{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:13:49Z","timestamp":1790745229140,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.jaci.2009.09.054","type":"journal-article","created":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T04:31:11Z","timestamp":1265949071000},"page":"469-476.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Differential roles for the IL-9\/IL-9 receptor \u03b1-chain pathway in systemic and oral antigen\u2013induced anaphylaxis"],"prefix":"10.1016","volume":"125","author":[{"given":"Heather","family":"Osterfeld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Strait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred D.","family":"Finkelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Renauld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl","key":"10.1016\/j.jaci.2009.09.054_bib1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jaci.2007.05.001","article-title":"Risk assessment in anaphylaxis: current and future approaches","volume":"120","author":"Simons","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jaci.2005.03.017","article-title":"Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects","volume":"116","author":"Sicherer","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2009.09.054_bib3","doi-asserted-by":"crossref","first-page":"S464","DOI":"10.1016\/j.jaci.2005.11.002","article-title":"Drug Allergy","volume":"117","author":"Greenberger","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1067\/mai.2001.112031","article-title":"Fatalities due to anaphylactic reactions to foods","volume":"107","author":"Bock","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1365-2222.2007.02682.x","article-title":"Food anaphylaxis","volume":"37","author":"Wang","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2009.09.054_bib6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jaci.2007.07.033","article-title":"Anaphylaxis: lessons from mouse models","volume":"120","author":"Finkelman","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib7","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1067\/mai.2002.123302","article-title":"Pathways of anaphylaxis in the mouse","volume":"109","author":"Strait","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.immuni.2008.02.008","article-title":"Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis","volume":"28","author":"Tsujimura","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.09.054_bib9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1034\/j.1399-3038.2002.01015.x","article-title":"T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells","volume":"13","author":"Eigenmann","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-4615-5855-2_29","article-title":"Human T cell clones and cell lines specific to ovomucoid recognize different domains and consistently express IL-5","volume":"409","author":"Eigenmann","year":"1996","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jaci.2009.09.054_bib11","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1172\/JCI200316142","article-title":"Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts","volume":"111","author":"Turcanu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.09.054_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000078384","article-title":"IL-9 in allergic inflammation","volume":"134","author":"Hauber","year":"2004","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1172\/JCI0213696","article-title":"Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology","volume":"109","author":"Temann","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.09.054_bib14","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.188.7.1307","article-title":"Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness","volume":"188","author":"Temann","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.09.054_bib15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1165\/ajrcmb.19.5.3457","article-title":"Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice","volume":"19","author":"McLane","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2009.09.054_bib16","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1084\/jem.189.9.1413","article-title":"Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population","volume":"189","author":"Vink","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.09.054_bib17","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/eji.1830230743","article-title":"Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes","volume":"23","author":"Dugas","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib18","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1084\/jem.20071046","article-title":"IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity","volume":"205","author":"Forbes","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.09.054_bib19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4049\/jimmunol.175.1.335","article-title":"IL-9 promotes but is not necessary for systemic anaphylaxis","volume":"175","author":"Knoops","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1074-7613(00)00056-X","article-title":"IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development","volume":"13","author":"Townsend","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.09.054_bib21","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1084\/jem.189.10.1573","article-title":"Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG","volume":"189","author":"Ujike","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.09.054_bib22","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/eji.1830140907","article-title":"Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE","volume":"14","author":"Baniyash","year":"1984","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib23","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/eji.1830140907","article-title":"Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE","volume":"14","author":"Baniyash","year":"1984","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4049\/jimmunol.126.2.680","article-title":"IgD-secreting murine plasmacytomas: identification and partial characterization of two IgD myeloma proteins","volume":"126","author":"Finkelman","year":"1981","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib25","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1172\/JCI25575","article-title":"IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking","volume":"116","author":"Strait","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.09.054_bib26","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.4049\/jimmunol.170.7.3835","article-title":"IL-4 exacerbates anaphylaxis","volume":"170","author":"Strait","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib27","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1172\/JCI19785","article-title":"Mast cells are required for experimental oral allergen-induced diarrhea","volume":"112","author":"Brandt","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2009.09.054_bib28","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.4049\/jimmunol.160.8.3989","article-title":"Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice","volume":"160","author":"Godfraind","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib29","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.170.7.3461","article-title":"IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor","volume":"170","author":"Matsuzawa","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib30","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.4049\/jimmunol.147.4.1387","article-title":"Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis","volume":"147","author":"Madden","year":"1991","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib31","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/ni.1677","article-title":"IL-4 inhibits TGF-beta-induced Foxp3 + T cells and, together with TGF-beta, generates IL-9 + IL-10 + Foxp3(-) effector T cells","volume":"9","author":"Dardalhon","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2009.09.054_bib32","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1084\/jem.20021340","article-title":"Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen","volume":"196","author":"Eisenbarth","year":"2002","journal-title":"J Exp Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167490901553X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167490901553X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:20:08Z","timestamp":1758788408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167490901553X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S009167490901553X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.09.054","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential roles for the IL-9\/IL-9 receptor \u03b1-chain pathway in systemic and oral antigen\u2013induced anaphylaxis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.09.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}