":"Juntti","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2009.04.014_bib15","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1164\/rccm.200804-579OC","article-title":"Evidence of a causal role of winter virus infection during infancy in early childhood asthma","volume":"178","author":"Wu","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2009.04.014_bib16","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2006.12.669","article-title":"Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma","volume":"119","author":"Kusel","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.04.014_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2005.10.002","article-title":"Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life","volume":"117","author":"Gern","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.04.014_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1099-0496(199909)28:3<175::AID-PPUL3>3.0.CO;2-U","article-title":"Decreased interleukin-12 levels in umbilical cord blood in children who developed acute bronchiolitis","volume":"28","author":"Blanco-Quiros","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2009.04.014_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1203\/01.pdr.0000228319.10481.ea","article-title":"Innate immunity of the human newborn is polarized toward a high ratio of IL-6\/TNF-alpha production in vitro and in vivo","volume":"60","author":"Angelone","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jaci.2009.04.014_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1046\/j.1365-2249.2002.01817.x","article-title":"Neonatal dendritic cells are intrinsically biased against Th-1 immune responses","volume":"128","author":"Langrish","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2009.04.014_bib21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1365-2249.1996.d01-874.x","article-title":"Respiratory syncytial virus-induced cytokine production by neonatal macrophages","volume":"106","author":"Tsutsumi","year":"1996","journal-title":"Clin Exp Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2009.04.014_bib22","doi-asserted-by":"crossref","first-page":"S460","DOI":"10.1067\/mai.2003.108","article-title":"2. Cytokines and chemokines","volume":"111","author":"Borish","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.04.014_bib23","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.4049\/jimmunol.175.6.3463","article-title":"Directing transition from innate to acquired immunity: defining a role for IL-6","volume":"175","author":"Jones","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.04.014_bib24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/jlb.56.5.559","article-title":"Essential involvement of interleukin-8 (IL-8) in acute inflammation","volume":"56","author":"Harada","year":"1994","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2009.04.014_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00006454-199902000-00007","article-title":"Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease","volume":"18","author":"Sheeran","year":"1999","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2009.04.014_bib26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ppul.10080","article-title":"Respiratory syncytial virus bronchiolitis: disease severity, interleukin-8, and virus genotype","volume":"33","author":"Smyth","year":"2002","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2009.04.014_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1183\/09031936.03.00048103","article-title":"Pro- and anti-inflammatory responses in respiratory syncytial virus bronchiolitis","volume":"23","author":"McNamara","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2009.04.014_bib28","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1086\/383350","article-title":"Differential production of inflammatory cytokines in primary infection with human metapneumovirus and with other common respiratory viruses of infancy","volume":"189","author":"Laham","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2009.04.014_bib29","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1086\/515575","article-title":"Immunopathogenesis of respiratory syncytial virus bronchiolitis","volume":"195","author":"Bennett","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2009.04.014_bib30","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1086\/520886","article-title":"Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes","volume":"196","author":"Janssen","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2009.04.014_bib31","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/00006454-199510000-00027","article-title":"Elevated plasma interleukin 8 in respiratory syncytial virus bronchiolitis","volume":"14","author":"Biswas","year":"1995","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2009.04.014_bib32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1034\/j.1399-3003.1999.14a24.x","article-title":"Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis","volume":"14","author":"Bont","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2009.04.014_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/1096-9071(200010)62:2<267::AID-JMV20>3.0.CO;2-8","article-title":"Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity","volume":"62","author":"Brandenburg","year":"2000","journal-title":"J Med Virol"},{"key":"10.1016\/j.jaci.2009.04.014_bib34","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1136\/thorax.55.12.1023","article-title":"Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families","volume":"55","author":"Hull","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2009.04.014_bib35","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1365-2222.2004.1947.x","article-title":"Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis","volume":"34","author":"Goetghebuer","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2009.04.014_bib36","doi-asserted-by":"crossref","first-page":"24s","DOI":"10.1183\/09031936.01.00229601","article-title":"Cytokines in asthma","volume":"34","author":"Kips","year":"2001","journal-title":"Eur Respir J Suppl"},{"key":"10.1016\/j.jaci.2009.04.014_bib37","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1128\/CMR.18.3.541-555.2005","article-title":"Immune responses and disease enhancement during respiratory syncytial virus infection","volume":"18","author":"Openshaw","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jaci.2009.04.014_bib38","doi-asserted-by":"crossref","first-page":"L222","DOI":"10.1152\/ajplung.00148.2005","article-title":"Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model","volume":"290","author":"Phaybouth","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2009.04.014_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.200312-1647OC","article-title":"Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life","volume":"170","author":"Copenhaver","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"suppl","key":"10.1016\/j.jaci.2009.04.014_bib40","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1067\/S0022-3476(03)00511-0","article-title":"Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease","volume":"143","author":"Simoes","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2009.04.014_bib41","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1542\/peds.2004-0059","article-title":"Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy","volume":"115","author":"Bradley","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2009.04.014_bib42","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0140-6736(03)14542-4","article-title":"Association between antenatal cytokine production and the development of atopy and asthma at age 6 years","volume":"362","author":"Macaubas","year":"2003","journal-title":"Lancet"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909006393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909006393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:15:19Z","timestamp":1758788119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674909006393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0091674909006393"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.04.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1161042.621504","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}