{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:18Z","timestamp":1788872418872,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1UL1RR025011"],"award-info":[{"award-number":["1UL1RR025011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32 CA009206-31"],"award-info":[{"award-number":["5T32 CA009206-31"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL070831"],"award-info":[{"award-number":["P01 HL070831"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006792","name":"Hartwell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.jaci.2012.10.032","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T18:30:31Z","timestamp":1355250631000},"page":"369-376.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Pulmonary 3He magnetic resonance imaging of childhood asthma"],"prefix":"10.1016","volume":"131","author":[{"given":"Robert V.","family":"Cadman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert F.","family":"Lemanske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Sorkness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean B.","family":"Fain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.10.032_bib1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1378\/chest.07-2779","article-title":"Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology","volume":"134","author":"Aysola","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.10.032_bib2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1378\/chest.08-0049","article-title":"A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis","volume":"135","author":"Busacker","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.10.032_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1164\/rccm.200505-810OC","article-title":"Estimation of cancer mortality associated with repetitive computed tomography scanning","volume":"173","author":"de Jong","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib5","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1164\/rccm.200702-212OC","article-title":"Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers","volume":"176","author":"Saglani","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib6","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/jmri.22388","article-title":"Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium-3 MRI","volume":"32","author":"Aysola","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jaci.2012.10.032_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/RTI.0b013e3181b32bec","article-title":"Hyperpolarized gas MR Imaging of the lung: current status as a research tool","volume":"24","author":"Matsuoka","year":"2009","journal-title":"J Thorac Imaging"},{"issue":"suppl","key":"10.1016\/j.jaci.2012.10.032_bib8","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/j.jaci.2009.10.002","article-title":"Imaging of the distal airways","volume":"124","author":"Tashkin","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.10.032_bib9","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/jmri.22375","article-title":"Imaging of lung function using hyperpolarized helium-3 magnetic resonance imaging: review of current and emerging translational methods and applications","volume":"32","author":"Fain","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jaci.2012.10.032_bib10","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/jmri.20876","article-title":"Functional lung imaging using hyperpolarized gas MRI","volume":"25","author":"Fain","year":"2007","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jaci.2012.10.032_bib11","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1152\/japplphysiol.00738.2006","article-title":"Advances in\u00a0magnetic resonance imaging of lung physiology","volume":"102","author":"Hopkins","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jaci.2012.10.032_bib12","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1067\/mai.2003.1544","article-title":"Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge","volume":"111","author":"Samee","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.10.032_bib13","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1378\/chest.130.4.1055","article-title":"Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry","volume":"130","author":"de Lange","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2012.10.032_bib14","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.acra.2007.10.019","article-title":"Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized He-3 MRI","volume":"15","author":"Fain","year":"2008","journal-title":"Acad Radiol"},{"key":"10.1016\/j.jaci.2012.10.032_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/1522-2594(200008)44:2<174::AID-MRM2>3.0.CO;2-4","article-title":"MR imaging of diffusion of 3He gas in healthy and diseased lungs","volume":"44","author":"Saam","year":"2000","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib16","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1148\/radiol.2221001834","article-title":"Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes\u2014initial experience","volume":"222","author":"Salerno","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.jaci.2012.10.032_bib17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1148\/radiol.10091937","article-title":"Chronic obstructive pulmonary disease: longitudinal hyperpolarized 3He MR imaging","volume":"256","author":"Kirby","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.jaci.2012.10.032_bib18","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1148\/radiol.2393050111","article-title":"Early emphysematous changes in asymptomatic smokers: detection with 3He MR imaging","volume":"239","author":"Fain","year":"2006","journal-title":"Radiology"},{"issue":"suppl\u00a015","key":"10.1016\/j.jaci.2012.10.032_bib19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1034\/j.1399-3038.13.s.15.8.x","article-title":"The childhood origins of asthma (COAST) study","volume":"13","author":"Lemanske","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.10.032_bib20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1164\/ajrccm.163.3.2002054","article-title":"Spirometric pulmonary function in healthy preschool children","volume":"163","author":"Eigen","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1399-3038.2002.01093.x","article-title":"Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy","volume":"13","author":"Gern","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.10.032_bib22","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jaci.2011.06.037","article-title":"Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma","volume":"128","author":"Guilbert","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.10.032_bib23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1183\/09031936.05.00035005","article-title":"Standardisation of the measurement of lung volumes","volume":"26","author":"Wanger","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2012.10.032_bib24","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/mrm.22150","article-title":"Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction","volume":"62","author":"Holmes","year":"2009","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib25","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/mrm.21437","article-title":"3D hyperpolarized He-3 MRI of ventilation using a multi-echo projection acquisition","volume":"59","author":"Holmes","year":"2008","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/mrm.21439","article-title":"Iterative