{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:00:17Z","timestamp":1789657217994,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.jaci.2010.04.002","type":"journal-article","created":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T08:32:00Z","timestamp":1275381120000},"page":"1212-1217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Viral respiratory tract infections and asthma: The course ahead"],"prefix":"10.1016","volume":"125","author":[{"given":"Louis A.","family":"Rosenthal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro C.","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Heymann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Kathryn","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos G.","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"R. Stokes","family":"Peebles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2010.04.002_bib1","article-title":"Treatise on asthma","author":"Maimonides","year":"1963"},{"key":"10.1016\/j.jaci.2010.04.002_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jcv.2007.03.012","article-title":"Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis","volume":"39","author":"McErlean","year":"2007","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jaci.2010.04.002_bib3","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/JCM.01254-07","article-title":"Clinical features and\u00a0complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children","volume":"45","author":"Lau","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaci.2010.04.002_bib4","doi-asserted-by":"crossref","first-page":"e966","DOI":"10.1371\/journal.pone.0000966","article-title":"A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2010.04.002_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2008.10.007","article-title":"A\u00a0novel group of rhinoviruses is associated with asthma hospitalizations","volume":"123","author":"Miller","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.04.002_bib6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2006.12.669","article-title":"Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma","volume":"119","author":"Kusel","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.04.002_bib7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib8","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1164\/rccm.200604-489OC","article-title":"Chronic rhinoviral infection in lung transplant recipients","volume":"174","author":"Kaiser","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jaci.2004.04.006","article-title":"Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing","volume":"114","author":"Heymann","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.04.002_bib11","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1164\/rccm.200804-579OC","article-title":"Evidence of a causal role of winter virus infection during infancy in early childhood asthma","volume":"178","author":"Wu","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib12","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","article-title":"Rhinovirus illnesses during infancy predict subsequent childhood wheezing","volume":"116","author":"Lemanske","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.04.002_bib13","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1164\/rccm.200809-1471OC","article-title":"Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study","volume":"179","author":"Thomsen","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1067\/mai.2003.33","article-title":"Rhinovirus-induced wheezing in infancy\u2014the first sign of childhood asthma?","volume":"111","author":"Kotaniemi-Syrjanen","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.04.002_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1164\/rccm.200412-1693OC","article-title":"Neurotrophin overexpression in lower airways of infants with respiratory syncytial virus infection","volume":"172","author":"Tortorolo","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/ACI.0b013e32832b36cd","article-title":"Childhood asthma may be a consequence of vitamin D deficiency","volume":"9","author":"Litonjua","year":"2009","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.04.002_bib17","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jaci.2009.07.037","article-title":"The acetaminophen and asthma hypothesis 10 years on: a case to answer","volume":"124","author":"Farquhar","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.04.002_bib18","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1164\/ajrccm.159.3.9801052","article-title":"Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses","volume":"159","author":"Rakes","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1165557","article-title":"Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution","volume":"324","author":"Palmenberg","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jaci.2010.04.002_bib20","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/JVI.01853-08","article-title":"A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction","volume":"83","author":"Moore","year":"2009","journal-title":"J Virol"},{"issue":"suppl\u00a019","key":"10.1016\/j.jaci.2010.04.002_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1399-3038.2008.00767.x","article-title":"New visions in respiratory allergy (asthma and allergic rhinitis): an iPAC summary and future trends","volume":"19","author":"Papadopoulos","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2010.04.002_bib22","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1086\/520816","article-title":"Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity","volume":"196","author":"Kistler","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2010.04.002_bib23","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/bioinformatics\/btg200","article-title":"Comprehensive aligned sequence construction for automated design of effective probes (CASCADE-P) using 16S rDNA","volume":"19","author":"DeSantis","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2010.04.002_bib24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1513\/pats.200702-033AW","article-title":"Microbial manipulation of immune function for asthma prevention: inferences from clinical trials","volume":"4","author":"Yoo","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaci.2010.04.002_bib25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpeds.2007.02.032","article-title":"Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing","volume":"151","author":"Simoes","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2010.04.002_bib26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0002-9343(02)01095-1","article-title":"Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin","volume":"112","author":"Wenzel","year":"2002","journal-title":"Am J Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pharmthera.2007.11.002","article-title":"Understanding the mechanisms of viral induced asthma: new therapeutic directions","volume":"117","author":"Hansbro","year":"2008","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jaci.2010.04.002_bib28","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/thx.2005.042523","article-title":"Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children","volume":"61","author":"Murray","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2010.04.002_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMoa0808907","article-title":"Preemptive use of high-dose fluticasone for virus-induced wheezing in young children","volume":"360","author":"Ducharme","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMoa0804897","article-title":"Oral prednisolone for preschool children with acute virus-induced wheezing","volume":"360","author":"Panickar","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200407-894OC","article-title":"Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma","volume":"171","author":"Bisgaard","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1164\/rccm.200510-1546OC","article-title":"Short-course montelukast for intermittent asthma in children: a randomized controlled trial","volume":"175","author":"Robertson","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib33","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa1001278","article-title":"Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids","volume":"362","author":"Lemanske","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib34","doi-asserted-by":"crossref","first-page":"13562","DOI":"10.1073\/pnas.0804181105","article-title":"Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1\/2 cytokine and IL-10 production","volume":"105","author":"Message","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2010.04.002_bib35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nm1713","article-title":"Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation","volume":"14","author":"Bartlett","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib36","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1164\/rccm.200708-1243OC","article-title":"Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice","volume":"177","author":"Newcomb","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.04.002_bib37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1743-422X-6-122","article-title":"A rat model of picornavirus-induced airway infection and inflammation","volume":"6","author":"Rosenthal","year":"2009","journal-title":"Virol J"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910005889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910005889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:21:43Z","timestamp":1758788503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674910005889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0091674910005889"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2010.04.002","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Viral respiratory tract infections and asthma: The course ahead","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2010.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}