{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:04:15Z","timestamp":1770462255391,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.jaci.2010.06.028","type":"journal-article","created":{"date-parts":[[2010,9,4]],"date-time":"2010-09-04T06:47:06Z","timestamp":1283582826000},"page":"483-488.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life"],"prefix":"10.1016","volume":"126","author":[{"given":"Weiguo","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia M.","family":"Barb\u00e9-Tuana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrado J.","family":"Llapur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus H.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Tiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Kimmel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Kisling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangsheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Tepper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2010.06.028_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life. The Group Health Medical Associates","volume":"332","author":"Martinez","year":"1995","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2010.06.028_bib2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.06.028_bib3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1067\/mai.2001.118786","article-title":"The pattern of atopic sensitization is associated with the development of asthma in childhood","volume":"108","author":"Illi","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.06.028_bib4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1183\/09031936.02.00103602","article-title":"The effects of respiratory infections, atopy, and breastfeeding on childhood asthma","volume":"19","author":"Oddy","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2010.06.028_bib5","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1365-2222.1999.00631.x","article-title":"On early sensitization to allergens and development of respiratory symptoms","volume":"29","author":"Sherrill","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2010.06.028_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1164\/rccm.200304-499OC","article-title":"Reduced interferon \u03b3 production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age","volume":"169","author":"Guerra","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.06.028_bib7","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jaci.2007.05.050","article-title":"Low IFN-gamma production in the first year of life as a predictor of wheeze during childhood","volume":"120","author":"Stern","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.06.028_bib8","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0140-6736(08)61451-8","article-title":"Early identification of atopy in the prediction of persistent asthma in children","volume":"372","author":"Sly","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2010.06.028_bib9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jaci.2008.07.022","article-title":"Expired nitric oxide and airway reactivity in infants at risk for asthma","volume":"122","author":"Tepper","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.06.028_bib10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1164\/rccm.200406-711OC","article-title":"Parental smoking and airway reactivity in healthy infants","volume":"171","author":"Tepper","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.06.028_bib11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1398-9995.2004.00622.x","article-title":"Scoring atopic dermatitis in infants and young children: distinctive features of the SCORAD index","volume":"60","author":"Pucci","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2010.06.028_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1164\/rccm.200803-438OC","article-title":"Interleukin-10\/interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family history","volume":"179","author":"Zhang","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.06.028_bib13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jaci.2009.07.009","article-title":"Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing","volume":"124","author":"Upham","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.06.028_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ppul.1950130104","article-title":"Airway responsiveness in infants following bronchiolitis","volume":"13","author":"Tepper","year":"1992","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2010.06.028_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1378\/chest.119.3.685","article-title":"Relationship between bronchial hyperresponsiveness and development of asthma in wheezy infants","volume":"119","author":"Saga","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2010.06.028_bib16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1164\/ajrccm.151.5.7735597","article-title":"Bronchial responsiveness in the neonatal period as a risk factor for wheezing in infancy","volume":"151","author":"Clarke","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.06.028_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1164\/rccm.200805-804OC","article-title":"Childhood asthma and increased airway responsiveness: a relationship that begins in infancy","volume":"179","author":"Turner","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.06.028_bib18","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.jaci.2005.06.038","article-title":"Support for 2 variants of eczema","volume":"116","author":"Kusel","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.06.028_bib19","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1046\/j.1365-2222.2003.01749.x","article-title":"Family history and risk of atopic dermatitis in children up to 4 years","volume":"33","author":"Bohme","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2010.06.028_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1034\/j.1398-9995.2002.1n3572.x","article-title":"Natural course of AEDS","volume":"57","author":"Wuthrich","year":"2002","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910010304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910010304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:22:36Z","timestamp":1758788556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674910010304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0091674910010304"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2010.06.028","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2010.06.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}