{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:03:02Z","timestamp":1788526982742,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.jaci.2010.08.007","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T05:35:04Z","timestamp":1287034504000},"page":"1218-1225.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study"],"prefix":"10.1016","volume":"126","author":[{"given":"Mayumi","family":"Ueta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Sotozono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takazumi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Fuwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Inatomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2010.08.007_bib1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2165\/00002018-200225130-00006","article-title":"Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a review of 10 years' experience","volume":"25","author":"Forman","year":"2002","journal-title":"Drug Saf"},{"key":"10.1016\/j.jaci.2010.08.007_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/adc.83.4.347","article-title":"Diagnosis, classification, and management of erythema multiforme and Stevens-Johnson syndrome","volume":"83","author":"Leaute-Labreze","year":"2000","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2010.08.007_bib3","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1056\/NEJM199512143332404","article-title":"Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis","volume":"333","author":"Roujeau","year":"1995","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2010.08.007_bib4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ophtha.2008.12.048","article-title":"Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications","volume":"116","author":"Sotozono","year":"2009","journal-title":"Ophthalmology"},{"issue":"suppl","key":"10.1016\/j.jaci.2010.08.007_bib5","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1097\/ICO.0b013e31817f2a7f","article-title":"Innate immunity of the ocular surface and ocular surface inflammatory disorders","volume":"27","author":"Ueta","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.jaci.2010.08.007_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainresbull.2009.10.001","article-title":"Innate immunity of the ocular surface","volume":"81","author":"Ueta","year":"2010","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jaci.2010.08.007_bib7","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1136\/bjo.2006.113449","article-title":"Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome","volume":"91","author":"Ueta","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jaci.2010.08.007_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00007611-198005000-00015","article-title":"Etiologic factors of the Stevens-Johnson syndrome","volume":"73","author":"Yetiv","year":"1980","journal-title":"South Med J"},{"key":"10.1016\/j.jaci.2010.08.007_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaad.2007.08.036","article-title":"Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel","volume":"58","author":"Halevy","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2010.08.007_bib10","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1542\/peds.2008-1923","article-title":"Medications as risk factors of Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a pooled analysis","volume":"123","author":"Levi","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2010.08.007_bib11","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/S0161-6420(95)30811-1","article-title":"Analysis of the acute ophthalmic manifestations of the erythema multiforme\/Stevens-Johnson syndrome\/toxic epidermal necrolysis disease spectrum","volume":"102","author":"Power","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jaci.2010.08.007_bib12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clindermatol.2004.06.012","article-title":"Life-threatening acute adverse cutaneous drug reactions","volume":"23","author":"Wolf","year":"2005","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jaci.2010.08.007_bib13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens-Johnson syndrome","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2010.08.007_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000102045","article-title":"Stevens-Johnson syndrome, drug-induced hypersensitivity syndrome and toxic epidermal necrolysis caused by allopurinol in patients with a common HLA allele: what causes the diversity?","volume":"215","author":"Dainichi","year":"2007","journal-title":"Dermatology"},{"key":"10.1016\/j.jaci.2010.08.007_bib15","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1073\/pnas.0409500102","article-title":"HLA-B\u22175801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol","volume":"102","author":"Hung","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2010.08.007_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/FPC.0b013e3282f3ef9c","article-title":"A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs","volume":"18","author":"Lonjou","year":"2008","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.jaci.2010.08.007_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.tpj.6500356","article-title":"A marker for Stevens-Johnson syndrome.: ethnicity matters","volume":"6","author":"Lonjou","year":"2006","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.jaci.2010.08.007_bib18","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1001\/archopht.1982.01030040431012","article-title":"HLA antigens in Stevens-Johnson syndrome with ocular involvement","volume":"100","author":"Mondino","year":"1982","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jaci.2010.08.007_bib19","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/S0161-6420(96)30491-0","article-title":"HLA typing in patients with ocular manifestations of Stevens-Johnson syndrome","volume":"103","author":"Power","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jaci.2010.08.007_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1399-0039.1986.tb00491.x","article-title":"HLA