{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:26:28Z","timestamp":1761675988377,"version":"3.44.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jaci.2012.08.030","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T14:11:27Z","timestamp":1350483087000},"page":"849-855.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The innate antiviral response upregulates IL-13 receptor \u03b12 in bronchial fibroblasts"],"prefix":"10.1016","volume":"131","author":[{"given":"Gemma","family":"Campbell-Harding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Sawkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Bedke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T.","family":"Holgate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna E.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison-Lynn","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.08.030_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.immunol.21.120601.141142","article-title":"IL-13 effector functions","volume":"21","author":"Wynn","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.0105-2896.2004.00215.x","article-title":"Interleukin-13 in asthma pathogenesis","volume":"202","author":"Wills-Karp","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2012.08.030_bib3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jaci.2011.06.052","article-title":"Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?","volume":"128","author":"Holgate","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib4","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.4049\/jimmunol.162.10.6233","article-title":"IL-4 induces mucin gene expression and goblet cell metaplasia in\u00a0vitro and in\u00a0vivo","volume":"162","author":"Dabbagh","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib5","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1183\/09031936.96.09050899","article-title":"Endobronchial secretion of interleukin-13 following local allergen challenge in atopic asthma: relationship to interleukin-4 and eosinophil counts","volume":"9","author":"Kroegel","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.08.030_bib6","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.4049\/jimmunol.173.6.4020","article-title":"IL-13 activates a mechanism of tissue fibrosis that is completely TGF\u03b2 independent","volume":"173","author":"Kaviratne","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production","volume":"103","author":"Zhu","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2012.08.030_bib8","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1172\/JCI119311","article-title":"Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc\u03b5RI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells","volume":"99","author":"Pawankar","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2012.08.030_bib9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.173.3.747","article-title":"Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones","volume":"173","author":"Gascan","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2012.08.030_bib10","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/j.1460-2075.1993.tb05927.x","article-title":"Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction","volume":"12","author":"Zurawski","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2012.08.030_bib11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1073\/pnas.93.1.497","article-title":"Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor","volume":"93","author":"Hilton","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2012.08.030_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0014-5793(96)01462-7","article-title":"Cloning of the human IL-13R\u03b11 chain and reconstitution with the IL4R\u03b1 of a functional IL-4\/IL-13 receptor complex","volume":"401","author":"Miloux","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2012.08.030_bib13","doi-asserted-by":"crossref","first-page":"46073","DOI":"10.1074\/jbc.M209560200","article-title":"Kinetic analysis of the interleukin-13 receptor complex","volume":"277","author":"Andrews","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2012.08.030_bib14","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jaci.2006.06.041","article-title":"IL-13 receptor \u03b1 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts","volume":"118","author":"Andrews","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib15","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.4049\/jimmunol.161.5.2317","article-title":"The murine IL-13 receptor \u03b1 2: molecular cloning, characterization, and comparison with murine IL-13 receptor \u03b1 1","volume":"161","author":"Donaldson","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1006\/bbrc.1997.7082","article-title":"The competitive binding of STAT3 and NF-\u03baB on an overlapping DNA binding site","volume":"237","author":"Zhang","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2012.08.030_bib17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.immunol.17.1.701","article-title":"The IL-4 receptor: signaling mechanisms and biologic functions","volume":"17","author":"Nelms","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4049\/jimmunol.169.1.407","article-title":"Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells","volume":"169","author":"Lordan","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib19","doi-asserted-by":"crossref","first-page":"10387","DOI":"10.1074\/jbc.M108109200","article-title":"A novel mechanism by which interferon-\u03b3 can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor \u03b12 and their rapid mobilization by interferon-\u03b3","volume":"277","author":"Daines","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2012.08.030_bib20","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1125676","article-title":"Type 1 interferons and the virus-host relationship: a lesson in d\u00e9tente","volume":"312","author":"Garc\u00eda-Sastre","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jaci.2012.08.030_bib21","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01850","article-title":"Integration of interferon-\u03b1\/\u03b2 signalling to p53 responses in tumour suppression and antiviral defence","volume":"424","author":"Takaoka","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2012.08.030_bib22","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus","volume":"201","author":"Wark","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2012.08.030_bib23","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm1462","article-title":"Role of deficient type III interferon-lambda production in asthma exacerbations","volume":"12","author":"Contoli","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2012.08.030_bib24","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.4049\/jimmunol.0802471","article-title":"Contribution of bronchial fibroblasts to the antiviral response in asthma","volume":"182","author":"Bedke","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib25","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0006-291X(02)00380-7","article-title":"Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling","volume":"293","author":"Matsumoto","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2012.08.030_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-71272-2_1","article-title":"The