{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:15:08Z","timestamp":1790936108891,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.jaci.2011.09.047","type":"journal-article","created":{"date-parts":[[2011,12,10]],"date-time":"2011-12-10T05:02:14Z","timestamp":1323493334000},"page":"770-777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia"],"prefix":"10.1016","volume":"129","author":[{"given":"Romain","family":"Micol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Kayal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar","family":"Mahlaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Beaut\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Brosselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Dudoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Obenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Barlogis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Aladjidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Kebaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Dulieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Monpoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00eble","family":"Nov\u00e9-Josserand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Pellier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lambotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Masseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Galanaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Oksenhendler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Dominique","family":"Tabone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Teira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Coignard-Biehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lanternier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Join-Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Mouillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Theodorou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Lecron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Alexandra","family":"Alyanakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Blanche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Debr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lecuit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Durandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2011.09.047_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.immunol.021908.132649","article-title":"Primary B cell immunodeficiencies: comparisons and contrasts","volume":"27","author":"Conley","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/00222615-18-1-1","article-title":"The pathogenicity of Haemophilus influenzae","volume":"18","author":"Turk","year":"1984","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jaci.2011.09.047_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/INF.0b013e318184dba2","article-title":"Nontypeable Haemophilus influenzae as a pathogen in children","volume":"28","author":"Murphy","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2011.09.047_bib4","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1164\/ajrccm.164.11.2104093","article-title":"Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis","volume":"164","author":"Bandi","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2011.09.047_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.tim.2007.06.004","article-title":"Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior","volume":"15","author":"Erwin","year":"2007","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jaci.2011.09.047_bib6","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1086\/518283","article-title":"Characterization of invasive Haemophilus influenzae disease in Manitoba, Canada, 2000-2006: invasive disease due to non-type b strains","volume":"44","author":"Tsang","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaci.2011.09.047_bib7","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1164\/ajrccm.159.4.9807067","article-title":"Viruses and bacteria in bronchial samples from patients with primary hypogammaglobulinemia","volume":"159","author":"Kainulainen","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2011.09.047_bib8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archotol.133.6.597","article-title":"Bacteria and viruses in maxillary sinuses of patients with primary hypogammaglobulinemia","volume":"133","author":"Kainulainen","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2011.09.047_bib9","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1080\/00365540110076769","article-title":"Impact of IgG replacement therapy and antibiotic treatment on the colonization of non-encapsulated Haemophilus influenzae in the nasopharynx in patients with hypogammaglobulinaemia","volume":"33","author":"Lindberg","year":"2001","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.jaci.2011.09.047_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.clim.2005.11.002","article-title":"The health status and quality of life of adults with X-linked agammaglobulinemia","volume":"118","author":"Howard","year":"2006","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib11","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1086\/587669","article-title":"Infections in 252 patients with common variable immunodeficiency","volume":"46","author":"Oksenhendler","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaci.2011.09.047_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/clim.2002.5241","article-title":"Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: an Italian multicenter study","volume":"104","author":"Plebani","year":"2002","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/thx.2005.047332","article-title":"Longitudinal pulmonary function of childhood bronchiectasis and comparison with cystic fibrosis","volume":"61","author":"Twiss","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2011.09.047_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/01.mcp.0000208451.50231.8f","article-title":"Role of nontypeable Haemophilus influenzae in exacerbations and progression of chronic obstructive pulmonary disease","volume":"12","author":"Eldika","year":"2006","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jaci.2011.09.047_bib15","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.rmed.2007.03.009","article-title":"Microbiologic follow-up study in adult bronchiectasis","volume":"101","author":"King","year":"2007","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2011.09.047_bib16","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2249.2005.02793.x","article-title":"Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method","volume":"140","author":"Ferry","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-3476(99)70246-5","article-title":"Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: