{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:19:57Z","timestamp":1789589997529,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.jaci.2010.10.050","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T04:14:04Z","timestamp":1296533644000},"page":"390-397.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies"],"prefix":"10.1016","volume":"127","author":[{"given":"Adnan","family":"Custovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Rothers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Woodcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaos C.","family":"Nicolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Hankinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Halonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando D.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2010.10.050_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys","volume":"368","author":"Asher","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2010.10.050_bib2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1378\/chest.102.2.654","article-title":"A population-based study of bronchial asthma in adult twin pairs","volume":"102","author":"Duffy","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2010.10.050_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.gene.6364284","article-title":"Asthma genetics 2006: the long and winding road to gene discovery","volume":"7","author":"Ober","year":"2006","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2010.10.050_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1398-9995.2006.01031.x","article-title":"Day-care attendance and increased risk for respiratory and allergic symptoms in preschool age","volume":"61","author":"Hagerhed-Engman","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2010.10.050_bib5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJM200008243430803","article-title":"Siblings, day-care attendance, and the risk of asthma and wheezing during childhood","volume":"343","author":"Ball","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib6","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1164\/rccm.200209-1063OC","article-title":"Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years","volume":"167","author":"Celedon","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/bmj.322.7283.390","article-title":"Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study","volume":"322","author":"Illi","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2010.10.050_bib8","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/aje\/153.7.653","article-title":"Family size, day-care attendance, and breastfeeding in relation to the incidence of childhood asthma","volume":"153","author":"Infante-Rivard","year":"2001","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaci.2010.10.050_bib9","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jaci.2008.06.033","article-title":"Day-care attendance, position in sibship, and early childhood wheezing: a population-based birth cohort study","volume":"122","author":"Nicolaou","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib10","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.1542\/peds.2004-2785","article-title":"Early respiratory infections, asthma, and allergy: 10-year follow-up of the Oslo Birth Cohort","volume":"116","author":"Nafstad","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2010.10.050_bib11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1289\/ehp.6662","article-title":"Early-life environmental risk factors for asthma: findings from the Children's Health Study","volume":"112","author":"Salam","year":"2004","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jaci.2010.10.050_bib12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1067\/mai.2003.172","article-title":"Hygiene hypothesis: fact or fiction?","volume":"111","author":"Liu","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib13","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJMe078119","article-title":"Of attraction and rejection\u2013asthma and the microbial world","volume":"357","author":"von Mutius","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib14","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(01)06252-3","article-title":"Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey","volume":"358","author":"Riedler","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2010.10.050_bib15","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJMoa020057","article-title":"Environmental exposure to endotoxin and its relation to asthma in school-age children","volume":"347","author":"Braun-Fahrlander","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2003.12.374","article-title":"Toll-like receptor 2 as a major gene for asthma in children of European farmers","volume":"113","author":"Eder","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1164\/rccm.200810-1533OC","article-title":"CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults","volume":"179","author":"Smit","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2222.2004.01839.x","article-title":"An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population","volume":"34","author":"Noguchi","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2010.10.050_bib19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ajic.2004.11.007","article-title":"Infectious disease in pediatric out-of-home child care","volume":"33","author":"Brady","year":"2005","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.jaci.2010.10.050_bib20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/clinids\/8.4.524","article-title":"Acute respiratory infections in day care","volume":"8","author":"Denny","year":"1986","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.jaci.2010.10.050_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2214.2004.00411.x","article-title":"Child day care risks of common infectious diseases revisited","volume":"30","author":"Lu","year":"2004","journal-title":"Child Care Health Dev"},{"issue":"suppl\u00a015","key":"10.1016\/j.jaci.2010.10.050_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1034\/j.1399-3038.13.s.15.3.x","article-title":"The National Asthma Campaign Manchester Asthma and Allergy Study","volume":"13","author":"Custovic","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib23","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/ppul.20019","article-title":"Tobacco smoke exposure, wheeze, and atopy","volume":"37","author":"Murray","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2010.10.050_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaci.2009.10.008","article-title":"Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics","volume":"125","author":"Nicolaou","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1164\/rccm.200406-695OC","article-title":"Wheeze phenotypes and lung function in preschool children","volume":"171","author":"Lowe","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib26","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1001\/archpedi.158.10.996","article-title":"Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens","volume":"158","author":"Lowe","year":"2004","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib27","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jaci.2007.07.036","article-title":"Influence of early day-care exposure on total IgE levels through age 3 years","volume":"120","author":"Rothers","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jaci.2007.05.050","article-title":"Low IFN-gamma production in the first year of life as a predictor of wheeze during childhood","volume":"120","author":"Stern","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib29","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/j.1365-2222.2010.03539.x","article-title":"Relation of early antibiotic use to childhood asthma: confounding by indication?","volume":"40","author":"Su","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2010.10.050_bib30","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1164\/ajrccm.156.6.9612066","article-title":"Cold air challenge at age 6 and subsequent incidence of asthma: a longitudinal study","volume":"156","author":"Lombardi","year":"1997","journal-title":"Am J\u00a0Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0140-6736(01)05406-X","article-title":"Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial","volume":"358","author":"Custovic","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2010.10.050_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1399-3038.1997.tb00164.x","article-title":"Endotoxin exposure and symptoms in asthmatic children","volume":"8","author":"Rizzo","year":"1997","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib33","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1136\/adc.2003.038539","article-title":"Reported versus\u00a0confirmed wheeze and lung function in early life","volume":"89","author":"Lowe","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2010.10.050_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00125817-200203000-00002","article-title":"A comprehensive review of genetic association studies","volume":"4","author":"Hirschhorn","year":"2002","journal-title":"Genet Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib35","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0140-6736(02)09641-1","article-title":"Expression of CD14 and Toll-like receptor 2 in farmers' and non-farmers' children","volume":"360","author":"Lauener","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2010.10.050_bib36","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib37","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jaci.2006.03.030","article-title":"The Faustian bargain of genetic association studies: bigger might not be better, or at least it might not be good enough","volume":"117","author":"Vercelli","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2010.10.050_bib38","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1371\/journal.pmed.0050131","article-title":"Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure","volume":"5","author":"Bisgaard","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.jaci.2010.10.050_bib39","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1534\/genetics.106.060004","article-title":"Genetic and environmental effects on complex traits in mice","volume":"174","author":"Valdar","year":"2006","journal-title":"Genetics"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910018312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674910018312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:26:03Z","timestamp":1758788763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674910018312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0091674910018312"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2010.10.050","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2010.10.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}