{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:39:31Z","timestamp":1791110371412,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jaci.2012.05.054","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T04:12:29Z","timestamp":1343448749000},"page":"389-396.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Risk factors and characteristics of respiratory and allergic phenotypes in early childhood"],"prefix":"10.1016","volume":"130","author":[{"given":"Marie","family":"Herr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Just","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Nikasinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Foucault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Le Marec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Giordanella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Momas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.05.054_bib1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1136\/thx.2006.070169","article-title":"Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"62","author":"Pearce","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2012.05.054_bib2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1398-9995.2010.02534.x","article-title":"MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine","volume":"66","author":"Bousquet","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib3","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/thx.52.11.946","article-title":"Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood","volume":"52","author":"Stein","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2012.05.054_bib4","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1164\/ajrccm.162.4.9912111","article-title":"A clinical index to define risk of asthma in young children with recurrent wheezing","volume":"162","author":"Castro-Rodriguez","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.05.054_bib5","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jaci.2010.06.032","article-title":"The Asthma Predictive Index: a very useful tool for predicting asthma in young children","volume":"126","author":"Castro-Rodriguez","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib6","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1183\/09031936.00002108","article-title":"Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach","volume":"32","author":"Brand","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.05.054_bib7","unstructured":"Global strategy for the diagnosis and management of asthma in children 5 years and younger. Global Initiative for Asthma Report. Update 2009. Available at: www.ginasthma.com. Accessed 2009."},{"key":"10.1016\/j.jaci.2012.05.054_bib8","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1183\/09031936.00153507","article-title":"Distinguishing phenotypes of childhood wheeze and cough using latent class analysis","volume":"31","author":"Spycher","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.05.054_bib9","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1164\/rccm.200709-1419OC","article-title":"Dimensions of respiratory symptoms in preschool children: population-based birth cohort study","volume":"177","author":"Smith","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.05.054_bib10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/thx.2007.093187","article-title":"Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood","volume":"63","author":"Henderson","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2012.05.054_bib11","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.200907-1101OC","article-title":"Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study","volume":"181","author":"Simpson","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.05.054_bib12","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jaci.2010.11.015","article-title":"Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health\/National Heart, Lung, and Blood Institute Severe Asthma Research Program","volume":"127","author":"Fitzpatrick","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1513\/pats.200808-092RM","article-title":"The origins of asthma and chronic obstructive pulmonary disease in early life","volume":"6","author":"Martinez","year":"2009","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaci.2012.05.054_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10654-007-9109-2","article-title":"The Paris prospective birth cohort study: which design and who participates?","volume":"22","author":"Clarisse","year":"2007","journal-title":"Eur J Epidemiol"},{"issue":"suppl\u00a04","key":"10.1016\/j.jaci.2012.05.054_bib15","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1542\/peds.2007-2329C","article-title":"Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report","volume":"120","author":"Barlow","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2012.05.054_bib16","unstructured":"The WHO child growth standards. Available at: http:\/\/www.who.int\/childgrowth\/standards\/en\/. Accessed 2011."},{"key":"10.1016\/j.jaci.2012.05.054_bib17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1365-2222.2008.02966.x","article-title":"Lack of eosinophilia can predict remission in wheezy infants?","volume":"38","author":"Just","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1399-3038.2005.00364.x","article-title":"The predictive value of early life total immunoglobulin E measurement in identifying atopic children in a population-based birth cohort study","volume":"17","author":"Perkin","year":"2006","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1398-9995.2008.01779.x","article-title":"The allergic sensitization in infants with atopic eczema from different countries","volume":"64","author":"de Benedictis","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib20","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1111\/j.1365-2222.2008.03138.x","article-title":"Antibiotic use in the first year of life and risk of atopic disease in early childhood","volume":"38","author":"Kusel","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib21","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0091-6749(95)70174-5","article-title":"Peripheral blood eosinophilia in infants at 3 months of age is associated with subsequent development of atopic disease in early childhood","volume":"95","author":"Borres","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1398-9995.1981.tb01584.x","article-title":"Evaluation of laboratory tests in childhood allergy. Total serum IgE, blood eosinophilia and eosinophil and mast cells in nasal mucosa of 178 children aged 3 years","volume":"36","author":"Kajosaari","year":"1981","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib23","first-page":"180","article-title":"Early allergic sensitizations and their relevance to atopic diseases in children aged 6 years: results of the GINI study","volume":"19","author":"Brockow","year":"2009","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jaci.2010.09.022","article-title":"Sex differences in asthma during the first 8 years of life: the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study","volume":"127","author":"Wijga","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib25","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1398-9995.2011.02578.x","article-title":"An explorative study of low levels of allergen-specific IgE and clinical allergy symptoms during early childhood","volume":"66","author":"Soderstrom","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1600-0668.2009.00594.x","article-title":"Assessment and predictor determination of indoor aldehyde levels in Paris newborn babies' homes","volume":"19","author":"Dassonville","year":"2009","journal-title":"Indoor