{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:53:42Z","timestamp":1791212022054,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.jaci.2012.09.008","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T01:30:49Z","timestamp":1351819849000},"page":"1033-1040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"title":["Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: A\u00a0study within the Danish National Birth Cohort"],"prefix":"10.1016","volume":"131","author":[{"given":"Maria C.","family":"Harps\u00f8e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Basit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wohlfahrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Stabell","family":"Benn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen A.","family":"N\u00f8hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Jess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.09.008_bib1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1053\/j.gastro.2007.03.052","article-title":"The epidemiology of obesity","volume":"132","author":"Ogden","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2012.09.008_bib2","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/oby.2004.183","article-title":"Major increase in prevalence of overweight and obesity between 1987 and 2001 among Danish adults","volume":"12","author":"Bendixen","year":"2004","journal-title":"Obes Res"},{"issue":"7 Pt 2","key":"10.1016\/j.jaci.2012.09.008_bib3","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1111\/j.1753-4887.2004.tb00079.x","article-title":"Pregnancy-related weight gain\u2013a link to obesity?","volume":"62","author":"Siega-Riz","year":"2004","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jaci.2012.09.008_bib4","series-title":"Weight Gain During Pregnancy: Reexamining the Guidelines","author":"Rasmussen","year":"2009"},{"key":"10.1016\/j.jaci.2012.09.008_bib5","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1398-9995.2007.01506.x","article-title":"The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance?","volume":"62","author":"Hersoug","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.09.008_bib6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0899-9007(01)00672-4","article-title":"Is obesity an inflammatory condition?","volume":"17","author":"Das","year":"2001","journal-title":"Nutrition"},{"key":"10.1016\/j.jaci.2012.09.008_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pharmthera.2005.10.002","article-title":"Obesity and asthma","volume":"110","author":"Shore","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jaci.2012.09.008_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1152\/japplphysiol.00847.2006","article-title":"Obesity and asthma: lessons from animal models","volume":"102","author":"Shore","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jaci.2012.09.008_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","article-title":"Adipokines: inflammation and the pleiotropic role of white adipose tissue","volume":"92","author":"Trayhurn","year":"2004","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jaci.2012.09.008_bib10","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1001\/jama.282.22.2131","article-title":"Elevated C-reactive protein levels in overweight and obese adults","volume":"282","author":"Visser","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2012.09.008_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-2891-6-3","article-title":"Body mass index, percent body fat, and regional body fat distribution in relation to leptin concentrations in healthy, non-smoking postmenopausal women in a feeding study","volume":"6","author":"Mahabir","year":"2007","journal-title":"Nutr J"},{"key":"10.1016\/j.jaci.2012.09.008_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mce.2004.03.002","article-title":"Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects","volume":"219","author":"Lihn","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jaci.2012.09.008_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jaci.2004.10.007","article-title":"Effect of leptin on allergic airway responses in mice","volume":"115","author":"Shore","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.09.008_bib14","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/thx.2004.031468","article-title":"Association between leptin and asthma in adults","volume":"61","author":"Sood","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2012.09.008_bib15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jaci.2004.03.053","article-title":"Leptin: does it have any role in childhood asthma?","volume":"114","author":"Guler","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.09.008_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1399-3038.2008.00740.x","article-title":"Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren","volume":"20","author":"Nagel","year":"2009","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.09.008_bib17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jaci.2006.04.021","article-title":"Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice","volume":"118","author":"Shore","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.09.008_bib18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/ACI.0b013e328349b166","article-title":"Early life exposures: impact on asthma and allergic disease","volume":"11","author":"Kozyrskyj","year":"2011","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.09.008_bib19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1378\/chest.10-1800","article-title":"Epigenetics