{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T19:04:43Z","timestamp":1782327883612,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.jaci.2009.10.067","type":"journal-article","created":{"date-parts":[[2010,2,21]],"date-time":"2010-02-21T04:28:54Z","timestamp":1266726534000},"page":"S204-S215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"special_numbering":"S2","title":["Immunologic rheumatic disorders"],"prefix":"10.1016","volume":"125","author":[{"given":"Amy","family":"Joseph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Brasington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Kahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabha","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy P.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2009.10.067_bib1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2009.10.067_bib2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","article-title":"Rheumatoid arthritis","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2009.10.067_bib3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/art.10148","article-title":"Guidelines for the management of rheumatoid arthritis 2002 update. American College of Rheumatology subcommittee on rheumatoid arthritis guidelines","volume":"46","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.10.067_bib4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0889-857X(05)70042-9","article-title":"Bowel inflammation and the spondyloarthropathies","volume":"24","author":"DeKeyser","year":"1998","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.jaci.2009.10.067_bib5","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0016-5085(00)70209-5","article-title":"Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease","volume":"118","author":"Orchard","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2009.10.067_bib6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1468-3083.2009.03159.x","article-title":"Prevalence and clinical features of psoriatic arthritis and joint complaints in 2009 patients with psoriasis: results of a German national survey","volume":"23","author":"Radtke","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2009.10.067_bib7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/0092-8674(90)90512-D","article-title":"Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2 m: an animal model of HLA-B27-associated human disorders","volume":"63","author":"Hammer","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2009.10.067_bib8","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1084\/jem.180.6.2359","article-title":"The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats","volume":"180","author":"Taurog","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2009.10.067_bib9","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/art.1780341003","article-title":"The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy","volume":"34","author":"Dougados","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.10.067_bib10","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/art.23471","article-title":"Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept","volume":"58","author":"van der Heijde","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.10.067_bib11","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1002\/art.23901","article-title":"Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis","volume":"58","author":"van der Heijde","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.10.067_bib12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/ard.2005.041137","article-title":"ASAS\/EULAR recommendations for the management of ankylosing spondylitis","volume":"65","author":"Zochling","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2009.10.067_bib13","first-page":"1785","article-title":"Hoc Committee on SLE Guidelines. Guidelines for referral and management of SLE in adults","volume":"42","author":"Ad","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.10.067_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5858\/2000-124-0071-GFCUOT","article-title":"Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists","volume":"124","author":"Kavanaugh","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jaci.2009.10.067_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jaci.2009.10.067_bib16","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/jama.295.9.1050","article-title":"Management of antiphospholipid antibody syndrome: a systematic review","volume":"295","author":"Lim","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2009.10.067_bib17","series-title":"Sjogren's syndrome","first-page":"1681","article-title":"Arthritis and allied conditions","author":"Jonsson","year":"2005"},{"key":"10.1016\/j.jaci.2009.10.067_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The Definition and Classification of Dry Eye Disease: Report of the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007)","volume":"5","year":"2007","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jaci.2009.10.067_bib19","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.rdc.2008.08.012","article-title":"Pulmonary manifestations of primary Sjogren's syndrome","volume":"34","author":"Parke","year":"2008","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.jaci.2009.10.067_bib20","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1164\/rccm.200403-417OC","article-title":"Pulmonary manifestations of primary Sjogren's syndrome: a clinical, radiologic and pathologic study","volume":"171","author":"Ito","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2009.10.067_bib21","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.rdc.2008.08.001","article-title":"Involvement of nervous system pathways in primary Sjogren's syndrome","volume":"34","author":"Segal","year":"2008","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.jaci.2009.10.067_bib22","first-page":"199","article-title":"The spectrum of benign to malignant lymphoproliferation in Sjogren's syndrome","volume":"10","author":"Anderson","year":"1972","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2009.10.067_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/10428199909093729","article-title":"Lymphomas in patients with Sjogren's syndrome: review of the literature and physiopathologic