{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:04:55Z","timestamp":1761807895384,"version":"3.44.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.jaci.2014.02.043","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T13:45:11Z","timestamp":1400161511000},"page":"411-419.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of somatic hypermutations in the IgM switch region in human B cells"],"prefix":"10.1016","volume":"134","author":[{"given":"Katsuyuki","family":"Horiuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohsuke","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Mitsui-Sekinaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Wen","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans D.","family":"Ochs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Durandy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Nonoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2014.02.043_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)00079-9","article-title":"Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)","volume":"102","author":"Revy","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2014.02.043_bib2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/ni974","article-title":"Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination","volume":"4","author":"Imai","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2014.02.043_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0105-2896.2005.00222.x","article-title":"Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects","volume":"203","author":"Durandy","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2014.02.043_bib4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nature06020","article-title":"IgH class switching and translocations use a robust non-classical end-joining pathway","volume":"449","author":"Yan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2014.02.043_bib5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nri1395","article-title":"Class-switch recombination: interplay of transcription, DNA deamination and DNA repair","volume":"4","author":"Chaudhuri","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2014.02.043_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1084\/jem.20012144","article-title":"Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation","volume":"195","author":"Nagaoka","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib7","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1084\/jem.20022190","article-title":"Mlh1 can function in antibody class switch recombination independently of Msh2","volume":"197","author":"Schrader","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.immunol.26.021607.090236","article-title":"The\u00a0biochemistry of somatic hypermutation","volume":"26","author":"Peled","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2014.02.043_bib9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class\u00a0switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2014.02.043_bib10","doi-asserted-by":"crossref","first-page":"22225","DOI":"10.1073\/pnas.1012591108","article-title":"Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair","volume":"107","author":"Kracker","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.02.043_bib11","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1084\/jem.20061067","article-title":"The in\u00a0vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-\/- ung-\/- mice","volume":"203","author":"Xue","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib12","first-page":"41","article-title":"Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase","volume":"50","author":"Zhu","year":"2003","journal-title":"J Med Dent Sci"},{"key":"10.1016\/j.jaci.2014.02.043_bib13","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.4049\/jimmunol.171.9.4621","article-title":"CD40 stimulation of human peripheral B lymphocytes: distinct response from naive and memory cells","volume":"171","author":"Fecteau","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.02.043_bib14","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1084\/jem.178.3.1097","article-title":"B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells","volume":"178","author":"Nonoyama","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib15","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1182\/blood.V99.5.1544","article-title":"Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease","volume":"99","author":"Warnatz","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.02.043_bib16","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.1128\/MCB.00702-07","article-title":"Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region","volume":"27","author":"Huang","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2014.02.043_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nri1553","article-title":"Somatic hypermutation at A\u00b7T pairs: polymerase error versus dUTP incorporation","volume":"5","author":"Neuberger","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2014.02.043_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1084\/jem.20031831","article-title":"DNA polymerase is involved in hypermutation occurring during immunoglobulin class switch recombination","volume":"199","author":"Faili","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molcel.2004.10.011","article-title":"Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A\/T-focused phase of somatic mutation","volume":"16","author":"Rada","year":"2004","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2014.02.043_bib20","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1126\/science.1145065","article-title":"Strand-biased spreading of mutations during somatic hypermutation","volume":"317","author":"Unniraman","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jaci.2014.02.043_bib21","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1084\/jem.20112253","article-title":"UNG shapes the specificity of AID-induced somatic hypermutation","volume":"209","author":"Perez-Duran","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib22","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nature02821","article-title":"Replication protein A\u00a0interacts with AID to promote deamination of somatic hypermutation targets","volume":"430","author":"Chaudhuri","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2014.02.043_bib23","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1084\/jem.20050042","article-title":"B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil","volume":"201","author":"Kavli","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib24","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1084\/jem.20111531","article-title":"The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination","volume":"209","author":"Chahwan","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib25","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1084\/jem.20080789","article-title":"Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination","volume":"205","author":"P\u00e9ron","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib26","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.4049\/jimmunol.1102984","article-title":"Human MSH6 deficiency is associated with impaired antibody maturation","volume":"188","author":"Gard\u00ebs","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.02.043_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1084\/jem.20062131","article-title":"DNA polymerase eta is the sole contributor of A\/T modifications during immunoglobulin gene hypermutation in the mouse","volume":"204","author":"Delbos","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.02.043_bib28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1172\/JCI18161","article-title":"Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination","volume":"112","author":"Imai","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2014.02.043_bib29","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1084\/jem.20070087","article-title":"A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair","volume":"204","author":"P\u00e9ron","year":"2007","journal-title":"J Exp Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674914005673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674914005673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:48:36Z","timestamp":1758790116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674914005673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0091674914005673"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2014.02.043","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of somatic hypermutations in the IgM switch region in human B cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2014.02.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}