{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:00:01Z","timestamp":1791349201115,"version":"4.3.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.jaci.2011.04.032","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T09:14:22Z","timestamp":1311412462000},"page":"626-634.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in\u00a0vitro through a transient receptor potential melastatin 8 (TRPM8)\u2013mediated mechanism"],"prefix":"10.1016","volume":"128","author":[{"given":"MinChao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor P.","family":"Kolosov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliy M.","family":"Perelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2011.04.032_bib1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0091-6749(83)90479-7","article-title":"Asthma in childhood","volume":"72","author":"Ellis","year":"1983","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2011.04.032_bib2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1034\/j.1399-3003.1999.13d25.x","article-title":"Effect of temperature on lung function and symptoms in chronic obstructive pulmonary disease","volume":"13","author":"Donaldson","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2011.04.032_bib3","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1183\/09031936.98.12040825","article-title":"Inhalation of cold air increases the number of inflammatory cells in the lungs in healthy subjects","volume":"12","author":"Larsson","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2011.04.032_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2011.04.032_bib5","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2011.04.032_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/jn.00843.2002","article-title":"TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat","volume":"90","author":"Nealen","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jaci.2011.04.032_bib7","first-page":"3760","article-title":"Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins [J]","volume":"61","author":"Tsavaler","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaci.2011.04.032_bib8","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1100\/tsw.2010.149","article-title":"TRP channels in human prostate","volume":"10","author":"Van Haute","year":"2010","journal-title":"Sci World J"},{"key":"10.1016\/j.jaci.2011.04.032_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000264627","article-title":"Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24","volume":"77","author":"Li","year":"2009","journal-title":"Oncology"},{"key":"10.1016\/j.jaci.2011.04.032_bib10","doi-asserted-by":"crossref","first-page":"L1267","DOI":"10.1152\/ajplung.00515.2005","article-title":"Functional expression of transient receptor potential melastatin- (TRPM) and vanilloid-related (TRPV) channels in pulmonary arterial and aortic smooth muscle","volume":"290","author":"Yang","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"179","key":"10.1016\/j.jaci.2011.04.032_bib11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-3-540-34891-7_20","article-title":"TRPM8","author":"Voets","year":"2007","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jaci.2011.04.032_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.2006.123059","article-title":"Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors","volume":"581","author":"M\u00e4lki\u00e4","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.jaci.2011.04.032_bib13","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1074\/jbc.M605213200","article-title":"TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and golgi","volume":"282","author":"Mahieu","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2011.04.032_bib14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1165\/rcmb.2007-0440OC","article-title":"Human lung epithelial cells express a functional cold-sensing TRPM8 variant","volume":"39","author":"Sabnis","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2011.04.032_bib15","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nn1451","article-title":"PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain","volume":"8","author":"Roh\u00e1cs","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jaci.2011.04.032_bib16","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1074\/jbc.M807270200","article-title":"Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate","volume":"284","author":"Daniels","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2011.04.032_bib17","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1523\/JNEUROSCI.3632-04.2005","article-title":"Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4, 5-bisphosphate","volume":"25","author":"Liu","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.jaci.2011.04.032_bib18","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1152\/physrev.2000.80.4.1291","article-title":"Structure, function, and control of phosphoinositide-specific phospholipase C","volume":"80","author":"Rebecchi","year":"2000","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jaci.2011.04.032_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.arr.2009.05.002","article-title":"The ER and ageing II: calcium homeostasis","volume":"8","author":"Puzianowska-Kuznicka","year":"2009","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jaci.2011.04.032_bib20","doi-asserted-by":"crossref","first-page":"40982","DOI":"10.1074\/jbc.M105614200","article-title":"MARCKs protein is a key molecule regulating mucin secretion by human airway epithelial cells in\u00a0vitro","volume":"276","author":"Li","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2011.04.032_bib21","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.2353\/ajpath.2007.070318","article-title":"Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein","volume":"171","author":"Park","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2011.04.032_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3620001","article-title":"Cross-talk unfolded: MARCKS protein","volume":"362","author":"Arbuzova","year":"2002","journal-title":"Biochem J"},{"key":"10.1016\/j.jaci.2011.04.032_bib23","doi-asserted-by":"crossref","first-page":"L194","DOI":"10.1152\/ajplung.00072.2008","article-title":"Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by\u00a0cold