{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:01:05Z","timestamp":1779282065526,"version":"3.51.4"},"reference-count":78,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.jaci.2009.08.038","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T07:33:33Z","timestamp":1257406413000},"page":"1088-1098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis"],"prefix":"10.1016","volume":"124","author":[{"given":"Laurie E.","family":"Lenox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Kambayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph M.","family":"Bunte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha S.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Koretzky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim E.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2009.08.038_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/clim.2001.5007","article-title":"The neutrophil: function and regulation in innate and humoral immunity","volume":"99","author":"Burg","year":"2001","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib2","first-page":"218","article-title":"Integrated signalling pathways for mast-cell activation","volume":"6","author":"Gilfillan","year":"2006","journal-title":"Nat Rev"},{"key":"10.1016\/j.jaci.2009.08.038_bib3","first-page":"205","article-title":"IgE in allergy and asthma today","volume":"8","author":"Gould","year":"2008","journal-title":"Nat Rev"},{"key":"10.1016\/j.jaci.2009.08.038_bib4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/11024150260102807","article-title":"Role of the neutrophil in septic shock and the adult respiratory distress syndrome","volume":"168","author":"Aldridge","year":"2002","journal-title":"Eur J Surg"},{"key":"10.1016\/j.jaci.2009.08.038_bib5","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.4049\/jimmunol.167.3.1601","article-title":"Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis","volume":"167","author":"Wipke","year":"2001","journal-title":"J Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2009.08.038_bib6","doi-asserted-by":"crossref","first-page":"B24","DOI":"10.1038\/35037021","article-title":"Signalling through the high-affinity IgE receptor Fc epsilonRI","volume":"402","author":"Turner","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2009.08.038_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1385\/CRIAI:22:2:149","article-title":"The diverse effects of mast cell mediators","volume":"22","author":"Hines","year":"2002","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.immunol.19.1.275","article-title":"IgG Fc receptors","volume":"19","author":"Ravetch","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0898-6568(99)00003-0","article-title":"Integrin signalling in neutrophils and macrophages","volume":"11","author":"Berton","year":"1999","journal-title":"Cell Signal"},{"key":"10.1016\/j.jaci.2009.08.038_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-065X.2007.00541.x","article-title":"Compartmentalization of ITAM and integrin signaling by adapter molecules","volume":"218","author":"Bezman","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2009.08.038_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ni0203-110","article-title":"Adaptors as central mediators of signal transduction in immune cells","volume":"4","author":"Jordan","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib12","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.molimm.2004.04.010","article-title":"Src-family kinases: rheostats of immune cell signaling","volume":"41","author":"Lowell","year":"2004","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib13","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/ni1407","article-title":"Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs","volume":"7","author":"Mocsai","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.021908.132706","article-title":"T cell activation","volume":"27","author":"Smith-Garvin","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib15","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.4049\/jimmunol.178.7.4606","article-title":"Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing","volume":"178","author":"Clemens","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib16","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1128\/MCB.23.7.2395-2406.2003","article-title":"Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells","volume":"23","author":"Kettner","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2009.08.038_bib17","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S1074-7613(03)00305-4","article-title":"SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils","volume":"19","author":"Newbrough","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.08.038_bib18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0952-7915(02)00396-5","article-title":"Molecular adapters in Fc(epsilon)RI signaling and the allergic response","volume":"14","author":"Rivera","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib19","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.4049\/jimmunol.172.11.6768","article-title":"Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function","volume":"172","author":"Wu","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib20","doi-asserted-by":"crossref","first-page":"19641","DOI":"10.1074\/jbc.271.33.19641","article-title":"Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function","volume":"271","author":"Bubeck Wardenburg","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2009.08.038_bib21","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.4049\/jimmunol.157.9.3769","article-title":"Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity","volume":"157","author":"Fang","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib22","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.4049\/jimmunol.176.4.2430","article-title":"Functional hierarchy of the N-terminal tyrosines of SLP-76","volume":"176","author":"Jordan","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.immuni.2008.01.010","article-title":"Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76","volume":"28","author":"Jordan","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.08.038_bib24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.281.5375.416","article-title":"Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development","volume":"281","author":"Clements","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jaci.2009.08.038_bib25","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1128\/MCB.26.5.1826-1838.2006","article-title":"Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells","volume":"26","author":"Silverman","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2009.08.038_bib26","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1182\/blood-2002-07-2346","article-title":"G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells","volume":"101","author":"Mocsai","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.08.038_bib27","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1083\/jcb.133.4.895","article-title":"Deficiency