{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:47:44Z","timestamp":1771505264913,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01-AI50989"],"award-info":[{"award-number":["P01-AI50989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI47737"],"award-info":[{"award-number":["R01-AI47737"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004352","name":"DuPont","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.jaci.2013.05.008","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T08:52:27Z","timestamp":1372150347000},"page":"856-865.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"title":["Prominent role of IFN-\u03b3 in patients with aspirin-exacerbated respiratory disease"],"prefix":"10.1016","volume":"132","author":[{"given":"John W.","family":"Steinke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Huyett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Negri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer C.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Borish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2013.05.008_bib1","first-page":"171","article-title":"Molecular mechanisms in aspirin-induced asthma","volume":"12\/4","author":"Szczeklik","year":"2000","journal-title":"ACI Int"},{"key":"10.1016\/j.jaci.2013.05.008_bib2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/thorax.57.7.569","article-title":"The prevalence of aspirin intolerant asthma (AIA) in Australian asthmatic patients","volume":"57","author":"Vally","year":"2002","journal-title":"Thorax"},{"issue":"suppl","key":"10.1016\/j.jaci.2013.05.008_bib3","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1136\/thorax.55.suppl_2.S42","article-title":"Clinical features and diagnosis of aspirin induced asthma","volume":"55","author":"Szczeklik","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2013.05.008_bib4","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/lary.21969","article-title":"Evidence for distinct histologic profile of nasal polyps with and without eosinophilia","volume":"121","author":"Payne","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2013.05.008_bib5","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1067\/mai.2003.67","article-title":"Cytseinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma","volume":"111","author":"Steinke","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib6","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0091-6749(97)80019-X","article-title":"IL-5 synthesis is upregulated in human nasal polyp tissue","volume":"99","author":"Bachert","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib7","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.jaci.2005.02.029","article-title":"Prostaglandin, leukotiene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis","volume":"115","author":"Perez-Novo","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI620","article-title":"Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma","volume":"101","author":"Cowburn","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2013.05.008_bib9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1025","article-title":"Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects","volume":"143","author":"Christie","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2013.05.008_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1164\/ajrccm\/140.1.148","article-title":"Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma","volume":"140","author":"Arm","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2013.05.008_bib11","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1056\/NEJMoa013508","article-title":"Leukotriene-receptor expression on nasal mucosal inflammatory cells in asprin-sensitive rhinosinusitis","volume":"347","author":"Sousa","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2013.05.008_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jaci.2004.10.051","article-title":"Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis","volume":"115","author":"Corrigan","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib13","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/ajrccm.157.4.9707089","article-title":"Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics","volume":"157","author":"Dahlen","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2013.05.008_bib14","first-page":"130","article-title":"Nasal polyposis\u2014a new concept on the formation of polyps","volume":"11","author":"Bachert","year":"1999","journal-title":"ACI Int"},{"key":"10.1016\/j.jaci.2013.05.008_bib15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1165\/ajrcmb.17.6.2865","article-title":"Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis","volume":"17","author":"Minshall","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2013.05.008_bib16","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1046\/j.1365-2222.1998.00380.x","article-title":"GM-CSF, IL-5, and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis","volume":"28","author":"Hamilos","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2013.05.008_bib17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0194-5998(98)70273-6","article-title":"Comparison of inflammatory cell profile and Th2 cytokine expression in the ethmoid sinuses, maxillary sinuses, and turbinates of atopic subjects with chronic sinusitis","volume":"18","author":"Kamil","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2013.05.008_bib18","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/j.1365-2222.2005.02316.x","article-title":"Nasal biomarker profiles in acute and chronic rhinosinusitis","volume":"35","author":"Riechelmann","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2013.05.008_bib19","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.jaci.2008.02.018","article-title":"T-cell regulation in chronic paranasal sinus disease","volume":"121","author":"Van Bruaene","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib20","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1165\/rcmb.2006-0252OC","article-title":"Concordant modulation of cysteinyl leukotriene receptor expression by IL-4 and IFN-\u03b3 on peripheral immune cells","volume":"36","author":"Early","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2013.05.008_bib21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2500\/ajr.2008.22.3233","article-title":"Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps","volume":"22","author":"Payne","year":"2008","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2013.05.008_bib22","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s10875-011-9589-4","article-title":"Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression","volume":"31","author":"Hudson","year":"2011","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0091-6749(95)70298-9","article-title":"Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis","volume":"96","author":"Hamilos","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1189\/jlb.0108058","article-title":"Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially","volume":"85","author":"Spencer","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2013.05.008_bib25","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1182\/blood-2009-12-261339","article-title":"Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma","volume":"116","author":"de