and prenatal influences on asthma and allergic airways disease","volume":"139","author":"Martino","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.09.008_bib20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-3016.2009.01034.x","article-title":"Maternal obesity in pregnancy and respiratory health in early childhood","volume":"23","author":"Haberg","year":"2009","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.jaci.2012.09.008_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1089\/ped.2010.0032","article-title":"Maternal pre-pregnancy obesity and recurrent wheezing in early childhood","volume":"23","author":"Kumar","year":"2010","journal-title":"Pediatr Allergy Immunol Pulmonol"},{"key":"10.1016\/j.jaci.2012.09.008_bib22","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jaci.2011.08.025","article-title":"Maternal obesity during pregnancy as a risk for early-life asthma","volume":"128","author":"Lowe","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.09.008_bib23","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/jech.2011.133777","article-title":"Associations between pre-pregnancy obesity and asthma symptoms in adolescents","volume":"66","author":"Patel","year":"2012","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.jaci.2012.09.008_bib24","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10995-007-0292-2","article-title":"Maternal pre-pregnancy obesity and diagnosis of asthma in offspring at age 3 years","volume":"12","author":"Reichman","year":"2008","journal-title":"Matern Child Health J"},{"key":"10.1016\/j.jaci.2012.09.008_bib25","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/ijo.2009.194","article-title":"Maternal overweight before pregnancy and asthma in offspring followed for 8 years","volume":"34","author":"Scholtens","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jaci.2012.09.008_bib26","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/oxfordjournals.aje.a008787","article-title":"Pre- and perinatal risk factors for asthma in inner city African-American children","volume":"143","author":"Oliveti","year":"1996","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaci.2012.09.008_bib27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1164\/rccm.200512-1978OC","article-title":"Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children","volume":"175","author":"Rusconi","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.09.008_bib28","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1093\/ajcn\/87.6.1750","article-title":"Combined associations of prepregnancy body mass index and gestational weight gain with the outcome of pregnancy","volume":"87","author":"Nohr","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jaci.2012.09.008_bib29","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/14034948010290040201","article-title":"The Danish National Birth Cohort\u2013its background, structure and aim","volume":"29","author":"Olsen","year":"2001","journal-title":"Scand J Public Health"},{"key":"10.1016\/j.jaci.2012.09.008_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10995-006-0157-0","article-title":"Validity of self-reported height and weight in women of reproductive age","volume":"11","author":"Brunner Huber","year":"2007","journal-title":"Matern Child Health J"},{"key":"10.1016\/j.jaci.2012.09.008_bib31","series-title":"Obesity: Preventing aManaging the Global Epidemic","year":"2000"},{"key":"10.1016\/j.jaci.2012.09.008_bib32","series-title":"Nutrition During Pregnancy: Part I: Weight Gain; Part II: Nutrient Supplements","year":"1990"},{"key":"10.1016\/j.jaci.2012.09.008_bib33","series-title":"Phase II Modules of The International Study of Asthma and Allergies in Childhood (ISAAC)","year":"1998"},{"key":"10.1016\/j.jaci.2012.09.008_bib34","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1378\/chest.104.2.600","article-title":"Asthma and asthma-like symptoms in adults assessed by questionnaires. A\u00a0literature review","volume":"104","author":"Toren","year":"1993","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.09.008_bib35","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1034\/j.1398-9995.1999.00044.x","article-title":"Different pattern of risk factors for atopic and nonatopic asthma among children\u2013report from the Obstructive Lung Disease in Northern Sweden Study","volume":"54","author":"Ronmark","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.09.008_bib36","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2133.1994.tb08532.x","article-title":"The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation","volume":"131","author":"Williams","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2012.09.008_bib37","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1365-2133.2007.08412.x","article-title":"Diagnostic criteria for atopic dermatitis: a systematic review","volume":"158","author":"Brenninkmeijer","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2012.09.008_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/00015550310006563","article-title":"Atopic dermatitis in young children: diagnostic criteria for use in epidemiological studies based on telephone interviews","volume":"83","author":"Benn","year":"2003","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2012.09.008_bib39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/sj.ijo.0801515","article-title":"Body mass index of 0 to 45-y-old Danes: reference values and comparison with published European reference