a retrospective survey of 31 patients","volume":"134","author":"Quartier","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2011.09.047_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10875-008-9227-y","article-title":"Clinical and molecular analysis of 49 patients with X-linked agammaglobulinemia from a single center in Argentina","volume":"29","author":"Basile","year":"2009","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib19","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1056\/NEJMoa0900082","article-title":"STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity","volume":"360","author":"Picard","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2011.09.047_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0065-2776(06)94009-7","article-title":"Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies","volume":"94C","author":"Durandy","year":"2007","journal-title":"Adv Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0950268800067017","article-title":"Haemophilus influenzae subtyping by SDS-PAGE of whole-cell polypeptides","volume":"99","author":"Paterson","year":"1987","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jaci.2011.09.047_bib22","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)00079-9","article-title":"Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)","volume":"102","author":"Revy","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2011.09.047_bib23","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1365-2249.2008.03697.x","article-title":"Systemic humoral immunity to non-typeable Haemophilus influenzae","volume":"153","author":"King","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib24","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1086\/344233","article-title":"St Geme JW 3rd. Immunization with Haemophilus influenzae Hap adhesin protects against nasopharyngeal colonization in experimental mice","volume":"186","author":"Cutter","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2011.09.047_bib25","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1699-0463.1996.tb04933.x","article-title":"Local and systemic antibody levels against protein D of Haemophilus influenzae following immunization and infection in rats","volume":"104","author":"Akkoyunlu","year":"1996","journal-title":"APMIS"},{"key":"10.1016\/j.jaci.2011.09.047_bib26","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1128\/iai.64.12.5187-5192.1996","article-title":"Immunization with outer membrane protein P6 from nontypeable Haemophilus influenzae induces bactericidal antibody and affords protection in the chinchilla model of otitis media","volume":"64","author":"DeMaria","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2011.09.047_bib27","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1128\/iai.59.9.3191-3198.1991","article-title":"The e (P4) outer membrane protein of Haemophilus influenzae: biologic activity of anti-e serum and cloning and sequencing of the structural gene","volume":"59","author":"Green","year":"1991","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2011.09.047_bib28","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S1097-2765(00)80298-1","article-title":"The Haemophilus influenzae Hap serine protease promotes adherence and microcolony formation, potentiated by a soluble host protein","volume":"2","author":"Hendrixson","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2011.09.047_bib29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2958.1994.tb01283.x","article-title":"A Haemophilus influenzae IgA protease-like protein promotes intimate interaction with human epithelial cells","volume":"14","author":"St Geme","year":"1994","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jaci.2011.09.047_bib30","doi-asserted-by":"crossref","first-page":"26010","DOI":"10.1074\/jbc.M801819200","article-title":"The Haemophilus influenzae HMW1 adhesin is a glycoprotein with an unusual N-linked carbohydrate modification","volume":"283","author":"Gross","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2011.09.047_bib31","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1128\/CVI.00221-06","article-title":"Antibodies specific for the high-molecular-weight adhesion proteins of nontypeable Haemophilus influenzae are opsonophagocytic for both homologous and heterologous strains","volume":"13","author":"Winter","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1574-6976.1999.tb00393.x","article-title":"Molecular determinants of the pathogenesis of disease due to non-typable Haemophilus influenzae","volume":"23","author":"Rao","year":"1999","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.jaci.2011.09.047_bib33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.0105-2896.2005.00283.x","article-title":"Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties","volume":"206","author":"Brandtzaeg","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2011.09.047_bib34","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1126\/science.1077336","article-title":"Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora","volume":"298","author":"Fagarasan","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jaci.2011.09.047_bib35","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1748","article-title":"Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils","volume":"10","author":"Chen","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2011.09.047_bib36","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1084\/jem.20021457","article-title":"Unmutated immunoglobulin M can protect mice from death by influenza virus infection","volume":"197","author":"Harada","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2011.09.047_bib37","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nri2849","article-title":"The importance of natural IgM: scavenger, protector and regulator","volume":"10","author":"Ehrenstein","year":"2010","journal-title":"Nat Rev Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674911016599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674911016599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:32:38Z","timestamp":1758789158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674911016599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0091674911016599"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2011.09.047","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2011.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}