{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:10:17Z","timestamp":1790917817659,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.jaci.2009.04.029","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T05:19:47Z","timestamp":1247203187000},"page":"809-818.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Prostaglandin E2\u2013EP3 signaling suppresses skin inflammation in murine contact hypersensitivity"],"prefix":"10.1016","volume":"124","author":[{"given":"Tetsuya","family":"Honda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Miyachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuh","family":"Narumiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2009.04.029_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-5699(97)01186-9","article-title":"Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity","volume":"19","author":"Grabbe","year":"1998","journal-title":"Immunol Today"},{"key":"10.1016\/j.jaci.2009.04.029_bib2","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1189\/jlb.0304193","article-title":"The intensity of neutrophil infiltration controls the number of antigen-primed CD8 T cells recruited into cutaneous antigen challenge sites","volume":"76","author":"Engeman","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2009.04.029_bib3","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3485::AID-IMMU3485>3.0.CO;2-B","article-title":"Groalpha-mediated recruitment of neutrophils is required for elicitation of contact hypersensitivity","volume":"29","author":"Dilulio","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nm0202-157","article-title":"CCL27-CCR10 interactions regulate T cell-mediated skin inflammation","volume":"8","author":"Homey","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2009.04.029_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0165-2478(03)00017-8","article-title":"Kinetic profiles of sequential gene expressions for chemokines in mice with contact hypersensitivity","volume":"86","author":"Mitsui","year":"2003","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaci.2009.04.029_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000233198","article-title":"Arachidonic acid metabolism in skin: experimental contact dermatitis in guinea pigs","volume":"69","author":"Ruzicka","year":"1982","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/abio.2000.4540","article-title":"Quantitation of arachidonic acid metabolites in small tissue biopsies by reversed-phase high-performance liquid chromatography","volume":"280","author":"Eberhard","year":"2000","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jaci.2009.04.029_bib8","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1999.79.4.1193","article-title":"Prostanoid receptors: structures, properties, and functions","volume":"79","author":"Narumiya","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jaci.2009.04.029_bib9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/intimm\/dxh096","article-title":"CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation","volume":"16","author":"Takeshita","year":"2004","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib10","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1600-0625.2005.00381.x","article-title":"The EP3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes","volume":"14","author":"Konger","year":"2005","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2009.04.029_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/sj.jid.5700502","article-title":"Effects of UVB on E prostanoid receptor expression in murine skin","volume":"127","author":"Tober","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2009.04.029_bib12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni1188","article-title":"Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3","volume":"6","author":"Kunikata","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib13","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/S0022-3565(25)38645-3","article-title":"Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors","volume":"268","author":"Ahluwalia","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jaci.2009.04.029_bib14","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.4049\/jimmunol.173.2.1321","article-title":"E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation","volume":"173","author":"Goulet","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/26233","article-title":"Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3","volume":"395","author":"Ushikubi","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2009.04.029_bib16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nm872","article-title":"Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells","volume":"9","author":"Kabashima","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2009.04.029_bib17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaci.2008.09.044","article-title":"Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis","volume":"123","author":"Ueta","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1084\/jem.20051310","article-title":"Prostacyclin-IP signaling and prostaglandin E2-EP2\/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis","volume":"203","author":"Honda","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.04.029_bib19","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1365-2567.2007.02603.x","article-title":"CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis","volume":"121","author":"Latta","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2009.04.029_bib20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1084\/jem.20041503","article-title":"Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin","volume":"202","author":"Yoo","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.04.029_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model","volume":"11","author":"Sano","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2009.04.029_bib22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature03963","article-title":"Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins","volume":"437","author":"Zenz","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2009.04.029_bib23","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1172\/JCI28034","article-title":"Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy","volume":"117","author":"Tuckermann","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.04.029_bib24","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.4049\/jimmunol.169.8.4586","article-title":"Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production","volume":"169","author":"Nguyen","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib25","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/ni1503","article-title":"Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B","volume":"8","author":"Grimbaldeston","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib26","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1084\/jem.192.10.1441","article-title":"Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2","volume":"192","author":"Biedermann","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.04.029_bib27","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1100\/tsw.2007.182","article-title":"Prostaglandin receptor signaling in disease","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Sci World J"},{"key":"10.1016\/j.jaci.2009.04.029_bib28","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.1142265","article-title":"Attenuation of allergic contact dermatitis through the endocannabinoid system","volume":"316","author":"Karsak","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jaci.2009.04.029_bib29","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jaci.2004.08.041","article-title":"Prostaglandin E(2) suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes","volume":"114","author":"Kanda","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.04.029_bib30","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood-2007-10-115758","article-title":"HIF-1{alpha} regulates epithelial inflammation by cell autonomous NF{kappa}B activation and paracrine stromal remodeling","volume":"111","author":"Scortegagna","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.04.029_bib31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/archderm.1988.01670030053021","article-title":"Action of topically applied arachidonic acid on the skin of patients with psoriasis","volume":"124","author":"Hebborn","year":"1988","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2009.04.029_bib32","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/1523-1747.ep12525265","article-title":"Effects of chronic intracutaneous administration of arachidonic acid and its metabolites. Induction of leukocytoclastic vasculitis by leukotriene B4 and 12-hydroxyeicosatetraenoic acid and its prevention by prostaglandin E2","volume":"88","author":"Ruzicka","year":"1987","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jaci.2009.04.029_bib33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-2230.1989.tb00949.x","article-title":"Psoriasis induced by topically applied indomethacin","volume":"14","author":"Lazarova","year":"1989","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaci.2009.04.029_bib34","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1365-2133.1987.tb07364.x","article-title":"Exacerbation of psoriasis by indomethacin","volume":"117","author":"Powles","year":"1987","journal-title":"Br J Dermatol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167490900685X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167490900685X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:17:30Z","timestamp":1758788250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167490900685X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S009167490900685X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.04.029","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prostaglandin E2\u2013EP3 signaling suppresses skin inflammation in murine contact hypersensitivity","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.04.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}