{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:48:28Z","timestamp":1761155308273,"version":"3.44.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.jaci.2009.07.039","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T11:52:52Z","timestamp":1254743572000},"page":"1343-1350.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients"],"prefix":"10.1016","volume":"124","author":[{"given":"Franco H.","family":"Falcone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Telford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Hooi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan P.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Seabra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Feary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Venn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Britton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2009.07.039_bib1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.4269\/ajtmh.1972.21.913","article-title":"Raised levels of serum IgE in human helminthiases","volume":"21","author":"Kojima","year":"1972","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jaci.2009.07.039_bib2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/2091221a0","article-title":"Reagin-like antibodies in experimental infections of Schistosoma mansoni and the passive transfer of resistance","volume":"209","author":"Ogilvie","year":"1966","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2009.07.039_bib3","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1182\/blood.V97.10.3303","article-title":"The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase\/phosphodiesterase 3","volume":"97","author":"Buhring","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.07.039_bib4","first-page":"2343","article-title":"The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors","volume":"94","author":"Buhring","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.07.039_bib5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0091-6749(91)90094-5","article-title":"Monitoring human basophil activation via CD63 monoclonal antibody 435","volume":"88","author":"Knol","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/j.1365-2222.2009.03187.x","article-title":"Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study","volume":"39","author":"Feary","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2009.07.039_bib7","doi-asserted-by":"crossref","first-page":"914","DOI":"10.4269\/ajtmh.2006.75.914","article-title":"Dose-ranging study for trials of therapeutic infection with Necator americanus in humans","volume":"75","author":"Mortimer","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"suppl","key":"10.1016\/j.jaci.2009.07.039_bib8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S0031182000065276","article-title":"An initial characterization of the proteolytic enzymes secreted by the adult stage of the human hookworm Necator americanus","volume":"110","author":"Brown","year":"1995","journal-title":"Parasitology"},{"key":"10.1016\/j.jaci.2009.07.039_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1365-3024.1999.00238.x","article-title":"A hookworm allergen which strongly resembles calreticulin","volume":"21","author":"Pritchard","year":"1999","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/sj.cr.7290301","article-title":"Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation","volume":"15","author":"Hennersdorf","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.jaci.2009.07.039_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1067\/mai.2002.125257","article-title":"Recombinant allergens promote expression of CD203c on basophils in sensitized individuals","volume":"110","author":"Hauswirth","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0091-6749(00)90085-X","article-title":"In vitro diagnosis of cypress pollen allergy by using cytofluorimetric analysis of basophils (Basotest)","volume":"105","author":"Paris-Kohler","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-3024.1995.tb00897.x","article-title":"Immunoepidemiology of human necatoriasis: correlations between antibody responses and parasite burdens","volume":"17","author":"Quinnell","year":"1995","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib14","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-2222.2007.02919.x","article-title":"A rapid two-step procedure for the purification of human peripheral blood basophils to near homogeneity","volume":"38","author":"Gibbs","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2009.07.039_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cyto.2005.06.007","article-title":"IL-4 and IL-13 mRNA real-time PCR quantification on whole blood to assess allergic response","volume":"31","author":"Ocmant","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.jaci.2009.07.039_bib16","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2009.07.039_bib17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1471-4922(00)01846-8","article-title":"Do basophils play a role in immunity against parasites?","volume":"17","author":"Falcone","year":"2001","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.jaci.2009.07.039_bib18","first-page":"10","article-title":"Use of CD63 expression as marker of in vitro basophil activation in identifying the culprit in insect venom allergy","volume":"14","author":"Eberlein-Konig","year":"2004","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jim.2006.12.002","article-title":"Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy","volume":"320","author":"Ocmant","year":"2007","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2009.07.039_bib20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1365-2222.2003.01594.x","article-title":"Marked improvement of the basophil activation test by detecting CD203c instead of CD63","volume":"33","author":"Boumiza","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2009.07.039_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000094495","article-title":"Diagnostic tests based on human basophils: potentials, pitfalls and perspectives","volume":"141","author":"Kleine-Tebbe","year":"2006","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000115885","article-title":"Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls","volume":"146","author":"de Weck","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1476-7961-6-12","article-title":"Differential response of human basophil activation markers: a multi-parameter flow cytometry approach","volume":"6","author":"Chirumbolo","year":"2008","journal-title":"Clin Mol Allergy"},{"key":"10.1016\/j.jaci.2009.07.039_bib24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1398-9995.2006.00987.x","article-title":"Basophil allergen threshold sensitivity: a useful approach to anti-IgE treatment efficacy evaluation","volume":"61","author":"Nopp","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2009.07.039_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ymeth.2003.08.006","article-title":"Assays for measuring in vitro basophil activation induced by recombinant allergens","volume":"32","author":"Valent","year":"2004","journal-title":"Methods"},{"key":"10.1016\/j.jaci.2009.07.039_bib26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000237568","article-title":"Characteristics of Fc epsilon RI expression on human monocytes and monocytic cell lines: establishment of an in vitro model","volume":"113","author":"Reischl","year":"1997","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/367183a0","article-title":"High-affinity IgE receptor on eosinophils is involved in defence against parasites","volume":"367","author":"Gounni","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2009.07.039_bib28","first-page":"940","article-title":"Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc epsilon RI): role in asthma","volume":"15","author":"Gounni","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2009.07.039_bib29","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1172\/JCI119624","article-title":"High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines","volume":"100","author":"Uguccioni","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.07.039_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-7961-3-9","article-title":"The basophil activation test by flow cytometry: recent developments in clinical studies, standardization and emerging perspectives","volume":"3","author":"Boumiza","year":"2005","journal-title":"Clin Mol Allergy"},{"key":"10.1016\/j.jaci.2009.07.039_bib31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0035-9203(69)90011-X","article-title":"Serological reactions to infection with Necator americanus","volume":"63","author":"Ball","year":"1969","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jaci.2009.07.039_bib32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/315577a0","article-title":"Inhibition of the Prausnitz-Kustner reaction by an immunoglobulin epsilon-chain fragment synthesized in E. coli","volume":"315","author":"Geha","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2009.07.039_bib33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0035-9203(78)90303-6","article-title":"Antibody responses in self-infections with Necator americanus","volume":"72","author":"Ogilvie","year":"1978","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jaci.2009.07.039_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.1987.37.126","article-title":"The clinical and immunologic responses of normal human volunteers to low dose hookworm (Necator americanus) infection","volume":"37","author":"Maxwell","year":"1987","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jaci.2009.07.039_bib35","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2249.2005.02945.x","article-title":"Immune responses following experimental human hookworm infection","volume":"142","author":"Wright","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib36","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/jcm.26.4.739-742.1988","article-title":"Role of specific immunoglobulin E to excretory-secretory antigen in diagnosis and prognosis of hookworm infection","volume":"26","author":"Ganguly","year":"1988","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaci.2009.07.039_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-3024.1995.tb00968.x","article-title":"Immunity in humans to Necator americanus: IgE, parasite weight and fecundity","volume":"17","author":"Pritchard","year":"1995","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib38","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.4049\/jimmunol.172.4.2439","article-title":"Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections","volume":"172","author":"Mitre","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1067\/mai.2001.117175","article-title":"Basophil recruitment and IL-4 production during human allergen-induced late asthma","volume":"108","author":"Nouri-Aria","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib40","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0091-6749(99)70292-7","article-title":"Frequency and characterization of antigen-specific IL-4- and IL-13- producing basophils and T cells in peripheral blood of healthy and asthmatic subjects","volume":"104","author":"Devouassoux","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1067\/mai.2002.125828","article-title":"IgE(+), Kit(-), I-A\/I-E(-) myeloid cells are the initial source of Il-4 after antigen challenge in a mouse model of allergic pulmonary inflammation","volume":"110","author":"Luccioli","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_bib42","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1084\/jem.20040590","article-title":"Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite","volume":"200","author":"Min","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.07.039_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1189\/jlb.0702356","article-title":"Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites","volume":"73","author":"Phillips","year":"2003","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2009.07.039_bib44","first-page":"307","article-title":"Limiting concentrations of human basophil-bound IgE antibody required for histamine release","volume":"64","author":"Pruzansky","year":"1988","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2009.07.039_bib45","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.jaci.2005.12.1341","article-title":"IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections","volume":"117","author":"Mitre","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.07.039_e46","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-2222.2007.02919.x","article-title":"A rapid two-step procedure for the purification of human peripheral blood basophils to near homogeneity","volume":"38","author":"Gibbs","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2009.07.039_e47","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0035-9203(69)90011-X","article-title":"Serological reactions to infection with Necator americanus","volume":"63","author":"Ball","year":"1969","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jaci.2009.07.039_e48","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0035-9203(78)90303-6","article-title":"Antibody responses in self-infections with Necator americanus","volume":"72","author":"Ogilvie","year":"1978","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jaci.2009.07.039_e49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.4269\/ajtmh.1984.33.387","article-title":"Larvicidal activity of albendazole against Necator americanus in human volunteers","volume":"33","author":"Cline","year":"1984","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jaci.2009.07.039_e50","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/infdis\/154.5.778","article-title":"Changes in the structural and functional properties of human eosinophils during experimental hookworm infection","volume":"154","author":"White","year":"1986","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2009.07.039_e51","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.1987.37.126","article-title":"The clinical and immunologic responses of normal human volunteers to low dose hookworm (Necator americanus) infection","volume":"37","author":"Maxwell","year":"1987","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jaci.2009.07.039_e52","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/jcm.26.4.739-742.1988","article-title":"Role of specific immunoglobulin E to excretory-secretory antigen in diagnosis and prognosis of hookworm infection","volume":"26","author":"Ganguly","year":"1988","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaci.2009.07.039_e53","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2249.2005.02945.x","article-title":"Immune responses following experimental human hookworm infection","volume":"142","author":"Wright","year":"2005","journal-title":"Clin Exp Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909011488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909011488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:18:46Z","timestamp":1758788326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674909011488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0091674909011488"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.07.039","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.07.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}