values","volume":"25","author":"Nysom","year":"2001","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.jaci.2012.09.008_bib40","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1183\/09031936.06.00008406","article-title":"Parental understanding of wheeze and its impact on asthma prevalence estimates","volume":"28","author":"Michel","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.09.008_bib41","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1542\/peds.2004-0897","article-title":"Racial and ethnic differences in asthma diagnosis among children who wheeze","volume":"115","author":"Akinbami","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2012.09.008_bib42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/aje\/154.3.245","article-title":"Predictors of asthma in young children: does reporting source affect our conclusions?","volume":"154","author":"Miller","year":"2001","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaci.2012.09.008_bib43","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1183\/09031936.00002108","article-title":"Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach","volume":"32","author":"Brand","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.09.008_bib44","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/02770900600878974","article-title":"Characteristics of early transient, persistent, and late onset wheezers at 9 to 11 years of age","volume":"43","author":"De","year":"2006","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2012.09.008_bib45","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1038\/oby.2006.240","article-title":"Underreporting of BMI in adults and its effect on obesity prevalence estimations in the period 1998 to 2001","volume":"14","author":"Visscher","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jaci.2012.09.008_bib46","unstructured":"Nohr EA. Obesity in pregnancy. Appendix A. Epidemiological studies based on the Danish National Birth Cohort. PhD thesis. Faculty of Health Sciences. University of Aarhus; 2005."},{"key":"10.1016\/j.jaci.2012.09.008_bib47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10654-010-9448-2","article-title":"Selection by socioeconomic factors into the Danish National Birth Cohort","volume":"25","author":"Jacobsen","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jaci.2012.09.008_bib48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/01.ede.0000220549.14177.60","article-title":"Does low participation in cohort studies induce bias?","volume":"17","author":"Nohr","year":"2006","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaci.2012.09.008_bib49","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/EDE.0b013e31822939fd","article-title":"Estimating bias from loss to follow-up in the Danish National Birth Cohort","volume":"22","author":"Greene","year":"2011","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaci.2012.09.008_bib50","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3109\/02770903.2010.489388","article-title":"Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999-2006","volume":"47","author":"Visness","year":"2010","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2012.09.008_bib51","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.maturitas.2012.04.012","article-title":"The obesity paradox: methodological considerations based on epidemiological and clinical evidence-new insights","volume":"72","author":"Kastorini","year":"2012","journal-title":"Maturitas"},{"key":"10.1016\/j.jaci.2012.09.008_bib52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12603-011-0073-x","article-title":"A systematic review of the literature concerning the relationship between obesity and mortality in the elderly","volume":"16","author":"Donini","year":"2012","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.jaci.2012.09.008_bib53","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1001\/jama.298.17.2028","article-title":"Cause-specific excess deaths associated with underweight, overweight, and obesity","volume":"298","author":"Flegal","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2012.09.008_bib54","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1467-789X.2010.00741.x","article-title":"Childhood body mass index and risk of asthma in adolescence: a systematic review","volume":"12","author":"Noal","year":"2011","journal-title":"Obes Rev"},{"key":"10.1016\/j.jaci.2012.09.008_bib55","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3109\/02770903.2011.611956","article-title":"U-shaped association between body mass index and the prevalence of wheeze and asthma, but not eczema or rhinoconjunctivitis: the ryukyus child health study","volume":"48","author":"Tanaka","year":"2011","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2012.09.008_bib56","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1398-9995.2011.02587.x","article-title":"Maternal immune status in pregnancy is related to offspring's immune responses and atopy risk","volume":"66","author":"Herberth","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.09.008_bib57","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N Engl J Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912015023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912015023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:38:07Z","timestamp":1758789487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912015023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0091674912015023"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.09.008","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: A\u00a0study within the Danish National Birth Cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}