of Src family kinases p59\/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions","volume":"133","author":"Lowell","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2009.08.038_bib28","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.1128\/MCB.01040-06","article-title":"Evidence for the requirement of ITAM domains but not SLP-76\/Gads interaction for integrin signaling in hematopoietic cells","volume":"26","author":"Abtahian","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2009.08.038_bib29","doi-asserted-by":"crossref","unstructured":"Monach PA MD, Benoist C. The K\/BxN arthritis model. Curr Protoc Immunol 2008. Chapter 15:Unit 15.22.","DOI":"10.1002\/0471142735.im1522s81"},{"key":"10.1016\/j.jaci.2009.08.038_bib30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1074-7613(00)80658-5","article-title":"Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76","volume":"9","author":"Bubeck Wardenburg","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.08.038_bib31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1074-7613(00)80422-7","article-title":"Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta\/CD3 induction of interleukin-2","volume":"6","author":"Raab","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.08.038_bib32","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1084\/jem.184.3.1161","article-title":"p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells","volume":"184","author":"Tuosto","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.08.038_bib33","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S1074-7613(00)80485-9","article-title":"Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation","volume":"4","author":"Wu","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.08.038_bib34","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/(SICI)1521-4141(199904)29:04<1068::AID-IMMU1068>3.0.CO;2-P","article-title":"Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes","volume":"29","author":"Wunderlich","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib35","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1074\/jbc.275.3.2219","article-title":"Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade","volume":"275","author":"Bunnell","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaci.2009.08.038_bib36","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3702::AID-IMMU3702>3.0.CO;2-R","article-title":"Interaction of SLP adaptors with the SH2 domain of Tec family kinases","volume":"29","author":"Su","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000078339","article-title":"The role of Tec family kinases in myeloid cells","volume":"134","author":"Schmidt","year":"2004","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib38","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1182\/blood-2007-07-104018","article-title":"Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation","volume":"111","author":"von Kockritz-Blickwede","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.08.038_bib39","first-page":"1737","article-title":"SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells","volume":"103","author":"Pivniouk","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.08.038_bib40","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1189\/jlb.1003498","article-title":"Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK","volume":"76","author":"Boudreau","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2009.08.038_bib41","doi-asserted-by":"crossref","first-page":"802","DOI":"10.4049\/jimmunol.163.2.802","article-title":"Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac\/c-Jun N-terminal kinase-dependent pathway","volume":"163","author":"Song","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib42","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.immunol.021908.132554","article-title":"The ins and outs of leukocyte integrin signaling","volume":"27","author":"Abram","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib43","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1084\/jem.20080240","article-title":"Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo","volume":"205","author":"Bezman","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.08.038_bib44","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1172\/JCI115570","article-title":"Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited","volume":"89","author":"Argenbright","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.08.038_bib45","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3181\/00379727-115-28889","article-title":"Inhibition of the local hemorrhagic Shwartzman reaction by a polypeptide possessing potent antiprotease activity","volume":"115","author":"Halpern","year":"1964","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.jaci.2009.08.038_bib46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.immuni.2006.05.014","article-title":"Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy","volume":"25","author":"Hirahashi","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.08.038_bib47","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.4049\/jimmunol.180.7.5083","article-title":"Destructive arthritis in the absence of both FcgammaRI and FcgammaRIII","volume":"180","author":"Boross","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib48","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.4049\/jimmunol.169.11.6604","article-title":"The role of FcgammaR signaling in the K\/B x N serum transfer model of arthritis","volume":"169","author":"Corr","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib49","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1002\/art.23757","article-title":"Vav\/phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis","volume":"58","author":"Cremasco","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.08.038_bib50","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.20081859","article-title":"Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis","volume":"206","author":"Jakus","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.08.038_bib51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1074-7613(02)00275-3","article-title":"Arthritis critically dependent on innate immune system players","volume":"16","author":"Ji","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.08.038_bib52","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1126\/science.1073176","article-title":"Mast cells: a cellular link between autoantibodies and inflammatory arthritis","volume":"297","author":"Lee","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jaci.2009.08.038_bib53","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0610852103","article-title":"Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1","volume":"104","author":"Nigrovic","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2009.08.038_bib54","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1002\/eji.200526167","article-title":"A crucial role for