projection reconstruction of time-resolved images using highly-constrained back-projection (HYPR)","volume":"59","author":"O'Halloran","year":"2008","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/rccm.201107-1348OC","article-title":"Alveolarization continues during childhood and adolescence: new evidence from helium-3 magnetic resonance","volume":"185","author":"Narayanan","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/mrm.22158","article-title":"Helium-3 MR q-space imaging with radial acquisition and iterative highly constrained back-projection","volume":"63","author":"O'Halloran","year":"2010","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib29","article-title":"Exercise-induced bronchoconstriction: reproducibility of hyperpolarized 3HE MR imaging","author":"Niles","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.jaci.2012.10.032_bib30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tem.2007.08.003","article-title":"It's all about sex: gender, lung development and lung disease","volume":"18","author":"Carey","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jaci.2012.10.032_bib31","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jmri.1054","article-title":"Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings","volume":"13","author":"Altes","year":"2001","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jaci.2012.10.032_bib32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/ppul.20373","article-title":"Factors influencing gender differences in the diagnosis and treatment of asthma in childhood: the Tucson Children's Respiratory Study","volume":"41","author":"Wright","year":"2006","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2012.10.032_bib33","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jaci.2011.11.017","article-title":"The role of the small airways in the clinical expression of asthma in adults","volume":"129","author":"Farah","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.10.032_bib34","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1164\/rccm.200309-1234OE","article-title":"Is forced expiratory volume in one second the best measure of severity in childhood asthma?","volume":"169","author":"Spahn","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.10.032_bib35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jmri.21408","article-title":"Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPD","volume":"28","author":"Wang","year":"2008","journal-title":"J Magn Reson Imaging"},{"issue":"suppl\u00a015","key":"10.1016\/j.jaci.2012.10.032_bibE1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1034\/j.1399-3038.13.s.15.8.x","article-title":"The childhood origins of asthma (COAST) study","volume":"13","author":"Lemanske","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.10.032_bibE2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1399-3038.2002.01093.x","article-title":"Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy","volume":"13","author":"Gern","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.10.032_bibE3","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.10.032_bibE4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/mrm.21439","article-title":"Iterative projection reconstruction of time-resolved images using highly-constrained back-projection (HYPR)","volume":"59","author":"O'Halloran","year":"2008","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bibE5","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/mrm.22150","article-title":"Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction","volume":"62","author":"Holmes","year":"2009","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bibE6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/1522-2594(200008)44:2<174::AID-MRM2>3.0.CO;2-4","article-title":"MR imaging of diffusion of 3He gas in healthy and diseased lungs","volume":"44","author":"Saam","year":"2000","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bibE7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1148\/radiol.2221001834","article-title":"Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes\u2014initial experience","volume":"222","author":"Salerno","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.jaci.2012.10.032_bibE8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1148\/radiol.10091937","article-title":"Chronic obstructive pulmonary disease: longitudinal hyperpolarized 3He MR imaging","volume":"256","author":"Kirby","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.jaci.2012.10.032_bibE9","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1148\/radiol.2393050111","article-title":"Early emphysematous changes in asymptomatic smokers: detection with 3He MR imaging","volume":"239","author":"Fain","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.jaci.2012.10.032_bibE10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jmri.21408","article-title":"Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPD","volume":"28","author":"Wang","year":"2008","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jaci.2012.10.032_bibE11","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/mrm.21076","article-title":"Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema","volume":"56","author":"Woods","year":"2006","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jaci.2012.10.032_bibE12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jmr.2007.10.015","article-title":"In\u00a0vivo lung morphometry with hyperpolarized 3He diffusion MRI: theoretical background","volume":"190","author":"Sukstanskii","year":"2008","journal-title":"J Magn Reson"},{"key":"10.1016\/j.jaci.2012.10.032_bibE13","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1073\/pnas.052594699","article-title":"Quantitative in\u00a0vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI","volume":"99","author":"Yablonskiy","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2012.10.032_bibE14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/jmri.20618","article-title":"q-Space analysis of lung morphometry in\u00a0vivo with hyperpolarized 3He spectroscopy","volume":"24","author":"Shanbhag","year":"2006","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jaci.2012.10.032_bibE15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/rccm.201107-1348OC","article-title":"Alveolarization continues during childhood and adolescence: new evidence from helium-3 magnetic resonance","volume":"185","author":"Narayanan","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.10.032_bibE16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/mrm.22158","article-title":"Helium-3 MR q-space imaging with radial acquisition and iterative highly constrained back-projection","volume":"63","author":"O'Halloran","year":"2010","journal-title":"Magn Reson Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912017009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912017009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:37:31Z","timestamp":1758789451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912017009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0091674912017009"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.10.032","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary 3He magnetic resonance imaging of childhood asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.10.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}