hypothesis","volume":"33","author":"Mariette","year":"1999","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.jaci.2009.10.067_bib24","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/art.20176","article-title":"Mortality and causes of death in primary Sjogren's syndrome: a prospective cohort study","volume":"50","author":"Theander","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.10.067_bib25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/art.10221","article-title":"Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjogren's syndrome","volume":"46","author":"Ioannidis","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.10.067_bib26","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/ard.2005.041186","article-title":"Lymphoma and other malignancies in primary Sjogren's syndrome: a cohort study on cancer incidence and lymphoma predictors","volume":"65","author":"Theander","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2009.10.067_bib27","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1001\/archinte.165.20.2337","article-title":"The risk of lymphoma development in autoimmune diseases: a meta-analysis","volume":"165","author":"Zintzaras","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jaci.2009.10.067_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1191\/0961203306lu2290rr","article-title":"The role of epithelial cells in the initiation and perpetuation of autoimmune lesions: lessons from Sjogren's syndrome (autoimmune epithelitis)","volume":"15","author":"Mitsias","year":"2006","journal-title":"Lupus"},{"key":"10.1016\/j.jaci.2009.10.067_bib29","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S1568-9972(02)00057-5","article-title":"Brito Zeron MP, Cervera R, Font J. Viral etiopathogenesis of Sjogren's syndrome: role of the hepatitis C virus","volume":"1","author":"Ramos-Casals","year":"2002","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaci.2009.10.067_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/030097400447525","article-title":"Current concepts on diagnosis, autoantibodies and therapy in Sjogren's syndrome","volume":"29","author":"Jonsson","year":"2000","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jaci.2009.10.067_bib31","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2009.10.067_bib32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/archinte.159.2.174","article-title":"Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjogren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group","volume":"159","author":"Vivino","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jaci.2009.10.067_bib33","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/art.510","article-title":"A double-blind, randomized, placebo-controlled study of cevimeline in Sjogren's syndrome patients with xerostomia and keratoconjunctivitis sicca","volume":"46","author":"Petrone","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2009.10.067_bib34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/ard.2006.057919","article-title":"Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjogren's syndrome","volume":"66","author":"Seror","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2009.10.067_bib35","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1136\/ard.2007.083865","article-title":"Reduction of fatigue in Sjogren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study","volume":"67","author":"Dass","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2009.10.067_bib36","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1136\/ard.2007.079921","article-title":"Tracleer use in PAH associated with scleroderma and connective tissue diseases (TRUST) investigators","volume":"67","author":"Denton","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2009.10.067_bib37","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1056\/NEJMoa055120","article-title":"Cyclophosphamide versus placebo in scleroderma lung disease","volume":"354","author":"Tashkin","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2009.10.067_bib38","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJM199111213252107","article-title":"Polymyositis, dermatomyositis and inclusion-body myositis","volume":"1991","author":"Dalakas","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2009.10.067_bib39","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/archderm.138.7.885","article-title":"Routine vs extensive malignancy search for adult dermatomyositis and polymyositis: a study of 40 patients","volume":"138","author":"Sparsa","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2009.10.067_bib40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/BOR.0b013e3283157538","article-title":"Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies","volume":"20","author":"de Padilla","year":"2008","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jaci.2009.10.067_bib41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/00002281-200111000-00004","article-title":"Myositis-specific autoantibodies: overview and recent developments","volume":"13","author":"Hengstman","year":"2001","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jaci.2009.10.067_bib42","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00005792-199111000-00002","article-title":"A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogenous patient groups","volume":"70","author":"Love","year":"1991","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaci.2009.10.067_bib43","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.nurt.2008.08.008","article-title":"Idiopathic inflammatory myopathies: current and future therapeutic options","volume":"5","author":"Wiendl","year":"2008","journal-title":"Neurotherapeutics"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909017230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674909017230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:22:18Z","timestamp":1758788538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674909017230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0091674909017230"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2009.10.067","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunologic rheumatic disorders","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2009.10.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}