{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:44:19Z","timestamp":1790394259010,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.jaci.2011.03.039","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T05:54:32Z","timestamp":1307685272000},"page":"1612-1621.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects"],"prefix":"10.1016","volume":"127","author":[{"given":"Hiroyuki","family":"Fujita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Chalubinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Rhyner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Indermitte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Ferstl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Treis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Akkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"O\u2019Mahony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcbeccel","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2011.03.039_bib1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1056\/NEJMra0804579","article-title":"Asthma","volume":"360","author":"Fanta","year":"2009","journal-title":"N Engl J Med"},{"issue":"suppl","key":"10.1016\/j.jaci.2011.03.039_bib2","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.jaci.2009.10.047","article-title":"Asthma: clinical expression and molecular mechanisms","volume":"125","author":"Lemanske","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jaci.2009.09.047","article-title":"The irreversible component of persistent asthma","volume":"124","author":"Pascual","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1172\/JCI8124","article-title":"Airway remodeling in asthma","volume":"104","author":"Elias","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2011.03.039_bib5","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jaci.2005.06.030","article-title":"Airway smooth muscle: a modulator of airway remodeling in asthma","volume":"116","author":"Lazaar","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2011.03.039_bib6","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jaci.2004.04.039","article-title":"Proliferative aspects of airway smooth muscle","volume":"114","author":"Hirst","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaci.2008.01.031","article-title":"Immunologic and inflammatory mechanisms that drive asthma progression to remodeling","volume":"121","author":"Broide","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.trsl.2009.06.008","article-title":"Targeting the airway smooth muscle for asthma treatment","volume":"154","author":"Camoretti-Mercado","year":"2009","journal-title":"Transl Res"},{"key":"10.1016\/j.jaci.2011.03.039_bib9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jaci.2009.02.030","article-title":"Mechanisms and treatment of allergic disease in the big picture of regulatory T cells","volume":"123","author":"Akdis","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jaci.2010.11.030","article-title":"Mechanisms of allergen-specific immunotherapy","volume":"127","author":"Akdis","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib11","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jaci.2007.12.1171","article-title":"Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases","volume":"121","author":"Akkoc","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/35067088","article-title":"Multifunctional strands in tight junctions","volume":"2","author":"Tsukita","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2011.03.039_bib13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ceb.2005.08.003","article-title":"Mammalian tight junctions in the regulation of epithelial differentiation and proliferation","volume":"17","author":"Matter","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jaci.2011.03.039_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","article-title":"Intestinal barrier function: molecular regulation and disease pathogenesis","volume":"124","author":"Groschwitz","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib15","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1158\/0008-5472.CAN-05-2782","article-title":"Claudin proteins in human cancer: promising new targets for diagnosis and therapy","volume":"65","author":"Morin","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaci.2011.03.039_bib16","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1038\/sj.onc.1210155","article-title":"Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility","volume":"26","author":"Leotlela","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.jaci.2011.03.039_bib17","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/sj.jid.5700882","article-title":"Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1","volume":"127","author":"Zimmerli","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2011.03.039_bib18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaci.2009.04.019","article-title":"Dual nature of T cell-epithelium interaction in chronic rhinosinusitis","volume":"124","author":"Basinski","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jaci.2009.05.015","article-title":"Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema","volume":"124","author":"Zeller","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib20","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1084\/jem.20090596","article-title":"Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells","volume":"206","author":"Klunker","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2011.03.039_bib21","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jaci.2010.01.016","article-title":"IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis","volume":"125","author":"Meyer","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jaci.2007.04.004","article-title":"IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1","volume":"120","author":"Taylor","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/cvr\/cvp117","article-title":"The tight junction protein ZO-2 mediates proliferation of vascular smooth muscle cells via regulation of Stat1","volume":"83","author":"Kusch","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jaci.2011.03.039_bib24","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1172\/JCI24543","article-title":"Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer","volume":"115","author":"Dhawan","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2011.03.039_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1074\/jbc.M109.054189","article-title":"Claudin-1 acts through c-Abl-protein kinase Cdelta (PKCdelta) signaling and has a causal role in the acquisition of invasive capacity in human liver cells","volume":"285","author":"Yoon","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2011.03.039_bib26","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/labinvest.2008.78","article-title":"Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation","volume":"88","author":"Weber","year":"2008","journal-title":"Lab Invest"},{"key":"10.1016\/j.jaci.2011.03.039_bib27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2353\/ajpath.2010.090548","article-title":"Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation","volume":"176","author":"Tang","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2011.03.039_bib28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1749-6632.2009.04984.x","article-title":"Cytokines and glucocorticoid receptor signaling. Relevance to major depression","volume":"1179","author":"Pace","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2011.03.039_bib29","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1067\/mai.2001.115626","article-title":"Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma","volume":"107","author":"Hoshino","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1067\/mai.2001.111928","article-title":"Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis","volume":"107","author":"Hoshino","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib31","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1067\/mai.2001.115628","article-title":"Vascular endothelial growth factor in patients with acute asthma","volume":"107","author":"Lee","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib32","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nm1105","article-title":"Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung","volume":"10","author":"Lee","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2011.03.039_bib33","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking","volume":"168","author":"Dufour","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib34","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.4049\/jimmunol.171.2.1078","volume":"171","author":"Klunker","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib35","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1084\/jem.184.3.981","article-title":"Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases","volume":"184","author":"Arenberg","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2011.03.039_bib36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/bbrc.1995.1626","article-title":"Interferon gamma-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis","volume":"210","author":"Strieter","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2011.03.039_bib37","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.4049\/jimmunol.163.10.5686","article-title":"IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis","volume":"163","author":"Keane","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib38","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/CIRCRESAHA.109.199471","article-title":"Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction","volume":"105","author":"Bujak","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.jaci.2011.03.039_bib39","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jaci.2004.10.036","article-title":"Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa","volume":"115","author":"Fukakusa","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib40","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.4049\/jimmunol.168.10.5278","article-title":"IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma","volume":"168","author":"Medoff","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2011.03.039_bib41","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jaci.2010.11.050","article-title":"Interleukins from 1 to 37 and interferon-gamma: receptors, functions and roles in diseases","volume":"127","author":"Akdis","year":"2011","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674911005690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674911005690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:29:43Z","timestamp":1758788983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674911005690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0091674911005690"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2011.03.039","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2011.03.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}