{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:09:58Z","timestamp":1792127398977,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.jaci.2011.01.057","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T23:09:29Z","timestamp":1299539369000},"page":"990-997.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":129,"title":["Mechanisms underlying differential food allergy response to heated egg"],"prefix":"10.1016","volume":"127","author":[{"given":"Gustavo","family":"Martos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Lopez-Exposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Bencharitiwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Cecilia","family":"Berin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nowak-W\u0119grzyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2011.01.057_bib1","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1021\/jf053178j","article-title":"Effects of heat treatment and pectin addition on beta-lactoglobulin allergenicity","volume":"54","author":"Peyron","year":"2006","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jaci.2011.01.057_bib2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2222.1987.tb02039.x","article-title":"Effect of homogenization and pasteurization on the allergenicity of bovine milk analysed by a murine anaphylactic shock model","volume":"17","author":"Poulsen","year":"1987","journal-title":"Clin Allergy"},{"key":"10.1016\/j.jaci.2011.01.057_bib3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0091-6749(92)90135-O","article-title":"Fish hypersensitivity, II: clinical relevance of altered fish allergenicity caused by various preparation methods","volume":"90","author":"Bernhisel-Broadbent","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/07315724.1995.10718503","article-title":"Meat allergy, II\u2013effects of food processing and enzymatic digestion on the allergenicity of bovine and ovine meats","volume":"14","author":"Fiocchi","year":"1995","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.jaci.2011.01.057_bib5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/07315724.1997.10718700","article-title":"Effect of technological treatments on digestibility and allergenicity of meat-based baby foods","volume":"16","author":"Restani","year":"1997","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.jaci.2011.01.057_bib6","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.fct.2006.12.016","article-title":"Evaluating the effect of food processing on the potential human allergenicity of novel proteins: international workshop report","volume":"45","author":"Thomas","year":"2007","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jaci.2011.01.057_bib7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jaci.2006.10.039","article-title":"Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy","volume":"119","author":"Untersmayr","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jaci.2004.10.022","article-title":"Molecular properties of food allergens","volume":"115","author":"Breiteneder","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1398-9995.2006.01134.x","article-title":"Tolerance to cooked egg in an egg allergic population","volume":"61","author":"Des Roches","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2011.01.057_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jaci.2008.05.032","article-title":"Consumption of heat-treated egg by children allergic or sensitized to egg can affect the natural course of egg allergy: hypothesis-generating observations","volume":"122","author":"Konstantinou","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0091-6749(97)70220-3","article-title":"Allergenic activity of heated and ovomucoid-depleted egg white","volume":"100","author":"Urisu","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jaci.2008.09.007","article-title":"Immunologic changes in children with egg allergy ingesting extensively heated egg","volume":"122","author":"Lemon-Mule","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib13","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.4049\/jimmunol.159.4.2026","article-title":"Allergenic properties of ovomucoid in man","volume":"159","author":"Cooke","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib14","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1398-9995.2008.01673.x","article-title":"Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer\u2019s patches","volume":"63","author":"Roth-Walter","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2011.01.057_bib15","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jaci.2009.01.070","article-title":"Mediator release assay for assessment of biological potency of German cockroach allergen extracts","volume":"123","author":"Nowak-Wegrzyn","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib16","first-page":"76","article-title":"Mediator release assays based on human and murine IgE: potential and limitations in allergen standardization","volume":"94","author":"Hoffmann","year":"2003","journal-title":"Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A\u00a0M"},{"key":"10.1016\/j.jaci.2011.01.057_bib17","first-page":"250","article-title":"Allergy to heated and processed foods","volume":"91","author":"Vieths","year":"1997","journal-title":"Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A\u00a0M"},{"key":"10.1016\/j.jaci.2011.01.057_bib18","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.4049\/jimmunol.131.4.1949","article-title":"Dissociation of IgE from receptors on human basophils, I: enhanced passive sensitization for histamine release","volume":"131","author":"Pruzansky","year":"1983","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jaci.2008.06.016","article-title":"Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy","volume":"122","author":"Ando","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib20","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1271\/bbb.68.2490","article-title":"Recognition of native and\/or thermally induced denatured forms of the major food allergen, ovomucoid, by human IgE and mouse monoclonal IgG antibodies","volume":"68","author":"Hirose","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jaci.2011.01.057_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1067\/mai.2001.114241","article-title":"Will genetically modified foods be allergenic?","volume":"107","author":"Taylor","year":"2001","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2011.01.057_bib22","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1080\/10408399609527763","article-title":"Assessment of the allergenic potential of foods derived from genetically engineered crop plants","volume":"36","author":"Metcalfe","year":"1996","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jaci.2011.01.057_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.pharmtox.42.082401.130208","article-title":"Protein allergenicity assessment of foods produced through agricultural biotechnology","volume":"42","author":"Taylor","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jaci.2011.01.057_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0924-2244(93)90059-J","article-title":"Molten