{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:48:42Z","timestamp":1772120922582,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jaci.2012.04.045","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T08:46:44Z","timestamp":1340009204000},"page":"354-361.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants"],"prefix":"10.1016","volume":"130","author":[{"given":"Bo L.K.","family":"Chawes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Porntiva","family":"Poorisrisak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian L.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Bisgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.04.045_bib1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","article-title":"Rhinovirus illnesses during infancy predict subsequent childhood wheezing","volume":"116","author":"Lemanske","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.04.045_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib4","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2012.04.045_bib5","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1164\/rccm.200904-0567ED","article-title":"Causal links between RSV infection and asthma: no clear answers to an old question","volume":"179","author":"Kuehni","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1164\/rccm.200603-435PP","article-title":"Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation","volume":"175","author":"Singh","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ppul.20069","article-title":"Familial susceptibility to severe respiratory infection in early life","volume":"38","author":"Goetghebuer","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2012.04.045_bib8","doi-asserted-by":"crossref","first-page":"e1360","DOI":"10.1542\/peds.2006-0907","article-title":"Atopic disposition, wheezing, and subsequent respiratory syncytial virus hospitalization in Danish children younger than 18 months: a nested case-control study","volume":"118","author":"Stensballe","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2012.04.045_bib9","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201110-1922OC","article-title":"Interaction between asthma and lung function growth in early life","author":"Bisgaard","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1378\/chest.07-1328","article-title":"Feasibility of repetitive lung function measurements by raised volume rapid thoracoabdominal compression during methacholine challenge in young infants","volume":"133","author":"Loland","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.04.045_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1081-1206(10)61398-1","article-title":"The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study","volume":"93","author":"Bisgaard","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2012.04.045_bib12","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1056\/NEJMoa054692","article-title":"Intermittent inhaled corticosteroids in infants with episodic wheezing","volume":"354","author":"Bisgaard","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib13","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJMoa052632","article-title":"Childhood asthma after bacterial colonization of the airway in neonates","volume":"357","author":"Bisgaard","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib14","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1164\/rccm.200408-1141ST","article-title":"ATS\/ERS statement: raised volume forced expirations in infants: guidelines for current practice","volume":"172","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1378\/chest.129.3.669","article-title":"Sensitivity of bronchial responsiveness measurements in young infants","volume":"129","author":"Loland","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.04.045_bib16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jaci.2008.11.036","article-title":"Prenatal determinants of neonatal lung function in high-risk newborns","volume":"123","author":"Bisgaard","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.04.045_bib17","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1136\/bmj.39374.600081.AD","article-title":"Acute bronchiolitis","volume":"335","author":"Bush","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2012.04.045_bib18","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1542\/peds.2006-2223","article-title":"Diagnosis and management of bronchiolitis","volume":"118","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2012.04.045_bib19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0140-6736(06)69077-6","volume":"368","author":"Smyth","year":"2006","journal-title":"Bronchiolitis. Lancet"},{"key":"10.1016\/j.jaci.2012.04.045_bib20","doi-asserted-by":"crossref","first-page":"c4978","DOI":"10.1136\/bmj.c4978","article-title":"Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study","volume":"341","author":"Bisgaard","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2012.04.045_bib21","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaci.2011.02.007","article-title":"Endotyping early childhood asthma by quantitative symptom assessment","volume":"127","author":"Bisgaard","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.04.045_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1398-9995.2005.00936.x","article-title":"ImmunoCAP Phadiatop Infant\u2014a new blood test for detecting IgE sensitisation in children at 2 years of age","volume":"61","author":"Ballardini","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.04.045_bib23","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.0905-6157.2003.00079.x","article-title":"Quantification of IgE antibodies simplifies the classification of allergic diseases in 4-year-old children. A\u00a0report from the prospective birth cohort study\u2014BAMSE","volume":"14","author":"Wickman","year":"2003","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.04.045_bib24","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archderm.142.5.561","article-title":"Development of atopic dermatitis during the first 3 years of life: the Copenhagen prospective study on asthma in childhood cohort study in high-risk children","volume":"142","author":"Halkjaer","year":"2006","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2012.04.045_bib25","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1056\/NEJMoa052885","article-title":"Reduced lung function at birth and the risk of asthma at 10 years of age","volume":"355","author":"Haland","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib26","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM198810273191702","article-title":"Diminished lung function as a predisposing factor for wheezing respiratory illness in infants","volume":"319","author":"Martinez","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib27","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/thorax.57.5.388","article-title":"Lung function at one month of age as a risk factor for infant respiratory symptoms in a high risk population","volume":"57","author":"Murray","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2012.04.045_bib28","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1164\/ajrccm\/147.4.811","article-title":"Lung function, pre- and post-natal smoke exposure, and wheezing in the first year of life","volume":"147","author":"Tager","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2012.04.045_bib29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1183\/09031936.00.15115100","article-title":"The association between early life lung function and wheezing during the first 2 yrs of life","volume":"15","author":"Young","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.04.045_bib30","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaci.2010.05.026","article-title":"The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children","volume":"126","author":"Simoes","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.04.045_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/adc.72.1.16","article-title":"Lung function, airway responsiveness, and respiratory symptoms before and after bronchiolitis","volume":"72","author":"Young","year":"1995","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2012.04.045_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2431-4-25","article-title":"Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993-2000: a population-based retrospective study","volume":"4","author":"Fjaerli","year":"2004","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jaci.2012.04.045_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1017\/S095026880200729X","article-title":"Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995-March 1998","volume":"129","author":"Muller-Pebody","year":"2002","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jaci.2012.04.045_bib34","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/j.1651-2227.2003.tb00502.x","article-title":"Respiratory syncytial virus infection\u2014risk factors for hospital admission: a case-control study","volume":"92","author":"Nielsen","year":"2003","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jaci.2012.04.045_bib35","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.282.15.1440","article-title":"Bronchiolitis-associated hospitalizations among US children, 1980-1996","volume":"282","author":"Shay","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2012.04.045_bib36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/rccm.200809-1436OC","article-title":"Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood","volume":"179","author":"Bisgaard","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib37","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1378\/chest.129.3.669","article-title":"Sensitivity of bronchial responsiveness measurements in young infants","volume":"129","author":"Loland","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.04.045_bib38","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jaci.2008.11.036","article-title":"Prenatal determinants of neonatal lung function in high-risk newborns","volume":"123","author":"Bisgaard","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.04.045_bib39","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1081-1206(10)61398-1","article-title":"The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study","volume":"93","author":"Bisgaard","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2012.04.045_bib40","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2012.04.045_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/rccm.200809-1436OC","article-title":"Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood","volume":"179","author":"Bisgaard","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.04.045_bib42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1056\/NEJMoa0901867","article-title":"Variants of DENND1B associated with asthma in children","volume":"362","author":"Sleiman","year":"2010","journal-title":"N Engl J Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912007786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912007786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:35:42Z","timestamp":1758789342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912007786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0091674912007786"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.04.045","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717962700.793464652","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.04.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}