{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:59:20Z","timestamp":1790179160557,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.jaci.2012.06.019","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T12:18:37Z","timestamp":1343305117000},"page":"683-691.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Staphylococcus aureus \u03b1-toxin modulates skin host response to viral infection"],"prefix":"10.1016","volume":"130","author":[{"given":"Lianghua","family":"Bin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Eui","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Brauweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Goleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Streib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinduo","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Schlievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald Y.M.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.06.019_bib1","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.06.019_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaci.2009.11.027","article-title":"Recent insights into atopic dermatitis and implications for management of infectious complications","volume":"125","author":"Boguniewicz","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-065X.2011.01027.x","article-title":"Atopic dermatitis: a disease of altered skin barrier and immune dysregulation","volume":"242","author":"Boguniewicz","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2012.06.019_bib4","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMra1011040","article-title":"Filaggrin mutations associated with skin and allergic diseases","volume":"365","author":"Irvine","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.06.019_bib5","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jaci.2009.05.020","article-title":"Phenotype of atopic dermatitis subjects with a history of eczema herpeticum","volume":"124","author":"Beck","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib6","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1056\/NEJM200204253461713","article-title":"The case for voluntary smallpox vaccination","volume":"346","author":"Bicknell","year":"2002","journal-title":"N Engl J Med"},{"issue":"suppl\u00a053","key":"10.1016\/j.jaci.2012.06.019_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-2133.1998.1390s3013.x","article-title":"Staphylococcus aureus colonization in atopic dermatitis and its therapeutic implications","volume":"139","author":"Abeck","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2012.06.019_bib8","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1034\/j.1398-9995.2001.00146.x","article-title":"Bacterial infections and atopic dermatitis","volume":"56","author":"Breuer","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.06.019_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2133.2002.04872.x","article-title":"Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis","volume":"147","author":"Breuer","year":"2002","journal-title":"Br\u00a0J Dermatol"},{"key":"10.1016\/j.jaci.2012.06.019_bib10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000246218","article-title":"Staphylococcus aureus skin colonization in infants with atopic dermatitis","volume":"193","author":"Monti","year":"1996","journal-title":"Dermatology"},{"key":"10.1016\/j.jaci.2012.06.019_bib11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.iac.2010.05.001","article-title":"The infectious aspects of atopic dermatitis","volume":"30","author":"Ong","year":"2010","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaci.2012.06.019_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaci.2009.10.039","article-title":"Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis","volume":"125","author":"Schlievert","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib13","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1073\/pnas.86.22.8941","article-title":"Interaction of Staphylococcus aureus toxin \u201csuperantigens\u201d with human T cells","volume":"86","author":"Choi","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2012.06.019_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-065X.2008.00681.x","article-title":"The bacterial superantigen and superantigen-like proteins","volume":"225","author":"Fraser","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2012.06.019_bib15","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nm.2451","article-title":"A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice","volume":"17","author":"Inoshima","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2012.06.019_bib16","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1126\/science.274.5294.1859","article-title":"Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore","volume":"274","author":"Song","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jaci.2012.06.019_bib17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1271\/bbb.61.565","article-title":"Molecular biology of the pore-forming cytolysins from Staphylococcus aureus, alpha- and gamma-hemolysins and leukocidin","volume":"61","author":"Tomita","year":"1997","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jaci.2012.06.019_bib18","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1128\/iai.57.8.2489-2494.1989","article-title":"Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland","volume":"57","author":"Bramley","year":"1989","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2012.06.019_bib19","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/nm1207-1405","article-title":"Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia","volume":"13","author":"Bubeck Wardenburg","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2012.06.019_bib20","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1128\/IAI.01313-06","article-title":"Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia","volume":"75","author":"Bubeck Wardenburg","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2012.06.019_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.20072208","article-title":"Vaccine protection against Staphylococcus aureus pneumonia","volume":"205","author":"Bubeck Wardenburg","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2012.06.019_bib22","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1086\/656043","article-title":"Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model","volume":"202","author":"Kennedy","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2012.06.019_bib23","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/jid.2011.462","article-title":"Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection","volume":"132","author":"Inoshima","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2012.06.019_bib24","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/IAI.00920-08","article-title":"The H35A mutated alpha-toxin interferes with cytotoxicity of staphylococcal alpha-toxin","volume":"77","author":"Liang","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2012.06.019_bib25","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/jama.1987.03390080043027","article-title":"Toxic