globule state of food proteins","volume":"4","author":"Hirose","year":"1993","journal-title":"Trends Food Sci Technol"},{"key":"10.1016\/j.jaci.2011.01.057_bib25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/oxfordjournals.jbchem.a122286","article-title":"Conformational changes in ovalbumin at acid pH","volume":"103","author":"Koseki","year":"1988","journal-title":"J Biochem"},{"key":"10.1016\/j.jaci.2011.01.057_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/prot.340060202","article-title":"The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure","volume":"6","author":"Kuwajima","year":"1989","journal-title":"Proteins"},{"key":"10.1016\/j.jaci.2011.01.057_bib27","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1021\/jf904538w","article-title":"Egg white ovalbumin digestion mimicking physiological conditions","volume":"58","author":"Martos","year":"2010","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jaci.2011.01.057_bib28","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1248\/bpb.26.969","article-title":"Comparative study of in vitro digestibility of food proteins and effect of preheating on the digestion","volume":"26","author":"Takagi","year":"2003","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jaci.2011.01.057_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-1-4899-2626-5_21","article-title":"Studies of food allergens: soybean and egg proteins","volume":"289","author":"Djurtoft","year":"1991","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jaci.2011.01.057_bib30","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nbt1096-1269","article-title":"Stability of food allergens to digestion in vitro","volume":"14","author":"Astwood","year":"1996","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jaci.2011.01.057_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1742-4658.2004.04472.x","article-title":"Stability of the major allergen Brazil nut 2S albumin (Ber e 1) to physiologically relevant in vitro gastrointestinal digestion","volume":"272","author":"Moreno","year":"2005","journal-title":"FEBS J"},{"key":"10.1016\/j.jaci.2011.01.057_bib32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbapap.2005.07.022","article-title":"Thermostability and in vitro digestibility of a purified major allergen 2S albumin (Ses i 1) from white sesame seeds (Sesamum indicum L.)","volume":"1752","author":"Moreno","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jaci.2011.01.057_bib33","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jaci.2006.04.057","article-title":"Effect of in vitro gastric and duodenal digestion on the allergenicity of grape lipid transfer protein","volume":"118","author":"Vassilopoulou","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib34","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.jaci.2004.06.017","article-title":"Strong allergenicity of Pru av 3, the lipid transfer protein from cherry, is related to high stability against thermal processing and digestion","volume":"114","author":"Scheurer","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib35","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.4049\/jimmunol.164.11.5844","article-title":"Structure of the major peanut allergen Ara h 1 may protect IgE-binding epitopes from degradation","volume":"164","author":"Maleki","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib36","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1365-2222.2006.02565.x","article-title":"Gastro-duodenal digestion products of the major peanut allergen Ara h 1 retain an allergenic potential","volume":"36","author":"Eiwegger","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2011.01.057_bib37","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1021\/jf072907n","article-title":"Determination of pepsin-susceptible and pepsin-resistant epitopes in native and heat-treated peanut allergen Ara h 1","volume":"56","author":"van Boxtel","year":"2008","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jaci.2011.01.057_bib38","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/mnfr.201000011","article-title":"Digestion of peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6: a comparative in vitro study and partial characterization of digestion-resistant peptides","volume":"54","author":"Koppelman","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jaci.2011.01.057_bib39","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1399-3038.2007.00678.x","article-title":"The effect of digestion and pH on the allergenicity of kiwifruit proteins","volume":"19","author":"Lucas","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib40","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0091-6749(03)01719-6","article-title":"Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB\/c mice","volume":"112","author":"Untersmayr","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib41","series-title":"Antigen Presentation by Intestinal Epithelial Cells","first-page":"1","article-title":"Antigen handling by intestinal epithelial cells","author":"Heyman","year":"1996"},{"key":"10.1016\/j.jaci.2011.01.057_bib42","first-page":"G558","article-title":"Horseradish peroxidase transport across adult rabbit jejunum in vitro","volume":"242","author":"Heyman","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jaci.2011.01.057_bib43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1749-6632.2002.tb04136.x","article-title":"Hypothesis: the protein body effect and other aspects of food matrix effects","volume":"964","author":"Teuber","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2011.01.057_bib44","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1271\/bbb.64.198","article-title":"Ovomucoid rendered insoluble by heating with wheat gluten but not with milk casein","volume":"64","author":"Kato","year":"2000","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jaci.2011.01.057_bib45","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-3083.1998.00432.x","article-title":"Heat denaturation of egg-white proteins abrogates the induction of oral tolerance of specific Th2 immune responses in mice","volume":"48","author":"Peng","year":"1998","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaci.2011.01.057_bib46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jaci.2009.08.013","article-title":"Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A\u00a0type I and II","volume":"125","author":"Ilchmann","year":"2010","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491100251X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491100251X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:30:05Z","timestamp":1758789005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167491100251X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S009167491100251X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2011.01.057","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms underlying differential food allergy response to heated egg","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2011.01.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}