Bruin","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2013.05.008_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.182.1.49","article-title":"Differentiation in\u00a0vitro of hybrid eosinophil\/basophile granulocytes: autocrine function of an eosinophil intermediate","volume":"182","author":"Boyce","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2013.05.008_bib27","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S1081-1206(10)62084-4","article-title":"The natural history and clinical characteristics of aspirin-exacerbated respiratory disease","volume":"89","author":"Berges-Gimeno","year":"2002","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib28","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1067\/mai.2002.122458","article-title":"Chronic sinusitis in severe asthma is related to sputum eosinophilia","volume":"109","author":"ten Brinke","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib29","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jaci.2005.08.035","article-title":"Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma","volume":"116","author":"Mascia","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbrc.2005.09.052","article-title":"Identification of endogenous surrogate ligands for human P2Y12 receptors by in silico and in\u00a0vitro methods","volume":"337","author":"Nonaka","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2013.05.008_bib31","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1084\/jem.20091240","article-title":"Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor","volume":"206","author":"Paruchuri","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2013.05.008_bib32","doi-asserted-by":"crossref","first-page":"16695","DOI":"10.1073\/pnas.0808993105","article-title":"Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors","volume":"105","author":"Maekawa","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2013.05.008_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000323433","article-title":"Eosinophils: offenders or general bystanders in allergic airway disease and pulmonary immunity?","volume":"3","author":"Akuthota","year":"2011","journal-title":"J Innate Immun"},{"key":"10.1016\/j.jaci.2013.05.008_bib34","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1073\/pnas.0508946103","article-title":"Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion","volume":"103","author":"Spencer","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2013.05.008_bib35","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.2104","article-title":"Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161","volume":"12","author":"Mjosberg","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib36","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4049\/jimmunol.1101270","article-title":"Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity","volume":"188","author":"Ikutani","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jaci.2009.04.031","article-title":"Eosinophil-derived IFN-\u03b3 induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes","volume":"124","author":"Kanda","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib38","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van Zele","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2013.05.008_bib39","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2500\/aap.2007.28.3052","article-title":"Cytokine expression in peripheral blood lymphocytes before and after aspirin desensitization in aspirin-exacerbated respiratory disease","volume":"28","author":"Shome","year":"2007","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaci.2013.05.008_bib40","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/path.1979","article-title":"Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma","volume":"209","author":"Adamjee","year":"2006","journal-title":"J Pathol"},{"key":"10.1016\/j.jaci.2013.05.008_bib41","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.4049\/jimmunol.181.7.5045","article-title":"IFN consensus sequence binding protein (Icsbp) is critical for eosinophil development","volume":"181","author":"Milanovic","year":"2008","journal-title":"J Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2013.05.008_bib42","doi-asserted-by":"crossref","first-page":"S242","DOI":"10.1067\/mai.2000.110156","article-title":"Systemic aspects of allergic disease: bone marrow responses","volume":"106","author":"Denburg","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.05.008_bib43","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1165\/ajrcmb.20.3.3060","article-title":"Immunolocalization of CD34 in nasal polyp. Effect of topical corticosteroids","volume":"20","author":"Kim","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"suppl","key":"10.1016\/j.jaci.2013.05.008_bib44","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1136\/thorax.55.suppl_2.S24","article-title":"Haemopoietic mechanisms in nasal polyposis and asthma","volume":"55","author":"Denburg","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2013.05.008_bib45","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1378\/chest.128.5.3148","article-title":"Interferon-gamma up-regulates expression of cysteinyl leukotriene type 2 receptors on eosinophils in asthmatic patients","volume":"128","author":"Fujii","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2013.05.008_bib46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1084\/jem.193.1.123","article-title":"T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C4 synthase expression by interleukin 4","volume":"193","author":"Hsieh","year":"2001","journal-title":"J Exp Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674913007707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674913007707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:43:47Z","timestamp":1758789827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674913007707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0091674913007707"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2013.05.008","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prominent role of IFN-\u03b3 in patients with aspirin-exacerbated respiratory disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2013.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}