{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T22:17:21Z","timestamp":1774909041148,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jaci.2012.12.671","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T17:33:35Z","timestamp":1359567215000},"page":"772-780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3"],"prefix":"10.1016","volume":"131","author":[{"given":"Se Jin","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Joon","family":"Jun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyei Yul","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Jin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Yoon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyu Ho","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hag","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2012.12.671_bib1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van Zele","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.12.671_bib2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s11882-002-0027-9","article-title":"Staphylococcus aureus superantigens and airway disease","volume":"2","author":"Bachert","year":"2002","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2012.12.671_bib3","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jaci.2004.08.012","article-title":"Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi","volume":"114","author":"Shin","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib4","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1097\/00005537-200006000-00031","article-title":"Nasal interleukin-5, immunoglobulin E, eosinophilic cationic protein, and soluble intercellular adhesion molecule-1 in chronic sinusitis, allergic rhinitis, and nasal polyposis","volume":"110","author":"Kramer","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2012.12.671_bib5","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2500\/ajr.2008.22.3228","article-title":"Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis","volume":"22","author":"Kern","year":"2008","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2012.12.671_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.otohns.2006.11.011","article-title":"Innate immunity of the sinonasal cavity and its role in chronic rhinosinusitis","volume":"136","author":"Ramanathan","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2012.12.671_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaci.2004.09.029","article-title":"Rhinosinusitis: establishing definitions for clinical research and patient care","volume":"114","author":"Meltzer","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib8","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.jaci.2008.02.018","article-title":"T-cell regulation in chronic paranasal sinus disease","volume":"121","author":"Van Bruene","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1465-9921-12-28","article-title":"The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis","volume":"12","author":"Lu","year":"2011","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2012.12.671_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/ar1741","article-title":"Negative regulation of cytokine signaling and immune responses by SOCS proteins","volume":"7","author":"Yoshimura","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jaci.2012.12.671_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.immunol.18.1.143","article-title":"Negative regulation of cytokine signaling pathways","volume":"18","author":"Yasukawa","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nri818","article-title":"Suppressors of cytokine signalling (SOCS) in the immune system","volume":"2","author":"Alexander","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib13","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1053\/gast.2002.37068","article-title":"Suppressors of cytokine signaling: relevance to gastrointestinal function and disease","volume":"123","author":"Greenhalgh","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2012.12.671_bib14","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ni1012","article-title":"Suppressors of cytokine signaling and immunity","volume":"4","author":"Kubo","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1165\/rcmb.2006-0090OC","article-title":"Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma","volume":"36","author":"Harada","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2012.12.671_bib16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm896","article-title":"SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses","volume":"9","author":"Seki","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2012.12.671_bib17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1365-2222.2007.02913.x","article-title":"Association between suppressors of cytokine signaling, T-helper type 1\/T-helper type 2 balance and allergic sensitization in children","volume":"38","author":"Daegelmann","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2012.12.671_bib18","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/hn.2003.v128.amhn0312811","article-title":"Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology","volume":"129","author":"Benninger","year":"2003","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2012.12.671_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0194-5998(97)70001-9","article-title":"Adult rhinosinusitis defined: report of the Rhinosinusitis Task Force Committee Meeting","volume":"117","author":"Lanza","year":"1997","journal-title":"Otlaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2012.12.671_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0194-5998(97)70005-6","article-title":"Staging for rhinosinusitis","volume":"107","author":"Lund","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2012.12.671_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1067\/mhn.2002.121022","article-title":"Psychometric and clinimetric validity of the 20-item Sino-Nasal Outcome Test (SNOT-20)","volume":"126","author":"Piccirillo","year":"2002","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2012.12.671_bib22","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"3","author":"Fokkens","year":"2012","journal-title":"Rhinol Suppl"},{"key":"10.1016\/j.jaci.2012.12.671_bib23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/MOO.0b013e3282fb2885","article-title":"The role of cytokines in chronic rhinosinusitis with nasal polyps","volume":"16","author":"Otto","year":"2008","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2012.12.671_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0065-2776(09)03003-X","article-title":"Chapter 3: role of SOCS in allergic and innate immune responses","volume":"103","author":"Cassel","year":"2009","journal-title":"Adv Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000333103","article-title":"Expression of SOCS1 and SOCS3 is altered in the nasal mucosa of patients with mild and moderate\/severe persistent allergic rhinitis","volume":"158","author":"Kim","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib26","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1600-0765.2006.00908.x","article-title":"Expression of suppressors of cytokine signaling in diseased periodontal tissues: a stop signal for disease progression?","volume":"41","author":"Garlet","year":"2006","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jaci.2012.12.671_bib27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/intimm\/dxn033","article-title":"Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice","volume":"20","author":"Horino","year":"2008","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib28","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1084\/jem.193.4.471","article-title":"CIS\/SOCS3\/SSIS3 plays a negative regulatory role in STAT3 activation and intestinal inflammation","volume":"193","author":"Suzaki","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2012.12.671_bib29","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1681\/ASN.2004050374","article-title":"Suppressors of cytokine signaling regulate angiotensin II-activated Janus kinase-signal transducers and activators of transcription pathway in renal cells","volume":"16","author":"Hern\u00e1ndez-Vargas","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jaci.2012.12.671_bib30","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1046\/j.1471-4159.2002.01208.x","article-title":"Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia","volume":"83","author":"Raghavendra Rao","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.jaci.2012.12.671_bib31","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1128\/JVI.01138-08","article-title":"SOCS-1 mimetics protect mice against lethal poxvirus infection: identification of a novel endogenous antiviral system","volume":"83","author":"Ahmed","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2012.12.671_bib32","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1164\/rccm.200806-992OC","article-title":"Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype","volume":"179","author":"Fukuyama","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2012.12.671_bib33","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.it.2009.07.001","article-title":"SOCS1 and SOCS3 in the control of CNS immunity","volume":"30","author":"Baker","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1465-9921-9-84","article-title":"IFN-\u03b3, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13","volume":"9","author":"Moynihan","year":"2008","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2012.12.671_bib35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1513\/pats.201006-038RN","article-title":"Microbiology of sinusitis","volume":"8","author":"Brook","year":"2011","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaci.2012.12.671_bib36","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0194-5998(99)70331-1","article-title":"Mucin production in the middle ear in response to lipopolysaccharides","volume":"120","author":"Hunter","year":"1999","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2012.12.671_bib37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/000348940311200514","article-title":"Effects of bacterial toxins on air-exposed cultured human respiratory sinus epithelium","volume":"112","author":"Nell","year":"2003","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.jaci.2012.12.671_bib38","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/j.1398-9995.2011.02678.x","article-title":"Adaptive immune responses in Staphylococcus aureus biofilm-associated chronic rhinosinusitis","volume":"66","author":"Foreman","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2012.12.671_bib39","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0091-6749(95)70298-9","article-title":"Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis","volume":"96","author":"Hamilos","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2012.12.671_bib40","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2500\/105065800781329573","article-title":"Nasal polyposis: from cytokines to growth","volume":"14","author":"Bachert","year":"2000","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2012.12.671_bib41","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4049\/jimmunol.169.1.434","article-title":"Impaired IFN-\u03b3-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1","volume":"168","author":"Federici","year":"2002","journal-title":"J Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912026723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674912026723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:41:25Z","timestamp":1758789685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674912026723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0091674912026723"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2012.12.671","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2012.12.671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}