{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:43:10Z","timestamp":1790379790465,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jaci.2012.05.049","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T04:17:35Z","timestamp":1343449055000},"page":"523-530.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study"],"prefix":"10.1016","volume":"130","author":[{"given":"Georg","family":"Loss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sondhja","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Wohlgensinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo","family":"Frei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Roduit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Genuneit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Pekkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjut","family":"Roponen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija-Riitta","family":"Hirvonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Dalphin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Dalphin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Riedler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"von Mutius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Braun-Fahrl\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Lauener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.05.049_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1398-9995.2010.02489.x","article-title":"Genetic variations in toll-like receptor pathway genes influence asthma and atopy","volume":"66","author":"Tesse","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.cell.2006.02.019","article-title":"Translating innate immunity into immunological memory: implications for vaccine development","volume":"124","author":"Pulendran","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2012.05.049_bib3","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.jaci.2007.01.037","article-title":"Not all farming environments protect against the development of asthma and wheeze in children","volume":"119","author":"Ege","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0140-6736(02)09641-1","article-title":"Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children","volume":"360","author":"Lauener","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2012.05.049_bib5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMoa1007302","article-title":"Exposure to environmental microorganisms and childhood asthma","volume":"364","author":"Ege","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.05.049_bib6","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jaci.2011.07.048","article-title":"The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study","volume":"128","author":"Loss","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib7","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.jaci.2007.07.034","article-title":"A polymorphism in CD14 modifies the effect of farm milk consumption on allergic diseases and CD14 gene expression","volume":"120","author":"Bieli","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaci.2003.12.583","article-title":"The Toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype","volume":"113","author":"Ahmad-Nejad","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2003.12.374","article-title":"Toll-like receptor 2 as a major gene for asthma in children of European farmers","volume":"113","author":"Eder","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1398-9995.2007.01358.x","article-title":"Putative association of a TLR9 promoter polymorphism with atopic eczema","volume":"62","author":"Novak","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaci.2010.10.010","article-title":"Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis","volume":"127","author":"Roduit","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jaci.2005.12.1307","article-title":"Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children","volume":"117","author":"Ege","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jaci.2010.09.041","article-title":"Gene-environment interaction for childhood asthma and exposure to farming in Central Europe","volume":"127","author":"Ege","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1399-3038.2008.00718.x","article-title":"The importance of early complementary feeding in the development of oral tolerance: concerns and controversies","volume":"19","author":"Prescott","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib15","article-title":"The development of atopic dermatitis according to age of onset and the association with early life exposures","author":"Roduit","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1399-3038.2011.01230.x","article-title":"Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study","volume":"23","author":"Belderbos","year":"2012","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1398-9995.2006.01009.x","article-title":"The PASTURE project: EU support for the improvement of knowledge about risk factors and preventive factors for atopy in Europe","volume":"61","author":"von Mutius","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib18","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1398-9995.2005.00939.x","article-title":"Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle\u2014the PARSIFAL study","volume":"61","author":"Alfven","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1034\/j.1399-3038.2002.02081.x","article-title":"Domestic aeroallergen levels in Barcelona and Menorca (Spain)","volume":"13","author":"Basagana","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib20","first-page":"1","article-title":"Epidemiology standardization project","volume":"118","author":"Ferris","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2012.05.049_bib21","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(01)06252-3","article-title":"Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey","volume":"358","author":"Riedler","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2012.05.049_bib22","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/j.1398-9995.2008.01744.x","article-title":"Gene expression measurements in the context of epidemiological studies","volume":"63","author":"Bieli","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/meth.2001.1261","article-title":"An overview of real-time quantitative PCR: applications to quantify cytokine gene expression","volume":"25","author":"Giulietti","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jaci.2012.05.049_bib24","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/MOP.0b013e3283325e3a","article-title":"Neonatal innate immunity in allergy development","volume":"21","author":"Belderbos","year":"2009","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jaci.2012.05.049_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.prrv.2007.11.004","article-title":"Effects of early cigarette smoke exposure on early immune development and respiratory disease","volume":"9","author":"Prescott","year":"2008","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.jaci.2012.05.049_bib26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature07548","article-title":"Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein","volume":"457","author":"Trompette","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2012.05.049_bib27","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ni.1919","article-title":"Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel","volume":"11","author":"Schmidt","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1365-2222.2007.02715.x","article-title":"Unpasteurized milk: health or hazard?","volume":"37","author":"Perkin","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/ACI.0b013e32832b3f1d","article-title":"The long-term health effects of neonatal microbial flora","volume":"9","author":"Conroy","year":"2009","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib30","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nri2871","article-title":"Farm living: effects on childhood asthma and allergy","volume":"10","author":"von Mutius","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib31","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1398-9995.2005.00939.x","article-title":"Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle\u2014the PARSIFAL study","volume":"61","author":"Alfven","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1034\/j.1399-3038.2002.02081.x","article-title":"Domestic aeroallergen levels in Barcelona and Menorca (Spain)","volume":"13","author":"Basagana","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.05.049_bib33","first-page":"1","article-title":"Epidemiology standardization project","volume":"118","author":"Ferris","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2012.05.049_bib34","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(01)06252-3","article-title":"Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey","volume":"358","author":"Riedler","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2012.05.049_bib35","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/j.1398-9995.2008.01744.x","article-title":"Gene expression measurements in the context of epidemiological studies","volume":"63","author":"Bieli","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00019606-200603000-00009","article-title":"Validation of the 2(-Delta Delta Ct) calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts","volume":"15","author":"Arocho","year":"2006","journal-title":"Diagn Mol Pathol"},{"key":"10.1016\/j.jaci.2012.05.049_bib37","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jaci.2012.05.049_bib38","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1398-9995.2006.01009.x","article-title":"The PASTURE project: EU support for the improvement of knowledge about risk factors and preventive factors for atopy in Europe","volume":"61","author":"von Mutius","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.049_bib39","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1164\/rccm.200410-1312OC","article-title":"G-protein-coupled receptor polymorphisms are associated with asthma in a large German population","volume":"171","author":"Kormann","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.05.049_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jaci.2008.04.039","article-title":"Toll-like receptor heterodimer variants protect from childhood asthma","volume":"122","author":"Kormann","year":"2008","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912009542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912009542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:33:16Z","timestamp":1758789196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912009542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0091674912009542"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.05.049","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717955659.793460662","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.05.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}