shock syndrome. A\u00a0newly recognized complication of influenza and influenzalike illness","volume":"257","author":"MacDonald","year":"1987","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2012.06.019_bib26","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.1021\/bi200435n","article-title":"Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus","volume":"50","author":"Lin","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.jaci.2012.06.019_bib27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jaci.2010.11.013","article-title":"Specificity protein 1 is pivotal in the skin's antiviral response","volume":"127","author":"Bin","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib28","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.4049\/jimmunol.171.6.3262","article-title":"Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes","volume":"171","author":"Nomura","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib29","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.4049\/jimmunol.172.3.1763","article-title":"Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum","volume":"172","author":"Howell","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib30","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1128\/JCM.41.4.1565-1568.2003","article-title":"Rapid detection of herpes simplex virus and varicella-zoster virus infections by real-time PCR","volume":"41","author":"Weidmann","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaci.2012.06.019_bib31","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1073\/pnas.1001815107","article-title":"Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury","volume":"107","author":"Wilke","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2012.06.019_bib32","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jaci.2005.12.1345","article-title":"Cathelicidin deficiency predisposes to eczema herpeticum","volume":"117","author":"Howell","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib33","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.biochi.2007.02.003","article-title":"The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation","volume":"89","author":"Hovanessian","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.jaci.2012.06.019_bib34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1074-7613(00)00014-5","article-title":"Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection","volume":"13","author":"Balachandran","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2012.06.019_bib35","doi-asserted-by":"crossref","first-page":"e1002277","DOI":"10.1371\/journal.ppat.1002277","article-title":"Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1","volume":"7","author":"Di Giovine","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jaci.2012.06.019_bib36","doi-asserted-by":"crossref","first-page":"e17248","DOI":"10.1371\/journal.pone.0017248","article-title":"Drosophila S2 cells are non-permissive for vaccinia virus DNA replication following entry via low pH-dependent endocytosis and early transcription","volume":"6","author":"Bengali","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2012.06.019_bib37","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jaci.2011.02.014","article-title":"Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis","volume":"128","author":"De Benedetto","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib38","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/jid.2011.374","article-title":"Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum","volume":"132","author":"Gao","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2012.06.019_bib39","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jaci.2009.07.034","article-title":"Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum","volume":"124","author":"Gao","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib40","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jaci.2010.03.016","article-title":"Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum","volume":"125","author":"Gao","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib41","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jaci.2011.02.010","article-title":"Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-gamma response","volume":"127","author":"Leung","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.06.019_bib42","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1542\/peds.2008-1336","article-title":"Influenza-associated pediatric mortality in the United States: increase of Staphylococcus aureus coinfection","volume":"122","author":"Finelli","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2012.06.019_bib43","first-page":"612","article-title":"Update on emerging infections: news from the Centers for Disease Control and Prevention. Severe methicillin-resistant Staphylococcus aureus community-acquired pneumonia associated with influenza\u2014Louisiana and Georgia, December 2006-January 2007","volume":"50","author":"Frazee","year":"2007","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jaci.2012.06.019_bib44","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.annemergmed.2008.04.027","article-title":"Staphylococcus aureus community-acquired pneumonia during the 2006 to 2007 influenza season","volume":"53","author":"Kallen","year":"2009","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jaci.2012.06.019_bib45","doi-asserted-by":"crossref","first-page":"26014","DOI":"10.1074\/jbc.M601960200","article-title":"Evidence that clustered phosphocholine head groups serve as sites for binding and assembly of an oligomeric protein pore","volume":"281","author":"Valeva","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2012.06.019_bib46","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1128\/JVI.01345-06","article-title":"Vaccinia virus interactions with the cell membrane studied by new chromatic vesicle and cell sensor assays","volume":"81","author":"Orynbayeva","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2012.06.019_bib47","doi-asserted-by":"crossref","first-page":"e25464","DOI":"10.1371\/journal.pone.0025464","article-title":"Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent","volume":"6","author":"Rahn","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2012.06.019_bib48","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.1128\/JVI.76.14.7203-7208.2002","article-title":"Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry","volume":"76","author":"Yoon","year":"2002","journal-title":"J Virol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912010111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912010111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:34:14Z","timestamp":1758789254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912010111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0091674912010111"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.06.019","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Staphylococcus aureus \u03b1-toxin modulates skin host response to viral infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}