{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:01:31Z","timestamp":1758816091606,"version":"3.44.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES11170","ES10957","AI61772","AI60515","T32AI07469"],"award-info":[{"award-number":["ES11170","ES10957","AI61772","AI60515","T32AI07469"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000204","name":"U.S. Department of Housing and Urban Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000204","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.jaci.2012.01.051","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T15:59:49Z","timestamp":1330963189000},"page":"1529-1537.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["House dust bioactivities predict skin prick test reactivity for children with high risk of allergy"],"prefix":"10.1016","volume":"129","author":[{"given":"Haejin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Tse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina","family":"Reponen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"LeMasters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zana","family":"Lummus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A.","family":"Horner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.01.051_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000227761","article-title":"Regulation of aeroallergen immunity by the innate immune system: laboratory evidence for a new paradigm","volume":"2","author":"Horner","year":"2010","journal-title":"J Innate Immun"},{"issue":"suppl","key":"10.1016\/j.jaci.2012.01.051_bib2","doi-asserted-by":"crossref","first-page":"4S","DOI":"10.1378\/chest.130.1_suppl.4S","article-title":"The global burden of asthma","volume":"130","author":"Braman","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.01.051_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00130832-200304000-00006","article-title":"Early origins of allergic disease: a review of processes and influences during early immune development","volume":"3","author":"Prescott","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/eji.200838367","article-title":"Imprinted DC mediate the immune-educating effect of early-life microbial exposure","volume":"39","author":"Jiao","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000235398","article-title":"Epidemiology of the relationship between exposure to indoor allergens and asthma","volume":"94","author":"Platts-Mills","year":"1991","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1067\/mai.2001.111146","article-title":"House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program","volume":"107","author":"Huss","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00281-003-0149-8","article-title":"Mechanisms of tolerance to inhalant allergens: the relevance of a modified Th2 response to allergens from domestic animals","volume":"25","author":"Platts-Mills","year":"2004","journal-title":"Springer Semin Immunopathol"},{"key":"10.1016\/j.jaci.2012.01.051_bib8","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jaci.2005.03.006","article-title":"Advances in environmental and occupational diseases 2004","volume":"115","author":"Frew","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00130832-200312000-00015","article-title":"Does exposure to dogs and cats in the first year of life influence the development of allergic sensitization?","volume":"3","author":"Ownby","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jpeds.2010.07.026","article-title":"Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort","volume":"158","author":"Epstein","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2012.01.051_bib11","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1067\/mai.2001.115245","article-title":"Metropolitan home living conditions associated with indoor endotoxin levels","volume":"107","author":"Gereda","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib12","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJMoa020057","article-title":"Environmental exposure to endotoxin and its relation to asthma in school-age children","volume":"347","author":"Braun-Fahrlander","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.01.051_bib13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jaci.2006.08.008","article-title":"Influence of dog ownership and high endotoxin on wheezing and atopy during infancy","volume":"118","author":"Campo","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib14","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/S0140-6736(00)02239-X","article-title":"Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma","volume":"355","author":"Gereda","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2012.01.051_bib15","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1084\/jem.20102229","article-title":"Invariant NKT cells are required for airway inflammation induced by environmental antigens","volume":"208","author":"Wingender","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2012.01.051_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jaci.2005.03.015","article-title":"House dust extracts elicit Toll-like receptor-dependent dendritic cell responses","volume":"116","author":"Boasen","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib17","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0091-6749(03)01863-3","article-title":"Bacterial DNA in house and farm barn dust","volume":"112","author":"Roy","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib18","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jaci.2004.01.783","article-title":"Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health","volume":"113","author":"van Strien","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib19","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jaci.2006.03.025","article-title":"House dust extracts have both Th2 adjuvant and tolerogenic activities","volume":"117","author":"Ng","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1165\/rcmb.2010-0001OC","article-title":"Regulatory T cells contribute to allergen tolerance induced by daily airway immunostimulant exposures","volume":"44","author":"Lee","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2012.01.051_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jaci.2005.05.014","article-title":"Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic","volume":"116","author":"Ryan","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jpeds.2006.06.035","article-title":"High prevalence of aeroallergen sensitization among infants of atopic parents","volume":"149","author":"LeMasters","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2012.01.051_bib23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/15428119791012199","article-title":"Environmental endotoxin measurement: interference and sources of variation in the Limulus assay of house dust","volume":"58","author":"Milton","year":"1997","journal-title":"Am Ind Hyg Assoc J"},{"key":"10.1016\/j.jaci.2012.01.051_bib24","first-page":"133","article-title":"Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease","volume":"12","author":"Medvedev","year":"2006","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.jaci.2012.01.051_bib25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.it.2009.07.009","article-title":"Endotoxin tolerance: new mechanisms, molecules and clinical significance","volume":"30","author":"Biswas","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib26","doi-asserted-by":"crossref","first-page":"E33","DOI":"10.1542\/peds.108.2.e33","article-title":"Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study","volume":"108","author":"Arshad","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2012.01.051_bib27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1399-3038.2006.00453.x","article-title":"Patterns of sensitization in infants and its relation to atopic dermatitis","volume":"17","author":"Johnke","year":"2006","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2222.2003.01562.x","article-title":"Endotoxin levels in Estonian and Swedish house dust and atopy in infancy","volume":"33","author":"Bottcher","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.01.051_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2007.03.037","article-title":"Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood","volume":"120","author":"Celedon","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib30","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1183\/09031936.00118806","article-title":"Bacteria and mould components in house dust and children\u2019s allergic sensitisation","volume":"29","author":"Gehring","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.01.051_bib31","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1001\/jama.284.13.1647","article-title":"Levels of environmental endotoxin and prevalence of atopic disease","volume":"284","author":"Gereda","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2012.01.051_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00281-007-0098-8","article-title":"Defining a role for ambient TLR ligand exposures in the genesis and prevention of allergic diseases","volume":"30","author":"Tse","year":"2008","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jaci.2012.01.051_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/ACI.0b013e32833653d7","article-title":"Gene-environment interactions in asthma and allergy: the end of the beginning?","volume":"10","author":"Vercelli","year":"2010","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2008.10.046","article-title":"Gene-environment interactions in asthma","volume":"123","author":"von Mutius","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib35","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1365-2222.2003.01760.x","article-title":"Risk factors for atopic dermatitis in infancy: are we closer to effective primary atopy prevention?","volume":"33","author":"Heine","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.01.051_bib36","first-page":"5","article-title":"Genetic and environmental risk factors for the development of atopy and related diseases","volume":"59","author":"Perfetti","year":"2003","journal-title":"Monaldi Arch Chest Dis"},{"key":"10.1016\/j.jaci.2012.01.051_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/01.all.0000162308.89857.6c","article-title":"Risk factors for asthma and atopy","volume":"5","author":"Arruda","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.01.051_bib38","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1398-9995.2006.01009.x","article-title":"The PASTURE project: EU support for the improvement of knowledge about risk factors and preventive factors for atopy in Europe","volume":"61","author":"von Mutius","year":"2006","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912001741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912001741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:32:34Z","timestamp":1758789154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912001741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0091674912001741"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.01.051","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"House dust bioactivities predict skin prick test reactivity for children with high risk of allergy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.01.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}