{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:00:36Z","timestamp":1791172836587,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.jaci.2013.08.009","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T12:30:19Z","timestamp":1377865819000},"page":"1295-1302.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":257,"title":["Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma"],"prefix":"10.1016","volume":"132","author":[{"given":"Michael E.","family":"Wechsler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Laviolette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalberto S.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussara","family":"Fiterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Lapa e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallav L.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Fiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Olivenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil C.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Niven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Pavord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Simoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff B.","family":"Hales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk-Jan","family":"Slebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil C.","family":"Erzurum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola A.","family":"Hanania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaharu","family":"Sumino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Sterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Hogarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel N.","family":"Kline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel H.","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Louie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Leeds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Barbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.M.","family":"Austin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narinder S.","family":"Shargill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Quiring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2013.08.009_bib1","unstructured":"National Health Interview Survey, National Center for Health Statistics, CDC, 2009. Available at: http:\/\/www.cdc.gov\/nchs\/fastats\/asthma.htm. Accessed December 10, 2010."},{"key":"10.1016\/j.jaci.2013.08.009_bib2","unstructured":"American Lung Association, Epidemiology & Statistics Unit, Research and Program Services. Trends in asthma morbidity and mortality, September 2012.\u00a0Available at: http:\/\/www.lung.org\/finding-cures\/our-research\/trend-reports\/asthma-trend-report.pdf. Accessed August 25, 2013."},{"key":"10.1016\/j.jaci.2013.08.009_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jaci.2006.11.639","article-title":"Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program","volume":"119","author":"Moore","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2013.08.009_bib4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s13665-012-0025-x","article-title":"Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort","volume":"1","author":"Chipps","year":"2012","journal-title":"Curr Respir Care Rep"},{"key":"10.1016\/j.jaci.2013.08.009_bib5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/rccm.200704-571OC","article-title":"Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma","volume":"176","author":"Pavord","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2013.08.009_bib6","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1056\/NEJMoa064707","article-title":"Asthma control during the year after bronchial thermoplasty","volume":"356","author":"Cox","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2013.08.009_bib7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1164\/rccm.200903-0354OC","article-title":"Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial","volume":"181","author":"Castro","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2013.08.009_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2466-11-8","article-title":"Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial","volume":"11","author":"Thomson","year":"2011","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jaci.2013.08.009_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.anai.2011.03.005","article-title":"Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma","volume":"107","author":"Castro","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2013.08.009_bib10","unstructured":"World Medical Association Declaration of Helsinki, as most recently amended by the 52nd Annual WMA General Assembly, Edinburgh, Scotland, October 2000, and the note of clarification on Paragraph 29 added by the WMA General Assembly, Washington, DC, 2002, and the note of clarification on Paragraph 30 added by the WMA General Assembly, Tokyo, 2004. Available at: http:\/\/www.wma.net\/en\/30publications\/10policies\/b3\/index.html.pdf?print-media-type&footer-right=[page]\/[toPage]. Accessed August 25, 2013."},{"key":"10.1016\/j.jaci.2013.08.009_bib11","unstructured":"World Medical Association Declaration of Helsinki\u2014ethical principles for medical\u00a0research involving human subjects. Amended by: 59th WMA General\u00a0Assembly;\u00a0Seoul,\u00a0Korea; October 2008. Avaiable at: http:\/\/www.wma.net\/en\/30publications\/10policies\/b3\/index.html.pdf?print-media-type&footer-right=[page]\/[toPage]. Accessed August 25, 2013."},{"key":"10.1016\/j.jaci.2013.08.009_bib12","first-page":"A567","article-title":"Long-term follow-up of bronchial thermoplasty for asthma: safety results at 5 years","volume":"177","author":"Cox","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2013.08.009_bib13","first-page":"A2780","article-title":"Long term safety of bronchial thermoplasty (BT): 3 year data from multiple studies","volume":"179","author":"Cox","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2013.08.009_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.anai.2013.05.002","article-title":"Safety of bronchial thermoplasty in patients with severe refractory asthma","author":"Pavord","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2013.08.009_bib15","series-title":"Expert panel report 3: guidelines for the diagnosis and management of asthma","author":"National Asthma Education and Prevention Program","year":"2007"},{"key":"10.1016\/j.jaci.2013.08.009_bib16","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/S0012-3692(15)31431-8","article-title":"High-resolution CT findings in patients with near-fatal asthma: comparison of patients with mild-to-severe asthma and normal control subjects and changes in airway abnormalities following steroid treatment","volume":"126","author":"Lee","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2013.08.009_bib17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1152\/japplphysiol.00329.2007","article-title":"Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation","volume":"104","author":"Sorkness","year":"2008","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jaci.2013.08.009_bib18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1378\/chest.08-0049","article-title":"A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis","volume":"135","author":"Busacker","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2013.08.009_bib19","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1378\/chest.09-0174","article-title":"Qualitative analysis of high-resolution CT scans in severe asthma","volume":"136","author":"Gupta","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2013.08.009_bib20","first-page":"206","article-title":"Asthma-specific quality of life and subsequent asthma emergency hospital care","volume":"14","author":"Schatz","year":"2008","journal-title":"Am J Manag Care"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674913012682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674913012682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:42:56Z","timestamp":1758789776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674913012682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0091674913012682"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2013.08.009","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2013.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}