{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:34:39Z","timestamp":1791128079876,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009318","name":"Helmholtz Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.jaci.2009.10.025","type":"journal-article","created":{"date-parts":[[2010,1,2]],"date-time":"2010-01-02T04:03:56Z","timestamp":1262405036000},"page":"237-246.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8+ T cells"],"prefix":"10.1016","volume":"125","author":[{"given":"Sabine","family":"Ring","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Karakhanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theron","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander H.","family":"Enk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Mahnke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2009.10.025_bib1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib2","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1182\/blood-2003-03-0727","article-title":"Innate CD4+ CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation","volume":"102","author":"Dubois","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.10.025_bib3","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1002\/eji.200636207","article-title":"CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue","volume":"36","author":"Ring","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jim.2007.06.007","article-title":"Expanded murine regulatory T\u00a0cells: analysis of phenotype and function in contact hypersensitivity reactions","volume":"326","author":"Ring","year":"2007","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2009.10.025_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.immuni.2006.04.017","article-title":"Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming","volume":"25","author":"Allan","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.10.025_bib6","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1084\/jem.20071966","article-title":"Identification of a novel population of Langerin+ dendritic cells","volume":"204","author":"Bursch","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.10.025_bib7","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib8","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/eji.200636841","article-title":"Induction of immunosuppressive functions of dendritic cells in vivo by CD4+ CD25+ regulatory T cells: role of B7-H3 expression and antigen presentation","volume":"37","author":"Mahnke","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib9","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.4049\/jimmunol.172.8.4676","article-title":"Cutting edge: human CD4+ CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells","volume":"172","author":"Misra","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib10","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.4049\/jimmunol.176.10.6202","article-title":"Modulation of dendritic cell function by naive and regulatory CD4+ T cells","volume":"176","author":"Veldhoen","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib11","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.20062129","article-title":"Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression","volume":"204","author":"Bopp","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.10.025_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4049\/jimmunol.176.1.181","article-title":"Gap junction-mediated intercellular communication between dendritic cells (DCs) is required for effective activation of DCs","volume":"176","author":"Matsue","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib13","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.4049\/jimmunol.178.11.6949","article-title":"Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells","volume":"178","author":"Mendoza-Naranjo","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib14","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1046\/j.1365-2567.2000.00991.x","article-title":"Intercellular communication in the immune system: differential expression of connexin 40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations","volume":"99","author":"Oviedo-Orta","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2009.10.025_bib15","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.10.025_bib16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/jid.2008.304","article-title":"IL-10-producing Langerhans cells and regulatory T cells are responsible for depressed contact hypersensitivity in grafted skin","volume":"129","author":"Yoshiki","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2009.10.025_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/15419060801891034","article-title":"Mimetic peptides as blockers of connexin channel-facilitated intercellular communication","volume":"14","author":"Evans","year":"2007","journal-title":"Cell Commun Adhes"},{"key":"10.1016\/j.jaci.2009.10.025_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4049\/jimmunol.177.1.40","article-title":"Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells","volume":"177","author":"Kryczek","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib19","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ni1003","article-title":"Modulation of tryptophan catabolism by regulatory T cells","volume":"4","author":"Fallarino","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib20","doi-asserted-by":"crossref","first-page":"10113","DOI":"10.1073\/pnas.0711106105","article-title":"Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation","volume":"105","author":"Onishi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2009.10.025_bib21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ni1289","article-title":"Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice","volume":"7","author":"Tang","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib22","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.4049\/jimmunol.174.12.7487","article-title":"Cutting edge: CD4+ CD25+ regulatory T cells impaired for intestinal homing can prevent colitis","volume":"174","author":"Denning","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib23","doi-asserted-by":"crossref","first-page":"6993","DOI":"10.4049\/jimmunol.174.11.6993","article-title":"Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells","volume":"174","author":"Ochando","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib24","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1084\/jem.20061405","article-title":"CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells","volume":"204","author":"Schneider","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.10.025_bib25","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1084\/jem.190.7.995","article-title":"An