{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:38:12Z","timestamp":1791916692554,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.jaci.2013.05.002","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T03:00:51Z","timestamp":1372215651000},"page":"387-392.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":294,"title":["Early regular egg exposure in infants with eczema: A\u00a0randomized controlled trial"],"prefix":"10.1016","volume":"132","author":[{"given":"Debra J.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Makrides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina E.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2013.05.002_bib1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jaci.2011.01.039","article-title":"Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants","volume":"127","author":"Osborne","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.002_bib2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.5694\/j.1326-5377.2007.tb01077.x","article-title":"Paediatric food allergy trends in a community-based specialist allergy practice, 1995-2006","volume":"186","author":"Mullins","year":"2007","journal-title":"Med J Aust"},{"key":"10.1016\/j.jaci.2013.05.002_bib3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1542\/peds.106.2.346","article-title":"Committee on nutrition. Hypoallergenic infant formulas","volume":"106","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2013.05.002_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.mpg.0000304464.60788.bd","article-title":"Complementary feeding: a commentary by the ESPGHAN committee on nutrition","volume":"46","author":"Agostoni","year":"2008","journal-title":"J Pediatr Gastrenterol Nutr"},{"key":"10.1016\/j.jaci.2013.05.002_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1542\/peds.2007-3022","article-title":"Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods and hydrolysed formulas","volume":"121","author":"Greer","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2013.05.002_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-3038.2007.00680.x","article-title":"Dietary prevention of allergic diseases in infants and small children","volume":"19","author":"Host","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2013.05.002_bib7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1399-3038.2008.00718.x","article-title":"The importance of early complementary feeding in the development of oral tolerance: concerns and controversies","volume":"19","author":"Prescott","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2013.05.002_bib8","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1164\/ajrccm.162.supplement_3.15tac7","article-title":"Oral tolerance","volume":"162","author":"Smith","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2013.05.002_bib9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2222.2011.03948.x","article-title":"Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis","volume":"42","author":"Brozek","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2013.05.002_bib10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1056\/NEJMoa1200435","article-title":"Oral immunotherapy for treatment of egg allergy in children","volume":"367","author":"Burks","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2013.05.002_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/adc.2008.140418","article-title":"Early introduction of fish decreases the risk of eczema in infants","volume":"94","author":"Alm","year":"2009","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2013.05.002_bib12","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jpeds.2007.05.018","article-title":"Solid food introduction in relation to eczema: results from a four-year prospective birth cohort study","volume":"151","author":"Filipiak","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2013.05.002_bib13","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1111\/j.1651-2227.2010.01939.x","article-title":"Early fish introduction is associated with less eczema, but not sensitization, in infants","volume":"99","author":"Hesselmar","year":"2010","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jaci.2013.05.002_bib14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1398-9995.2006.01115.x","article-title":"Fish consumption during the first year of life and development of allergic diseases during childhood","volume":"61","author":"Kull","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2013.05.002_bib15","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1542\/peds.2007-1651","article-title":"Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study","volume":"122","author":"Snijders","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2013.05.002_bib16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1017\/S0007114509991541","article-title":"Early introduction of oats associated with decreased risk of persistent asthma and early introduction of fish with decreased risk of allergic rhinitis","volume":"103","author":"Virtanen","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jaci.2013.05.002_bib17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/adc.2002.025353","article-title":"The introduction of solids in relation to asthma and eczema","volume":"89","author":"Zutavern","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2013.05.002_bib18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jaci.2010.07.028","article-title":"Can early introduction of egg prevent egg allergy in infants? A\u00a0population-based study","volume":"126","author":"Koplin","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.002_bib19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2222.2007.02861.x","article-title":"Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study","volume":"38","author":"Hill","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2013.05.002_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000245677","article-title":"Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis","volume":"195","author":"Kunz","year":"1997","journal-title":"Dermatology"},{"key":"10.1016\/j.jaci.2013.05.002_bib21","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1046\/j.1365-2745.2002.01454.x","article-title":"High incidence of adverse reactions to egg challenge on first known exposure in young atopic dermatitis children: predictive value of skin prick test and radioallergosorbent test to egg proteins","volume":"32","author":"Monti","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2013.05.002_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1398-9995.2011.02737.x","article-title":"T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy","volume":"67","author":"Martino","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2013.05.002_bib23","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.jaci.2008.03.025","article-title":"Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo\/-) regulatory T cell function","volume":"121","author":"Smith","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.002_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1159\/000250441","article-title":"Oral challenge with pasteurized egg white from Gallus domesticus","volume":"151","author":"Jurado-Palomo","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2013.05.002_bibE1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jaci.2011.11.053","article-title":"Significance of ovomucoid- and ovalbumin-specific IgE\/IgG(4) ratios in egg allergy","volume":"129","author":"Caubet","year":"2012","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674913007628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674913007628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:41:18Z","timestamp":1758789678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674913007628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0091674913007628"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2013.05.002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718025117.793481913","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718025117.793482798","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718025117.793524810","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early regular egg exposure in infants with eczema: A\u00a0randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2013.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}