Air"},{"key":"10.1016\/j.jaci.2012.05.054_bib27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0013-9351(03)00039-2","article-title":"Indoor aldehydes: measurement of contamination levels and identification of their determinants in Paris dwellings","volume":"92","author":"Clarisse","year":"2003","journal-title":"Environ Res"},{"key":"10.1016\/j.jaci.2012.05.054_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.envres.2008.04.006","article-title":"Assessment and predictors determination of indoor airborne fungal concentrations in Paris newborn babies' homes","volume":"108","author":"Dassonville","year":"2008","journal-title":"Environ Res"},{"key":"10.1016\/j.jaci.2012.05.054_bib29","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1600-0668.2008.00549.x","article-title":"Indoor airborne endotoxin assessment in homes of Paris newborn babies","volume":"18","author":"Dassonville","year":"2008","journal-title":"Indoor Air"},{"key":"10.1016\/j.jaci.2012.05.054_bib30","series-title":"Applied latent class analysis","author":"Hagenaars","year":"2002"},{"key":"10.1016\/j.jaci.2012.05.054_bib31","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0098-3004(84)90020-7","article-title":"FCM: fuzzy C-means algorithm","volume":"10","author":"Bezdek","year":"1984","journal-title":"Comput Geosci"},{"key":"10.1016\/j.jaci.2012.05.054_bib32","unstructured":"poLCA: polytomous variable latent class analysis, version 1.3.1. Available at: www.service.emory.edu\/...\/poLCA\/poLCA-manual-1-3-1.pdf. Accessed 2010."},{"key":"10.1016\/j.jaci.2012.05.054_bib33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1034\/j.1399-3038.2002.01055.x","article-title":"Environmental risk factors for allergy and socioeconomic status in a birth cohort (BAMSE)","volume":"13","author":"Lannero","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1183\/09031936.00120810","article-title":"Identifying adult asthma phenotypes using a clustering approach","volume":"38","author":"Siroux","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.05.054_bib35","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jaci.2011.02.002","article-title":"Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA","volume":"127","author":"Savenije","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib36","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1365-2222.2009.03348.x","article-title":"Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort","volume":"39","author":"Matricardi","year":"2009","journal-title":"Clin Exp Allergy"},{"issue":"suppl","key":"10.1016\/j.jaci.2012.05.054_bib37","first-page":"S94","article-title":"Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma\u2014summary report 2007","volume":"120","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2222.2011.03933.x","article-title":"Influence of host and environmental factors on wheezing severity in infants: findings from the PARIS birth cohort","volume":"42","author":"Herr","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib39","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1398-9995.2010.02467.x","article-title":"Does allergic rhinitis exist in infancy? Findings from the PARIS birth cohort","volume":"66","author":"Herr","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib40","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1365-2222.2010.03541.x","article-title":"Phenotypes of childhood asthma: are they real?","volume":"40","author":"Spycher","year":"2010","journal-title":"Clin Exp Allergy"},{"issue":"suppl","key":"10.1016\/j.jaci.2012.05.054_bib41","doi-asserted-by":"crossref","first-page":"S497","DOI":"10.1016\/S0091-6749(00)90050-2","article-title":"Viral and bacterial infections in the development and progression of asthma","volume":"105","author":"Gern","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ppul.21161","article-title":"Prevalence and risk factors of wheeze in Dutch infants in their first year of life","volume":"45","author":"Visser","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2012.05.054_bib43","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1164\/ajrccm.155.4.9105079","article-title":"Alternaria as a major allergen for asthma in children raised in a desert environment","volume":"155","author":"Halonen","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.05.054_bib44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2466-5-4","article-title":"Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions","volume":"5","author":"O'Driscoll","year":"2005","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jaci.2012.05.054_bib45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1164\/rccm.200602-231PP","article-title":"Obesity and asthma","volume":"174","author":"Beuther","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.05.054_bib46","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1034\/j.1398-9995.1999.00044.x","article-title":"Different pattern of risk factors for atopic and nonatopic asthma among children\u2014report from the Obstructive Lung Disease in Northern Sweden Study","volume":"54","author":"Ronmark","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.05.054_bib47","first-page":"1059","article-title":"Incidence of asthma diagnosis and self-reported allergy in relation to the school environment\u2014a four-year follow-up study in schoolchildren","volume":"5","author":"Smedje","year":"2001","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jaci.2012.05.054_bib48","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1164\/rccm.200711-1754OC","article-title":"Cluster analysis and clinical asthma phenotypes","volume":"178","author":"Haldar","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.05.054_bib49","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jaci.2010.11.037","article-title":"Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome","volume":"127","author":"Lotvall","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.05.054_bib50","series-title":"Multiple correspondence analysis. Quantitative applications in the social sciences","author":"LeRoux","year":"2010"},{"key":"10.1016\/j.jaci.2012.05.054_bib51","series-title":"Applied latent class analysis","author":"Hagenaars","year":"2002"},{"key":"10.1016\/j.jaci.2012.05.054_bib52","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0098-3004(84)90020-7","article-title":"FCM: Fuzzy C-means algorithm","volume":"10","author":"Bezdek","year":"1984","journal-title":"Comput Geosci"},{"key":"10.1016\/j.jaci.2012.05.054_bib53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1012801612483","article-title":"On clustering validation techniques","volume":"17","author":"Halkidi","year":"2001","journal-title":"J Intelligent Inform Sys"},{"key":"10.1016\/j.jaci.2012.05.054_bib54","unstructured":"poLCA: polytomous variable latent class analysis, version 1.3.1. Available at: www.service.emory.edu\/.\/poLCA\/poLCA-manual-1-3-1.pdf. Accessed 2010."},{"key":"10.1016\/j.jaci.2012.05.054_bib55","unstructured":"Global Strategy for the diagnosis and management of asthma in children 5 years and younger. Global Initiative for Asthma Report. Update 2009. Available at: www.ginasthma.com. Accessed 2009."}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491200961X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491200961X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:36:18Z","timestamp":1758789378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167491200961X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S009167491200961X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.05.054","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors and characteristics of respiratory and allergic phenotypes in early childhood","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.05.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}