{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:58:59Z","timestamp":1790179139099,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.jaci.2009.07.034","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T06:53:38Z","timestamp":1252047218000},"page":"507-513.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":215,"title":["Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum"],"prefix":"10.1016","volume":"124","author":[{"given":"Pei-Song","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Rafaels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Hand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanda","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Boguniewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tissa","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon M.","family":"Hanifin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri H.","family":"Beaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen C.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald Y.M.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2009.07.034_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(03)12193-9","article-title":"Atopic dermatitis","volume":"361","author":"Leung","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2009.07.034_bib2","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2009.07.034_bib3","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/jama.296.8.964","article-title":"Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States","volume":"296","author":"Xu","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2009.07.034_bib4","first-page":"137","article-title":"The epidemiology of atopic dermatitis at a tertiary referral skin center in Singapore","volume":"17","author":"Tay","year":"1999","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaci.2006.03.037","article-title":"The genetics of atopic dermatitis","volume":"118","author":"Morar","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jaci.2008.08.002","article-title":"Filaggrin in atopic dermatitis","volume":"122","author":"O'Regan","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaci.2007.04.001","article-title":"Filaggrin null mutations are associated with increased asthma severity in children and young adults","volume":"120","author":"Palmer","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib8","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1038\/sj.jid.5701190","article-title":"Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel","volume":"128","author":"Novak","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2009.07.034_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2340\/00015555-0383","article-title":"Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families","volume":"88","author":"Ekelund","year":"2008","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2009.07.034_bib10","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/j.1398-9995.2008.01660.x","article-title":"Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults","volume":"63","author":"Basu","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2009.07.034_bib11","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jaci.2008.01.026","article-title":"The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study","volume":"121","author":"Henderson","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib12","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jaci.2008.02.014","article-title":"Filaggrin mutations, atopic eczema, hay fever, and asthma in children","volume":"121","author":"Weidinger","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1365-2133.2008.08730.x","article-title":"Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study","volume":"159","author":"de Jongh","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2009.07.034_bib14","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ng2020","article-title":"Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema","volume":"39","author":"Sandilands","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2009.07.034_bib15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaci.2007.04.031","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"120","author":"Howell","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2009.07.034_bib17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/S0190-9622(03)02539-8","article-title":"Consensus conference on pediatric atopic dermatitis","volume":"49","author":"Eichenfield","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2009.07.034_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jaci.2009.05.020","article-title":"Phenotype of subjects with atopic dermatitis with a history of eczema herpeticum","volume":"124","author":"Beck","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1034\/j.1600-0625.2001.100102.x","article-title":"The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group","volume":"10","author":"Hanifin","year":"2001","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2009.07.034_bib20","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jaci.2007.09.037","article-title":"Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma","volume":"120","author":"Rogers","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.immuni.2006.02.006","article-title":"Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus","volume":"24","author":"Howell","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.07.034_bib22","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jaci.2005.12.1345","article-title":"Cathelicidin deficiency predisposes to eczema herpeticum","volume":"117","author":"Howell","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib23","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.jaci.2007.08.067","article-title":"Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data","volume":"120","author":"Baurecht","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib24","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ng.358","article-title":"A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming","volume":"41","author":"Fallon","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2009.07.034_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000109365","article-title":"R501X and 2282del4 filaggrin mutations do not confer susceptibility to psoriasis and atopic dermatitis in Italian patients","volume":"216","author":"Giardina","year":"2008","journal-title":"Dermatology"},{"key":"10.1016\/j.jaci.2009.07.034_bib26","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jaci.2006.12.646","article-title":"Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis","volume":"119","author":"Nomura","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_bib27","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/sj.jid.5701164","article-title":"De novo occurrence of the filaggrin mutation p.R501X with prevalent mutation c.3321delA in a Japanese family with ichthyosis vulgaris complicated by atopic dermatitis","volume":"128","author":"Hamada","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2009.07.034_bib28","doi-asserted-by":"crossref","first-page":"e527","DOI":"10.1542\/peds.2007-0289","article-title":"Atopic dermatitis in children in the United States, 1997-2004: visit trends, patient and provider characteristics, and prescribing patterns","volume":"120","author":"Horii","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2009.07.034_E1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jaci.2009.05.020","article-title":"Phenotype of subjects with atopic dermatitis with a history of eczema herpeticum","volume":"124","author":"Beck","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_E2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1034\/j.1600-0625.2001.100102.x","article-title":"The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group","volume":"10","author":"Hanifin","year":"2001","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2009.07.034_E3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaci.2007.04.031","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"120","author":"Howell","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.034_E4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1086\/381000","article-title":"Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium","volume":"74","author":"Carlson","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2009.07.034_E5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00439-006-0182-5","article-title":"Efficient selection of tagging single-nucleotide polymorphisms in multiple populations","volume":"120","author":"Howie","year":"2006","journal-title":"Hum Genet"},{"key":"10.1016\/j.jaci.2009.07.034_E6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0076-6879(06)10003-8","article-title":"Illumina universal bead arrays","volume":"410","author":"Fan","year":"2006","journal-title":"Methods Enzymol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909011531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909011531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:15:58Z","timestamp":1758788158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674909011531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0091674909011531"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.07.034","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}