{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:27:59Z","timestamp":1790360879443,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.jaci.2010.05.006","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T12:15:19Z","timestamp":1309176919000},"page":"360-365.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"title":["Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: A\u00a0randomized controlled trial"],"prefix":"10.1016","volume":"128","author":[{"given":"Adrian J.","family":"Lowe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford S.","family":"Hosking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina J.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Axelrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Carlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamali C.","family":"Dharmage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2010.05.006_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/01.all.0000168791.89829.2a","article-title":"Primary prevention of food allergy in infants who are at risk","volume":"5","author":"Host","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.5694\/j.1326-5377.2005.tb06787.x","article-title":"Australasian Society of Clinical Immunology and Allergy position statement: summary of allergy prevention in children","volume":"182","author":"Prescott","year":"2005","journal-title":"Med J Aust"},{"key":"10.1016\/j.jaci.2010.05.006_bib3","first-page":"1437","article-title":"Primary allergy prevention: partially or extensively hydrolyzed infant formulas?","volume":"60","author":"Miniello","year":"2008","journal-title":"Minerva Pediatr"},{"key":"10.1016\/j.jaci.2010.05.006_bib4","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1001\/archpedi.159.9.810","article-title":"A systematic review of the role of hydrolyzed infant formulas in allergy prevention","volume":"159","author":"Hays","year":"2005","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jaci.2010.05.006_bib5","first-page":"320","article-title":"Dietary approaches to the prevention of food allergy","volume":"11","author":"Heine","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.jaci.2010.05.006_bib6","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.jaci.2009.01.045","article-title":"Update on allergies in pregnancy, lactation, and early childhood","volume":"123","author":"Pali-Scholl","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2222.1993.tb00324.x","article-title":"Bovine beta-lactoglobulin levels in hydrolysed protein formulas for infant feeding","volume":"23","author":"Makinen-Kiljunen","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2010.05.006_bib8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0091-6749(97)70235-5","article-title":"Induction of systemic immunologic tolerance to beta-lactoglobulin by oral administration of a whey protein hydrolysate","volume":"100","author":"Fritsche","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib9","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1067\/mai.2000.103049","article-title":"Peptides obtained by tryptic hydrolysis of bovine beta-lactoglobulin induce specific oral tolerance in mice","volume":"105","author":"Pecquet","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib10","first-page":"4","article-title":"Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants","author":"Osborn","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaci.2010.05.006_bib11","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1398-9995.2009.02172.x","article-title":"Infant feeding and allergy prevention: a review of current knowledge and recommendations: a EuroPrevall state of the art paper","volume":"64","author":"Grimshaw","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2010.05.006_bib12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jaci.2009.04.015","article-title":"Sublingual immunotherapy for allergic respiratory diseases: an evaluation of meta-analyses","volume":"124","author":"Nieto","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMsa065779","article-title":"Selective publication of antidepressant trials and its influence on apparent efficacy","volume":"358","author":"Turner","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2010.05.006_bib14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2010.05.006_bib15","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1067\/mai.2003.101","article-title":"The effect of hydrolyzed cow\u2019s milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial","volume":"111","author":"von Berg","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib16","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jaci.2006.11.017","article-title":"Certain hydrolyzed formulas reduce the incidence of atopic dermatitis but not that of asthma: three-year results of the German Infant Nutritional Intervention Study","volume":"119","author":"von Berg","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib17","series-title":"Complementary feeding: report of the global consultation: summary of guiding principles","year":"2002"},{"key":"10.1016\/j.jaci.2010.05.006_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000231002","article-title":"Standardization of diagnostic work in allergy","volume":"45","author":"Aas","year":"1973","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib19","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1365-2222.2007.02691.x","article-title":"The temporal sequence of allergic sensitization and onset of infantile eczema","volume":"37","author":"Lowe","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2010.05.006_bib20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0022-3476(86)80384-5","article-title":"Manifestations of milk allergy in infancy: clinical and immunologic findings","volume":"109","author":"Hill","year":"1986","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2010.05.006_bib21","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/j.1365-2222.2007.02822.x","article-title":"Skin prick test can identify eczematous infants at risk of asthma and allergic rhinitis","volume":"37","author":"Lowe","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2010.05.006_bib22","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1046\/j.1365-2222.2000.00928.x","article-title":"Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children","volume":"30","author":"Sporik","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2010.05.006_bib23","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jaci.2008.04.021","article-title":"Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI)","volume":"121","author":"von Berg","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib24","series-title":"Clinical trials: a methodologic perspective","author":"Piantadosi","year":"1997"},{"key":"10.1016\/j.jaci.2010.05.006_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1651-2227.1996.tb14267.x","article-title":"Effects of a dietary and environmental prevention programme on the incidence of allergic symptoms in high atopic risk infants: three years\u2019 follow-up","volume":"414","author":"Marini","year":"1996","journal-title":"Acta Paediatr Suppl"},{"key":"10.1016\/j.jaci.2010.05.006_bib26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/BF02029362","article-title":"The long-term effect of a partial whey hydrolysate formula on the prophylaxis of atopic disease","volume":"154","author":"Vandenplas","year":"1995","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jaci.2010.05.006_bib27","unstructured":"Lam BCC, Yeung CY. The effect of breast milk, infant formula and hypoallergenic formula on incidence of atopic manifestation in high risk infants. 6th Annual Scientific Meeting of Hong Kong College of Physicians and Hong Kong College of Paediatricians, Hong Kong 1992 (October)."},{"key":"10.1016\/j.jaci.2010.05.006_bib28","first-page":"251","article-title":"The prevention of allergic diseases with a hypoallergenic formula: a follow-up at 24 months: the preliminary results","volume":"16","author":"de Seta","year":"1994","journal-title":"Pediatr Med Chir"},{"key":"10.1016\/j.jaci.2010.05.006_bib29","first-page":"147","article-title":"Influence of hypoallergenic milk formula on the incidence of early allergic manifestations in infants predisposed to atopic diseases","volume":"71","author":"Willems","year":"1993","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jaci.2010.05.006_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jn\/135.1.1","article-title":"The immunological components of human milk and their effect on immune development in infants","volume":"135","author":"Field","year":"2005","journal-title":"J Nutr"},{"key":"10.1016\/j.jaci.2010.05.006_bib31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nm1718","article-title":"Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma","volume":"14","author":"Verhasselt","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2010.05.006_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-3038.2007.00680.x","article-title":"Dietary prevention of allergic diseases in infants and small children","volume":"19","author":"Host","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2010.05.006_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1542\/peds.2007-3022","article-title":"Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas","volume":"121","author":"Greer","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2010.05.006_bib34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2010.05.006_bib35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis","volume":"92","author":"Hanifin","year":"1980","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2010.05.006_bib36","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2133.1994.tb08532.x","article-title":"The U.K. Working Party\u2019s diagnostic criteria for atopic dermatitis, III: independent hospital validation","volume":"131","author":"Williams","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2010.05.006_bib37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/144078330003600105","article-title":"The ANU3_2 scale: a revised occupational status scale for Australia","volume":"36","author":"McMillan","year":"2000","journal-title":"J Sociol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910007402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910007402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:27:56Z","timestamp":1758788876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674910007402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0091674910007402"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2010.05.006","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: A\u00a0randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2010.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}