phenotypes and bullous cutaneous reactions to drugs","volume":"28","author":"Roujeau","year":"1986","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jaci.2010.08.007_bib21","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1001\/archderm.1987.01660330082014","article-title":"Genetic susceptibility to toxic epidermal necrolysis","volume":"123","author":"Roujeau","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2010.08.007_bib22","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.ajo.2008.12.040","article-title":"Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset","volume":"147","author":"Araki","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jaci.2010.08.007_bib23","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.ophtha.2006.10.029","article-title":"New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome","volume":"114","author":"Sotozono","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jaci.2010.08.007_bib24","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.jaci.2007.07.048","article-title":"Association of IL4R polymorphisms with Stevens-Johnson syndrome","volume":"120","author":"Ueta","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.08.007_bib25","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1167\/iovs.07-1401","article-title":"Association of combined IL-13\/IL-4R signaling pathway gene polymorphism with Stevens-Johnson syndrome accompanied by ocular surface complications","volume":"49","author":"Ueta","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jaci.2010.08.007_bib26","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/bjo.2007.136796","article-title":"Association of Fas Ligand gene polymorphism with Stevens-Johnson syndrome","volume":"92","author":"Ueta","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jaci.2010.08.007_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ajo.2006.09.029","article-title":"Strong association between HLA-A\u22170206 and Stevens-Johnson syndrome in the Japanese","volume":"143","author":"Ueta","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jaci.2010.08.007_bib28","first-page":"550","article-title":"HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese","volume":"14","author":"Ueta","year":"2008","journal-title":"Mol Vis"},{"key":"10.1016\/j.jaci.2010.08.007_bib29","doi-asserted-by":"crossref","first-page":"12838","DOI":"10.1073\/pnas.0906397106","article-title":"Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population","volume":"106","author":"Nakano","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2010.08.007_bib30","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1001\/archderm.138.8.1019","article-title":"Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study","volume":"138","author":"Auquier-Dunant","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2010.08.007_bib31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","article-title":"Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2010.08.007_bib32","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2332\/allergolint.O-07-483","article-title":"Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan from 2000 to 2006","volume":"56","author":"Yamane","year":"2007","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaci.2010.08.007_bib33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/bjo.2007.128322","article-title":"Human conjunctival epithelial cells express functional Toll-like receptor 5","volume":"92","author":"Kojima","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jaci.2010.08.007_bib34","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2005.02.196","article-title":"Triggering of TLR3 by polyI: C in human corneal epithelial cells to induce inflammatory cytokines","volume":"331","author":"Ueta","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2010.08.007_bib35","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaci.2008.09.044","article-title":"Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis","volume":"123","author":"Ueta","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.08.007_bib36","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1100\/tsw.2007.182","article-title":"Prostaglandin receptor signaling in disease","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Sci World J"},{"key":"10.1016\/j.jaci.2010.08.007_bib37","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00109-009-0500-1","article-title":"Prostanoids and inflammation: a new concept arising from receptor knockout mice","volume":"87","author":"Narumiya","year":"2009","journal-title":"J Mol Med"},{"key":"10.1016\/j.jaci.2010.08.007_bib38","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jaci.2009.04.029","article-title":"Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity","volume":"124","author":"Honda","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.08.007_bib39","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1999.79.4.1193","article-title":"Prostanoid receptors: structures, properties, and functions","volume":"79","author":"Narumiya","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jaci.2010.08.007_bib40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2008.08.019","article-title":"Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies","volume":"83","author":"Yamaguchi-Kabata","year":"2008","journal-title":"Am J Hum Genet"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910011929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910011929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:23:51Z","timestamp":1758788631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674910011929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0091674910011929"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2010.08.007","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2010.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}