immune response to influenza infection","volume":"128","author":"Ada","year":"1986","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/088282403322017857","article-title":"Rhinovirus and asthma","volume":"16","author":"Yamaya","year":"2003","journal-title":"Viral Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib28","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1172\/JCI117581","article-title":"A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects","volume":"94","author":"Calhoun","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2012.08.030_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1164\/ajrccm.156.2.9610079","article-title":"Experimental rhinovirus 16 infection. Effects on cell differentials and soluble markers in sputum in asthmatic subjects","volume":"156","author":"Grunberg","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"suppl","key":"10.1016\/j.jaci.2012.08.030_bib30","doi-asserted-by":"crossref","first-page":"157S","DOI":"10.1378\/chest.107.3_Supplement.157S","article-title":"Increased sensitivity to the consequences of rhinoviral infection in atopic subjects","volume":"107","author":"Bardin","year":"1995","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.08.030_bib31","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1183\/09031936.02.00247202","article-title":"Rhinovirus infection in nonasthmatic subjects: effects on intrapulmonary airways","volume":"20","author":"de Kluijver","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.08.030_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jaci.2008.03.028","article-title":"Virus-induced eosinophil mediator release requires antigen-presenting and CD4+ T cells","volume":"122","author":"Davoine","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2222.2009.03383.x","article-title":"Interleukin-13: prospects for new treatments","volume":"40","author":"Brightling","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.08.030_bib34","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1067\/mai.2001.118600","article-title":"IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism","volume":"108","author":"Pope","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib35","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1084\/jem.20020009","article-title":"Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma","volume":"195","author":"Mattes","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2012.08.030_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1165\/ajrcmb.25.3.4437","article-title":"The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma","volume":"25","author":"Richter","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2012.08.030_bib37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/thx.2005.050005","article-title":"Enhanced upregulation of smooth muscle related transcripts by TGF\u03b22 in asthmatic (Myo) fibroblasts","volume":"61","author":"Wicks","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2012.08.030_bib38","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394cT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jaci.2012.08.030_bib39","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.intimp.2007.07.002","article-title":"Double-stranded RNA increases kinin B1 receptor expression and function in human airway epithelial cells","volume":"7","author":"Bengtson","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaci.2012.08.030_bib40","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaci.2008.02.009","article-title":"Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: in\u00a0vivo and in\u00a0vitro studies","volume":"121","author":"Heinecke","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.08.030_bib41","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1136\/thx.2009.125930","article-title":"Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma","volume":"65","author":"Uller","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2012.08.030_bib42","doi-asserted-by":"crossref","first-page":"L951","DOI":"10.1152\/ajplung.00411.2010","article-title":"Rhinovirus infection induces extracellular matrix protein deposition in asthmatic and nonasthmatic airway smooth muscle cells","volume":"300","author":"Kuo","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2012.08.030_bib43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","article-title":"IL-13 signaling through the IL-13\u03b12 receptor is involved in induction of TGF\u03b21 production and fibrosis","volume":"12","author":"Fichtner-Feigl","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2012.08.030_bib44","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bmj.310.6989.1225","article-title":"Community study of role of viral infections in exacerbations of asthma in 9-11 year old children","volume":"310","author":"Johnston","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2012.08.030_bib45","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1164\/ajrccm.164.10.2102118","article-title":"Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection","volume":"164","author":"Grunberg","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.08.030_bib46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/jb\/mvm032","article-title":"Antiviral signaling through pattern recognition receptors","volume":"141","author":"Kawai","year":"2007","journal-title":"J Biochem"},{"key":"10.1016\/j.jaci.2012.08.030_bib47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1074-7613(00)80625-1","article-title":"Impaired development of Th2 cells in IL-13-deficient mice","volume":"9","author":"McKenzie","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2012.08.030_bib48","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1513\/pats.200907-072DP","article-title":"The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis","volume":"6","author":"Holgate","year":"2009","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaci.2012.08.030_bib49","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/thorax.57.4.328","article-title":"A defective type 1 response to rhinovirus in atopic asthma","volume":"57","author":"Papadopoulos","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2012.08.030_bib50","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1067\/mai.2000.105317","article-title":"Treatment with IFN-\u03b1 in corticosteroid-unresponsive asthma","volume":"105","author":"Gratzl","year":"2000","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912014315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912014315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:39:08Z","timestamp":1758789548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912014315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0091674912014315"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.08.030","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The innate antiviral response upregulates IL-13 receptor \u03b12 in bronchial fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.08.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}