{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:04:30Z","timestamp":1791032670572,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.jaci.2012.02.004","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T06:23:59Z","timestamp":1332915839000},"page":"1076-1084","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Morphologic and immunohistochemical characterization of\u00a0granulomas in the nucleotide oligomerization domain 2\u2013related disorders Blau syndrome and Crohn disease"],"prefix":"10.1016","volume":"129","author":[{"given":"Carl E.I.","family":"Janssen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"De Hertogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy M.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Bader Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Cimaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Harjacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Quartier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ten Cate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Thomee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeer J.","family":"Desmet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Roskams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine H.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.02.004_bib1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0022-3476(85)80394-2","article-title":"Familial granulomatous arthritis, iritis and rash","volume":"107","author":"Blau","year":"1985","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2012.02.004_bib2","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1002\/art.22122","article-title":"Pediatric granulomatous arthritis: an international registry","volume":"54","author":"Ros\u00e9","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2012.02.004_bib3","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1002\/art.22966","article-title":"NOD2 gene associated pediatric granulomatous arthritis: clonical diversity, novel and recurrent mutations, and evidence of clinical improvement with interleukin-1blockade in a Spanish Cohort","volume":"56","author":"Arostegui","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2012.02.004_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng720","article-title":"CARD15 mutations in Blau syndrome","volume":"29","author":"Miceli-Richard","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2012.02.004_bib5","first-page":"373","article-title":"Blau syndrome mutation of CARD15\/NOD2 in sporadic early onset granulomatous arthritis","volume":"32","author":"Ros\u00e9","year":"2005","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaci.2012.02.004_bib6","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1182\/blood-2004-07-2972","article-title":"Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome","volume":"105","author":"Kanazawa","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2012.02.004_bib7","first-page":"3612","article-title":"Blau syndrome\u2014a chronic granulomatous, genetic disease","volume":"168","author":"Milman","year":"2006","journal-title":"Ugesker Laeger"},{"key":"10.1016\/j.jaci.2012.02.004_bib8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s00535-009-0191-y","article-title":"The role of infection in the aetiology of inflammatory bowel disease","volume":"45","author":"Hansen","year":"2010","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jaci.2012.02.004_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ibd.21349","article-title":"Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends","volume":"17","author":"Benchimol","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jaci.2012.02.004_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1365-2796.2009.02137.x","article-title":"NOD2\/CARD15 genotype and common gastrointestinal diseases in 43,600 individuals","volume":"267","author":"Yazdanyar","year":"2010","journal-title":"J Intern Med"},{"key":"10.1016\/j.jaci.2012.02.004_bib11","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/ibd.20213","article-title":"Pediatric inflammatory bowel disease: clinical and molecular genetics","volume":"13","author":"Biank","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jaci.2012.02.004_bib12","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1073\/pnas.0530276100","article-title":"Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases","volume":"100","author":"Chamaillard","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2012.02.004_bib13","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.suc.2007.03.003","article-title":"Extra-intestinal manifestations of Crohn\u2019s disease","volume":"87","author":"Ephgrave","year":"2007","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.jaci.2012.02.004_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/gut.2004.042572","article-title":"Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn\u2019s disease","volume":"54","author":"Pierik","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jaci.2012.02.004_bib15","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1056\/NEJM199704243361706","article-title":"Sarcoidosis","volume":"336","author":"Newman","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.02.004_bib16","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1056\/NEJMra071714","article-title":"Sarcoidosis","volume":"357","author":"Iannuzzi","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.02.004_bib17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1046\/j.1365-2567.2000.00025.x","article-title":"Inflammatory cytokine production by immunological and foreign body multinucleated giant cells","volume":"100","author":"Hernandez-Pando","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2012.02.004_bib18","first-page":"1050","article-title":"Histologic, ultrastructural, and immunocytochemical features of the granulomas seen in a child with the syndrome of familial granulomatous arthritis, uveitis, and rash","volume":"117","author":"de Chadar\u00e9vian","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jaci.2012.02.004_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00129039-200206000-00013","article-title":"Evaluation of Th-1 and Th-2 immune responses in the skin lesions of patients with Blau syndrome","volume":"10","author":"Ewida","year":"2002","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.jaci.2012.02.004_bib20","first-page":"747","article-title":"Current concepts of the pathogenesis of sarcoidosis","volume":"135","author":"Thomas","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2012.02.004_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2141.1956.tb06700.x","article-title":"Biological interaction between lymphocytes and other cells","volume":"2","author":"Humble","year":"1956","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2012.02.004_bib22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/dc.21421","article-title":"Neutrophil phagocytosis by tumor cells\u2014a cytological study","volume":"39","author":"Singhal","year":"2010","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.jaci.2012.02.004_bib23","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/dc.20904","article-title":"Diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) by fine needle aspiration cytology","volume":"36","author":"Kumar","year":"2008","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.jaci.2012.02.004_bib24","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/PAS.0b013e3181d5ddf8","article-title":"Development of disseminated histiocytic sarcoma in a patient with autoimmune lymphoproliferative syndrome and associated Rosai-Dorfman