{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:49:48Z","timestamp":1772120988332,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.jaci.2012.10.043","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T01:45:40Z","timestamp":1356659140000},"page":"1683-1690","source":"Crossref","is-referenced-by-count":40,"title":["Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma\/wheeze in an urban tropical population in Brazil"],"prefix":"10.1016","volume":"131","author":[{"given":"Camila Alexandrina","family":"Figueiredo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Lima","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neuza Maria","family":"Alcantara-Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Cunha","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip John","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro A.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lain Carlos","family":"Pontes-de-Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise C.","family":"Lemaire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"dos Santos Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila D.","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candelaria","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Rafaels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasika A.","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen C.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.10.043_bib1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2012.10.043_bib2","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.trstmh.2007.05.014","article-title":"The hygiene hypothesis and the increasing prevalence of chronic inflammatory disorders","volume":"101","author":"Rook","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jaci.2012.10.043_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri1183","article-title":"Immune regulation by helminth parasites: cellular and molecular mechanisms","volume":"3","author":"Maizels","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2012.10.043_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ncpgasthep0471","article-title":"Mechanisms of disease: the hygiene hypothesis revisited","volume":"3","author":"Guarner","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.jaci.2012.10.043_bib5","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1128\/IAI.01228-09","article-title":"Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network","volume":"78","author":"Figueiredo","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2012.10.043_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.clim.2010.12.019","article-title":"Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment","volume":"139","author":"Figueiredo","year":"2011","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2012.10.043_bib7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1289\/ehp.0800366","article-title":"Spontaneous cytokine production in children according to biological characteristics and environmental exposures","volume":"117","author":"Figueiredo","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jaci.2012.10.043_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2466-6-15","article-title":"Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study)","volume":"6","author":"Barreto","year":"2006","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jaci.2012.10.043_bib9","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1111\/j.1365-2222.2008.03027.x","article-title":"Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood","volume":"38","author":"Rodrigues","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.10.043_bib10","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1289\/ehp.1002058","article-title":"Impact of a citywide sanitation programme in Northeast Brazil on intestinal parasites infection in young children","volume":"118","author":"Barreto","year":"2010","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jaci.2012.10.043_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1050-3862(98)00019-9","article-title":"Allelic discrimination using fluorogenic probes and the 5' nuclease assay","volume":"14","author":"Livak","year":"1999","journal-title":"Genet Anal"},{"key":"10.1016\/j.jaci.2012.10.043_bib12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jaci.2011.09.015","article-title":"The effect of single and multiple infections on atopy and wheezing in children","volume":"129","author":"Alcantara-Neves","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.10.043_bib13","first-page":"281","article-title":"The sedimentation concentration method in Schistosomiasis mansoni","volume":"9","author":"Hoffman","year":"1934","journal-title":"Puerto Rico J Public Health"},{"key":"10.1016\/j.jaci.2012.10.043_bib14","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni","volume":"14","author":"Katz","year":"1972","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"10.1016\/j.jaci.2012.10.043_bib15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2012.10.043_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-2288-8-70","article-title":"Reducing bias through directed acyclic graphs","volume":"8","author":"Shrier","year":"2008","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jaci.2012.10.043_bib17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nri2039","article-title":"Suppression of TH2-type allergic reactions by helminth infection","volume":"7","author":"Fallon","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2012.10.043_bib18","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"Anthony","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2012.10.043_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/ACI.0b013e32831f44a6","article-title":"Interactions between helminth parasites and allergy","volume":"9","author":"Cooper","year":"2009","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.10.043_bib20","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1084\/jem.20042572","article-title":"Suppression of allergic airway inflammation by helminth-induced regulatory T cells","volume":"202","author":"Wilson","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2012.10.043_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.imbio.2007.03.006","article-title":"Epidemiological and immunological evidence for the hygiene hypothesis","volume":"212","author":"Garn","year":"2007","journal-title":"Immunobiology"},{"key":"10.1016\/j.jaci.2012.10.043_bib22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/gene.2010.50","article-title":"Polymorphisms in IL10 are associated with total immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population","volume":"12","author":"Grant","year":"2011","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2012.10.043_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jaci.2008.03.015","article-title":"Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations","volume":"122","author":"Hunninghake","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.10.043_bib24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1517\/14712598.8.6.769","article-title":"T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches","volume":"8","author":"Akdis","year":"2008","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jaci.2012.10.043_bib25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.meegid.2011.03.017","article-title":"Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis","volume":"11","author":"Abhimanyu","year":"2011","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.jaci.2012.10.043_bib26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/1471-2148-10-264","article-title":"The landscape of human genes involved in the immune response to parasitic worms","volume":"10","author":"Fumagalli","year":"2010","journal-title":"BMC Evol Biol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912017642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912017642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T22:07:18Z","timestamp":1714774038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912017642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0091674912017642"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.10.043","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717976641.793470501","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}