temperatures","volume":"295","author":"Sabnis","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2011.04.032_bib24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1744-8069-4-22","article-title":"TRPM8 mechanism of autonomic nerve response to cold in respiratory airway","volume":"4","author":"Xing","year":"2008","journal-title":"Mol Pain"},{"key":"10.1016\/j.jaci.2011.04.032_bib25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1165\/rcmb.2006-0035SF","article-title":"Regulation of mucin genes in chronic inflammatory airway diseases","volume":"34","author":"Voynow","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2011.04.032_bib26","doi-asserted-by":"crossref","first-page":"23424","DOI":"10.1074\/jbc.271.38.23424","article-title":"Myristoylation-dependent and electrostatic interactions exert independent effects on the membrane association of the myristoylated alanine-rich protein kinase C substrate protein in intact cells","volume":"271","author":"Swierczynski","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2011.04.032_bib27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/thx.2004.025692","article-title":"Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells","volume":"60","author":"Mata","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2011.04.032_bib28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature05910","article-title":"The menthol receptor TRPM8 is the principal detector of environmental cold","volume":"448","author":"Bautista","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2011.04.032_bib29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","article-title":"Attenuated cold sensitivity in TRPM8 null mice","volume":"54","author":"Colburn","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.jaci.2011.04.032_bib30","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nchembio862","article-title":"TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli","volume":"3","author":"Voets","year":"2007","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jaci.2011.04.032_bib31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nn1665","article-title":"High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol","volume":"9","author":"Bandell","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jaci.2011.04.032_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2005.12.005","article-title":"Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8","volume":"397","author":"Abe","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jaci.2011.04.032_bib33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ncb781","article-title":"The TRPM7 channel is inactivated by PIP(2) hydrolysis","volume":"4","author":"Runnels","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2011.04.032_bib34","doi-asserted-by":"crossref","first-page":"15160","DOI":"10.1073\/pnas.2334159100","article-title":"Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5","volume":"100","author":"Liu","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2011.04.032_bib35","doi-asserted-by":"crossref","first-page":"39185","DOI":"10.1074\/jbc.M506965200","article-title":"Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization","volume":"280","author":"Zhang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2011.04.032_bib36","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/ar.1092360124","article-title":"Localization of cholecystokinin-like peptide in neuroendocrine cells of mammalian lungs: a light and electron microscopic immunohistochemical study","volume":"236","author":"Wang","year":"1993","journal-title":"Anat Rec"},{"key":"10.1016\/j.jaci.2011.04.032_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0143-4179(92)90518-2","article-title":"Gastrin releasing peptide (GRP) binding sites in human bronchi","volume":"21","author":"Baraniuk","year":"1992","journal-title":"Neuropeptides"},{"key":"10.1016\/j.jaci.2011.04.032_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1447-073x.2005.00103.x","article-title":"Structure of the respiratory tract of the red-bellied newt Cynops pyrrhogaster, with reference to serotonin-positive neuroepithelial endocrine cells","volume":"80","author":"Naruse","year":"2005","journal-title":"Anat Sci Int"},{"key":"10.1016\/j.jaci.2011.04.032_bib39","first-page":"1134","article-title":"Physiology of airway mucus secretion and pathophysiology of hypersecretion","volume":"52","author":"Rogers","year":"2007","journal-title":"Respir Care"},{"key":"10.1016\/j.jaci.2011.04.032_bib40","first-page":"71","article-title":"Effect of proinflammatory cytokines on the human MUC5AC promoter activity in\u00a0vitro and in\u00a0vivo","volume":"1","author":"Wang","year":"2007","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jaci.2011.04.032_bib41","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.4049\/jimmunol.0803022","article-title":"IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells","volume":"183","author":"Bautista","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2011.04.032_bib42","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1164\/rccm.200811-1744OC","article-title":"Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells","volume":"179","author":"Zhao","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2011.04.032_bib43","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/jcb.22330","article-title":"Upregulation of MUC5AC gene expression by IL-4 through CREB in human airway epithelial cells","volume":"108","author":"Kim","year":"2009","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jaci.2011.04.032_bib44","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"176","author":"Rabe","year":"2007","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674911006695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674911006695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:32:08Z","timestamp":1758789128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674911006695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0091674911006695"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2011.04.032","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in\u00a0vitro through a transient receptor potential melastatin 8 (TRPM8)\u2013mediated mechanism","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2011.04.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}