essential role for interleukin-10 in the function of regulatory T cells that inhibit intestinal inflammation","volume":"190","author":"Asseman","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.10.025_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/intimm\/dxh029","article-title":"IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+ CD4+ regulatory T cells","volume":"16","author":"Zhang","year":"2004","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib27","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.4049\/jimmunol.159.10.4772","article-title":"Induction of tolerance by IL-10-treated dendritic cells","volume":"159","author":"Steinbrink","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature03290","article-title":"Cross-presentation by intercellular peptide transfer through gap junctions","volume":"434","author":"Neijssen","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2009.10.025_bib29","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/eji.1830270627","article-title":"Direct cell\/cell communication in the lymphoid germinal center: connexin43 gap junctions functionally couple follicular dendritic cells to each other and to B lymphocytes","volume":"27","author":"Krenacs","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib30","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1096\/fj.00-0288com","article-title":"Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication","volume":"15","author":"Oviedo-Orta","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2009.10.025_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1017\/S1740925X08000069","article-title":"Connexin and pannexin mediated cell-cell communication","volume":"3","author":"Scemes","year":"2007","journal-title":"Neuron Glia Biol"},{"key":"10.1016\/j.jaci.2009.10.025_bib32","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1073\/pnas.022324499","article-title":"Function of the voltage gate of gap junction channels: selective exclusion of molecules","volume":"99","author":"Qu","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2009.10.025_bib33","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pbiomolbio.2007.03.011","article-title":"Connexin channel permeability to cytoplasmic molecules","volume":"94","author":"Harris","year":"2007","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.jaci.2009.10.025_bib34","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1084\/jem.20080912","article-title":"Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function","volume":"206","author":"la","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.10.025_bib35","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.4049\/jimmunol.171.12.6421","article-title":"Cyclic nucleotides promote monocyte differentiation toward a DC-SIGN+ (CD209) intermediate cell and impair differentiation into dendritic cells","volume":"171","author":"Giordano","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib36","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.1182\/blood-2008-05-156646","article-title":"Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation","volume":"112","author":"Li","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.10.025_bib37","doi-asserted-by":"crossref","first-page":"20920","DOI":"10.1074\/jbc.M600026200","article-title":"Enhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATP","volume":"281","author":"Belliveau","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2009.10.025_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1096\/fj.00-0566fje","article-title":"Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells","volume":"15","author":"Bruzzone","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2009.10.025_bib39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1085\/jgp.200709934","article-title":"Gap junction channels exhibit connexin-specific permeability to cyclic nucleotides","volume":"131","author":"Kanaporis","year":"2008","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.jaci.2009.10.025_bib40","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.RES.0000250174.31269.70","article-title":"ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function","volume":"99","author":"Eltzschig","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.jaci.2009.10.025_bib41","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nm1441","article-title":"Connexin37 protects against atherosclerosis by regulating monocyte adhesion","volume":"12","author":"Wong","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2009.10.025_bib42","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood-2006-12-064527","article-title":"Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression","volume":"110","author":"Borsellino","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2009.10.025_bib43","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"Deaglio","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.10.025_bib44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4049\/jimmunol.182.1.274","article-title":"Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity","volume":"182","author":"Schmidt","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib45","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.4049\/jimmunol.0801711","article-title":"NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells","volume":"182","author":"Scheuplein","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib46","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S1074-7613(00)00066-2","article-title":"On the dynamics of TCR: CD3 complex cell surface expression and downmodulation","volume":"13","author":"Liu","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2009.10.025_bib47","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.4049\/jimmunol.175.12.7829","article-title":"CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse","volume":"175","author":"Tseng","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2009.10.025_bib48","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.4049\/jimmunol.157.8.3270","article-title":"Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation","volume":"157","author":"Doty","year":"1996","journal-title":"J\u00a0Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909015541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909015541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:19:58Z","timestamp":1758788398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674909015541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0091674909015541"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.10.025","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8+ T cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.10.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}