disease","volume":"34","author":"Venkataraman","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaci.2012.02.004_bib25","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/cr.2008.64","article-title":"Emperipolesis, entosis and beyond: dance with fate","volume":"7","author":"Xia","year":"2008","journal-title":"Cell Res"},{"key":"10.1016\/j.jaci.2012.02.004_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.coi.2010.12.003","article-title":"What is new with Nods?","volume":"23","author":"Magalhaes","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2012.02.004_bib27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1053\/gast.2002.35393","article-title":"Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn\u2019s disease","volume":"123","author":"Abreu","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2012.02.004_bib28","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/BF00713433","article-title":"The cellular composition of granulomas in mesenteric lymph nodes from patients with Crohn\u2019s disease","volume":"409","author":"Geboes","year":"1986","journal-title":"Virchows Arch A\u00a0Pathol Anat Histopathol"},{"key":"10.1016\/j.jaci.2012.02.004_bib29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1056\/NEJM198108203050804","article-title":"Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity","volume":"305","author":"Hunninghake","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.02.004_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1164\/ajrccm\/143.1.53","article-title":"Increased levels of serum interferon-gamma in pulmonary sarcoidosis and relationship with response to corticosteroid therapy","volume":"143","author":"Prior","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2012.02.004_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2249.1995.tb03713.x","article-title":"Presence of mRNA for interferon-gamma (IFN-gamma) in blood mononuclear cells is associated with an active stage I sarcoidosis","volume":"100","author":"Swider","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2012.02.004_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1165\/ajrcmb.16.2.9032124","article-title":"Th1\/Th2 cell distribution in pulmonary sarcoidosis","volume":"16","author":"B\u00e4umer","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"suppl\u00a08","key":"10.1016\/j.jaci.2012.02.004_bib33","first-page":"73","article-title":"CD4+ intestinal mucosal lymphocytes in the pathogenesis of Crohn\u2019s disease","volume":"30","author":"Watanabe","year":"1995","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jaci.2012.02.004_bib34","first-page":"252","article-title":"Differential diagnosis of granulomatous diseases\u2014epithelioid cell granuloma in the intestine and liver in Crohn disease?","volume":"32","author":"Gallwitz","year":"1994","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.jaci.2012.02.004_bib35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/labinvest.3700189","article-title":"Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn\u2019s disease: a pivotal site of Th1-shifted immune response?","volume":"85","author":"Oki","year":"2005","journal-title":"Lab Invest"},{"key":"10.1016\/j.jaci.2012.02.004_bib36","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1111\/j.1572-0241.1999.01220.x","article-title":"Type 1 T-helper cell predominance in granulomas of Crohn\u2019s disease","volume":"94","author":"Kakazu","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jaci.2012.02.004_bib37","doi-asserted-by":"crossref","first-page":"14739","DOI":"10.1073\/pnas.1003363107","article-title":"Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum","volume":"107","author":"Biswas","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2012.02.004_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.smim.2008.01.001","article-title":"The central role of the Th17 lineage in regulating the inflammatory\/autoimmune axis","volume":"19","author":"Weaver","year":"2007","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jaci.2012.02.004_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2012.02.004_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2009.05.140","article-title":"TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23","volume":"386","author":"Morishima","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2012.02.004_bib41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nm1551","article-title":"A brief history of T(H)17, the first major revision in the T(H)1\/T(H)2 hypothesis of T cell-mediated tissue damage","volume":"13","author":"Steinman","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2012.02.004_bib42","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.4049\/jimmunol.180.11.7112","article-title":"Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6","volume":"180","author":"Zheng","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.02.004_bib43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.clim.2009.09.013","article-title":"Essential and synergistic roles of IL1 and IL6 in human Th17 differentiation directed by TLR ligand-activated dendritic cells","volume":"134","author":"Benwell","year":"2010","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2012.02.004_bib44","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.immuni.2007.08.013","article-title":"Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells","volume":"27","author":"van Beelen","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2012.02.004_bib45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03240.x","article-title":"Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease","volume":"119","author":"Onishi","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2012.02.004_bib46","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.4049\/jimmunol.0903332","article-title":"Essential role of IL-17\u00aa in the formation of a mycobacterial infection-induced granuloma in the lung","volume":"184","author":"Yoshida","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.02.004_bib47","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.3748\/wjg.v16.i14.1753","article-title":"NOD2\/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn\u2019s disease","volume":"16","author":"Gazouli","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jaci.2012.02.004_bib48","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ibd.20339","article-title":"Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn\u2019s disease and analysis of the IL17F p.His161Arg polymorphism in IBD","volume":"14","author":"Seiderer","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jaci.2012.02.004_bib49","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1053\/j.gastro.2011.02.016","article-title":"Proinflammatory cytokines in the pathognesis of inflammatory bowel disease","volume":"149","author":"Strober","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2012.02.004_bib50","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1586\/eci.10.46","article-title":"Use of immunomodulators and biologic therapies in children with inflammatory bowel disease","volume":"6","author":"Bousvaros","year":"2010","journal-title":"Expert Rev Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912002655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912002655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:31:25Z","timestamp":1758789085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912002655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0091674912002655"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.02.004","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphologic and immunohistochemical characterization of\u00a0granulomas in the nucleotide oligomerization domain 2\u2013related disorders Blau syndrome and Crohn disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}