{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:10:55Z","timestamp":1791173455701,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.jaci.2013.03.019","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T11:13:59Z","timestamp":1367406839000},"page":"1342-1349.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":151,"title":["Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults"],"prefix":"10.1016","volume":"131","author":[{"given":"Peter S.","family":"Creticos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Maloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Casale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjot","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00f3f","family":"N\u00e9k\u00e1m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2013.03.019_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1081-1206(10)61509-8","article-title":"Key pollen allergens in North America","volume":"91","author":"White","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000108134","article-title":"Prevalence of IgE-binding to Art v 1, Art v 4 and Amb a 1 in mugwort-allergic patients","volume":"145","author":"Oberhuber","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib3","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1365-2222.2006.02477.x","article-title":"Artemisia and ambrosia hypersensitivity: co-sensitization or co-recognition?","volume":"36","author":"Asero","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2013.03.019_bib4","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/j.1398-9995.2008.01780.x","article-title":"Array-based profiling of ragweed and mugwort pollen allergens","volume":"63","author":"Gadermaier","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2013.03.019_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jaci.2005.05.017","article-title":"Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey","volume":"116","author":"Arbes","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib6","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1073\/pnas.1014107108","article-title":"Recent warming by latitude associated with increased length of ragweed pollen season in central North America","volume":"108","author":"Ziska","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2013.03.019_bib7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1398-9995.2009.01975.x","article-title":"Ragweed sensitization in Europe - GA(2)LEN study suggests increasing prevalence","volume":"64","author":"Burbach","year":"2009","journal-title":"Allergy"},{"issue":"1 Suppl","key":"10.1016\/j.jaci.2013.03.019_bib8","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.09.034","article-title":"Allergen immunotherapy: a practice parameter third update","volume":"127","author":"Cox","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.7326\/0003-4819-75-5-663","article-title":"A single year of immunotherapy for ragweed hay fever. Immunologic and clinical studies","volume":"75","author":"Lichtenstein","year":"1971","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaci.2013.03.019_bib10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1172\/JCI105419","article-title":"In\u00a0vitro studies of human ragweed allergy: changes in cellular and humoral activity associated with specific desensitization","volume":"45","author":"Lichtenstein","year":"1966","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2013.03.019_bib11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jaci.2011.12.973","article-title":"SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial","volume":"129","author":"Durham","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/alr.21037","article-title":"A comparison of attrition rates in patients undergoing sublingual immunotherapy vs subcutaneous immunotherapy","volume":"2","author":"Hsu","year":"2012","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2013.03.019_bib13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.anai.2011.05.020","article-title":"Immediate and delayed-onset systemic reactions after subcutaneous immunotherapy injections: ACAAI\/AAAAI surveillance study of subcutaneous immunotherapy: year 2","volume":"107","author":"Epstein","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib14","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.jaci.2004.02.006","article-title":"Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001","volume":"113","author":"Bernstein","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jaci.2008.10.044","article-title":"Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy","volume":"123","author":"Bufe","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jaci.2008.10.009","article-title":"Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis","volume":"123","author":"Wahn","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jaci.2011.06.022","article-title":"Sustained 3-year efficacy of pre- and coseasonal 5-grass-pollen sublingual immunotherapy tablets in patients with grass pollen-induced rhinoconjunctivitis","volume":"128","author":"Didier","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaci.2010.11.034","article-title":"Efficacy and safety of timothy grass allergy immunotherapy tablets in North American children and adolescents","volume":"127","author":"Blaiss","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2010.11.035","article-title":"Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults","volume":"127","author":"Nelson","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib20","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jaci.2009.12.931","article-title":"Sublingual immunotherapy in patients with allergic rhinoconjunctivitis caused by ragweed pollen","volume":"125","author":"Skoner","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000070926","article-title":"A double-blind placebo-controlled evaluation of sublingual immunotherapy with a standardized ragweed extract in patients with seasonal rhinitis. Evidence for a dose-response relationship","volume":"131","author":"Andr\u00e9","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1081-1206(10)61408-1","article-title":"Canadian trial of sublingual swallow immunotherapy for ragweed rhinoconjunctivitis","volume":"93","author":"Bowen","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1081-1206(10)60474-7","article-title":"Sublingual-oral administration of standardized allergenic extracts: phase 1 safety and dosing results","volume":"100","author":"Esch","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib24","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2500\/aap.2012.33.3605","article-title":"Safety of ragweed sublingual allergy immunotherapy tablets in adults with allergic rhinoconjunctivitis","volume":"33","author":"Nayak","year":"2012","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaci.2013.03.019_bib25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jaci.2009.07.054","article-title":"Recommendations for appropriate sublingual immunotherapy clinical trials","volume":"124","author":"Casale","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 91","key":"10.1016\/j.jaci.2013.03.019_bib26","first-page":"1","article-title":"Sub-lingual immunotherapy: World Allergy Organization Position Paper 2009","volume":"64","author":"Canonica","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2013.03.019_bib27","series-title":"Guideline on the clinical development of products for specific immunotherapy for the treatment of allergic diseases","year":"2009"},{"key":"10.1016\/j.jaci.2013.03.019_bib28","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaci.2007.10.039","article-title":"Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years","volume":"121","author":"Dahl","year":"2008","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 86","key":"10.1016\/j.jaci.2013.03.019_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2013.03.019_bib30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0091-6749(84)90490-1","article-title":"Dose response of IgE and IgG antibodies during ragweed immunotherapy","volume":"73","author":"Creticos","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0091-6749(82)90062-8","article-title":"Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study","volume":"70","author":"Gleich","year":"1982","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib32","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1398-9995.2011.02590.x","article-title":"How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA-GA(2)LEN statement","volume":"66","author":"Bousquet","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2013.03.019_bib33","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jaci.2011.04.048","article-title":"Sublingual immunotherapy: allergen specific or placebo effect?","volume":"128","author":"Kette","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.03.019_bib34","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMoa052916","article-title":"Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis","volume":"355","author":"Creticos","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2013.03.019_bib35","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1056\/NEJM196509232731302","article-title":"A double-blind study of the effectiveness and specificity of injection therapy in ragweed hay fever","volume":"273","author":"Lowell","year":"1965","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2013.03.019_bib36","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199908123410702","article-title":"Long-term clinical efficacy of grass-pollen immunotherapy","volume":"341","author":"Durham","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2013.03.019_bib37","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM199602223340804","article-title":"Ragweed immunotherapy in adult asthma","volume":"334","author":"Creticos","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2013.03.019_bib38","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2007.02.035","article-title":"Legends in allergy: Philip S. Norman and Lawrence M. Lichtenstein\u2013the Hopkins experience","volume":"119","author":"Creticos","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"1 Suppl","key":"10.1016\/j.jaci.2013.03.019_bibE1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.09.034","article-title":"Allergen immunotherapy: a practice parameter third update","volume":"127","author":"Cox","year":"2011","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674913005071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674913005071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:39:22Z","timestamp":1758789562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674913005071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0091674913005071"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2013.03.019","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718004293.793477484","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718004293.793477554","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2013.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}