macrophages in the pathology of K\/B x N serum-induced arthritis","volume":"35","author":"Solomon","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib55","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.4049\/jimmunol.174.6.3668","article-title":"Manifestations of inflammatory arthritis are critically dependent on LFA-1","volume":"174","author":"Watts","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib56","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1074-7613(00)80045-X","article-title":"From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins","volume":"10","author":"Korganow","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.08.038_bib57","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0092-8674(00)81989-3","article-title":"Organ-specific disease provoked by systemic autoimmunity","volume":"87","author":"Kouskoff","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2009.08.038_bib58","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1126\/science.286.5445.1732","article-title":"Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme","volume":"286","author":"Matsumoto","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jaci.2009.08.038_bib59","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1084\/jem.187.8.1235","article-title":"Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production","volume":"187","author":"Hata","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.08.038_bib60","doi-asserted-by":"crossref","first-page":"10979","DOI":"10.1074\/jbc.273.18.10979","article-title":"Bruton's tyrosine kinase-mediated interleukin-2 gene activation in mast cells. Dependence on the c-Jun N-terminal kinase activation pathway","volume":"273","author":"Hata","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2009.08.038_bib61","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.4049\/jimmunol.161.4.1795","article-title":"Multiple signaling pathways for the activation of JNK in mast cells: involvement of Bruton's tyrosine kinase, protein kinase C, and JNK kinases, SEK1 and MKK7","volume":"161","author":"Kawakami","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib62","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jlb.65.3.286","article-title":"Functions of Bruton's tyrosine kinase in mast and B cells","volume":"65","author":"Kawakami","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2009.08.038_bib63","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.4049\/jimmunol.181.11.7706","article-title":"The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells","volume":"181","author":"Kuehn","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib64","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.20021806","article-title":"Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells","volume":"197","author":"Gonzalez-Espinosa","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.08.038_bib65","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.micinf.2003.09.008","article-title":"Neutrophil granules and secretory vesicles in inflammation","volume":"5","author":"Faurschou","year":"2003","journal-title":"Microbes and Infection\/Institut Pasteur"},{"key":"10.1016\/j.jaci.2009.08.038_bib66","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1189\/jlb.71.4.701","article-title":"Signaling to localized degranulation in neutrophils adherent to immune complexes","volume":"71","author":"Naucler","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2009.08.038_bib67","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0167-4889(94)90236-4","article-title":"Role of protein phosphorylation in the degranulation of electropermeabilized human neutrophils","volume":"1223","author":"Niessen","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jaci.2009.08.038_bib68","first-page":"541","article-title":"Neutrophil serine proteases: specific regulators of inflammation","volume":"6","author":"Pham","year":"2006","journal-title":"Nat Rev"},{"key":"10.1016\/j.jaci.2009.08.038_bib69","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0167-4889(90)90068-O","article-title":"Ca2(+)-induced secretion by electropermeabilized human neutrophils. The roles of Ca2+, nucleotides and protein kinase C","volume":"1052","author":"Smolen","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jaci.2009.08.038_bib70","doi-asserted-by":"crossref","first-page":"C1690","DOI":"10.1152\/ajpcell.00384.2006","article-title":"The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets","volume":"292","author":"Jog","year":"2007","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jaci.2009.08.038_bib71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.imlet.2005.11.001","article-title":"ITAM-based signaling beyond the adaptive immune response","volume":"104","author":"Fodor","year":"2006","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaci.2009.08.038_bib72","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1182\/blood-2007-11-126029","article-title":"Fc{gamma}R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome","volume":"112","author":"Tian","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.08.038_bib73","doi-asserted-by":"crossref","first-page":"7694","DOI":"10.4049\/jimmunol.172.12.7694","article-title":"Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes","volume":"172","author":"Wipke","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.08.038_bib74","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1016-8478(23)17551-0","article-title":"CD4+CD25+ regulatory T cells selectively diminish systemic autoreactivity in arthritic K\/BxN mice","volume":"25","author":"Kang","year":"2008","journal-title":"Mol Cells"},{"key":"10.1016\/j.jaci.2009.08.038_bib75","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20041400","article-title":"NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production","volume":"201","author":"Kim","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.08.038_bib76","first-page":"2484","article-title":"FcgammaRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation","volume":"116","author":"Kim","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.08.038_bib77","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","article-title":"Rheumatoid arthritis","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2009.08.038_bib78","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.immuni.2008.10.019","article-title":"Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells","volume":"30","author":"Victoratos","year":"2009","journal-title":"Immunity"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909013207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909013207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:19:42Z","timestamp":1758788382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674909013207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0091674909013207"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.08.038","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.08.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}