{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:43:04Z","timestamp":1790106184343,"version":"4.0.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.jaci.2014.03.036","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T19:46:11Z","timestamp":1400010371000},"page":"688-697.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Human IgE+ B cells are derived from T cell\u2013dependent and T cell\u2013independent pathways"],"prefix":"10.1016","volume":"134","author":[{"given":"Magdalena A.","family":"Berkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorn J.","family":"Heeringa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enes","family":"Hajdarbegovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"van der Burg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bing","family":"Thio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Martin","family":"van Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques J.M.","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno C.","family":"van Zelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2014.03.036_bib1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nri1958","article-title":"The increase in the prevalence of asthma and allergy: food for thought","volume":"6","author":"Devereux","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"32","key":"10.1016\/j.jaci.2014.03.036_bib2","first-page":"1","article-title":"Asthma prevalence, health care use, and mortality: United States, 2005-2009","author":"Akinbami","year":"2011","journal-title":"Natl Health Stat Report"},{"key":"10.1016\/j.jaci.2014.03.036_bib3","unstructured":"Pawankar R, Canonica G, Holgate S, Lockey R. WAO white book on allergy 2011-2012: executive summary. Milwaukee, WI: World Allergy Organization;2011."},{"key":"10.1016\/j.jaci.2014.03.036_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12016-007-8034-1","article-title":"Food allergy overview in children","volume":"34","author":"Ramesh","year":"2008","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib5","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.jaci.2012.12.1569","article-title":"The enigma of IgE+ B-cell memory in human subjects","volume":"131","author":"Davies","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2014.03.036_bib6","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jaci.2009.11.017","article-title":"IgE, mast cells, basophils, and eosinophils","volume":"125","author":"Stone","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib7","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1002\/eji.200535495","article-title":"Inefficient processing of mRNA for the membrane form of IgE is a genetic mechanism to limit recruitment of IgE-secreting cells","volume":"36","author":"Karnowski","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2249.2010.04210.x","article-title":"CD23\/FcepsilonRII: molecular multi-tasking","volume":"162","author":"Acharya","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nri1181","article-title":"The regulation of immunoglobulin E class-switch recombination","volume":"3","author":"Geha","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib10","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1073\/pnas.90.8.3730","article-title":"Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells","volume":"90","author":"Punnonen","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.03.036_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.humimm.2008.10.021","article-title":"Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings concomitantly with activation-induced cytidine deaminase expression and differentiation into plasma cells","volume":"70","author":"Kobayashi","year":"2009","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1084\/jem.172.2.463","article-title":"Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production","volume":"172","author":"Gauchat","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.03.036_bib13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.20050811","article-title":"The structure of human CD23 and its interactions with IgE and CD21","volume":"202","author":"Hibbert","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.03.036_bib14","doi-asserted-by":"crossref","first-page":"15613","DOI":"10.1074\/jbc.272.25.15613","article-title":"CD86 (B7-2) on human B cells. A\u00a0functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells","volume":"272","author":"Jeannin","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2014.03.036_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jaci.2006.09.045","article-title":"Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma","volume":"119","author":"Takhar","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/35098100","article-title":"In situ class switching and differentiation to IgA-producing cells in the gut lamina propria","volume":"413","author":"Fagarasan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2014.03.036_bib17","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2007.04.014","article-title":"Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL","volume":"26","author":"He","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2014.03.036_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.immuni.2006.12.006","article-title":"Unique maturation program of the IgE response in\u00a0vivo","volume":"26","author":"Erazo","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2014.03.036_bib19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.immuni.2012.02.009","article-title":"Fluorescent in\u00a0vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition","volume":"36","author":"Yang","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2014.03.036_bib20","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1084\/jem.20111155","article-title":"Immature B cells preferentially switch to IgE with increased direct Smu to Sepsilon recombination","volume":"208","author":"Wesemann","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.03.036_bib21","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1084\/jem.179.6.2023","article-title":"Frequency of immunoglobulin E class switching is autonomously determined and independent of prior switching to other classes","volume":"179","author":"Jung","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.03.036_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1084\/jem.20111941","article-title":"Sequential class switching is required for the generation of high affinity IgE antibodies","volume":"209","author":"Xiong","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.03.036_bib23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ni.2256","article-title":"IgE(+) memory B cells and plasma cells generated through a germinal-center pathway","volume":"13","author":"Talay","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib24","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ni.2313","article-title":"On the differentiation of mouse IgE(+) cells","volume":"13","author":"Lafaille","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib25","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1182\/blood-2011-04-345579","article-title":"Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways","volume":"118","author":"Berkowska","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.03.036_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis","volume":"92","author":"Hanifin","year":"1980","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2014.03.036_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1084\/jem.20060964","article-title":"Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion","volume":"204","author":"van Zelm","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.03.036_bib28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jim.2007.09.017","article-title":"Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning","volume":"329","author":"Tiller","year":"2008","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2014.03.036_bib29","doi-asserted-by":"crossref","first-page":"D1006","DOI":"10.1093\/nar\/gkn838","article-title":"IMGT, the international ImMunoGeneTics information system","volume":"37","author":"Lefranc","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2014.03.036_bib30","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1182\/blood-2008-10-183632","article-title":"Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting","volume":"113","author":"Longo","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.03.036_bib31","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1073\/pnas.88.17.7528","article-title":"Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells","volume":"88","author":"Shapira","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.03.036_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1084\/jem.175.1.289","article-title":"Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen","volume":"175","author":"Shapira","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.03.036_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.11.015","article-title":"Human CD19 and CD40L deficiencies impair antibody selection and differentially affect somatic hypermutation","author":"van Zelm","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib34","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1182\/blood-2009-09-243071","article-title":"Complement receptor 2\/CD21- human naive B cells contain mostly autoreactive unresponsive clones","volume":"115","author":"Isnardi","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.03.036_bib35","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1084\/jem.164.5.1455","article-title":"Fc\u00a0epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching","volume":"164","author":"Kikutani","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.03.036_bib36","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1182\/blood-2004-01-0346","article-title":"Human blood IgM \u201cmemory\u201d B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire","volume":"104","author":"Weller","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.03.036_bib37","doi-asserted-by":"crossref","first-page":"890","DOI":"10.4049\/jimmunol.182.2.890","article-title":"Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells","volume":"182","author":"Good","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib38","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.4049\/jimmunol.175.12.7867","article-title":"IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells","volume":"175","author":"Ettinger","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib39","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1067\/mai.2003.1595","article-title":"Allergic and nonallergic forms of atopic diseases","volume":"112","author":"Novak","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib40","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4049\/jimmunol.115.4.982","article-title":"Studies of surface immunoglobulins on human B lymphocytes. I. Dissociation of cell-bound immunoglobulins with acid pH or at 37 degrees C","volume":"115","author":"Kumagai","year":"1975","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib41","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1182\/blood.V99.6.2154","article-title":"The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression","volume":"99","author":"Medina","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.03.036_bib42","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3324\/haematol.2009.018689","article-title":"Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138- and CD138+ plasma cells","volume":"95","author":"Caraux","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.jaci.2014.03.036_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/cimm.1996.1065","article-title":"IgE memory B cells identified by the polymerase chain reaction","volume":"176","author":"Takahama","year":"1997","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000096439","article-title":"Antigens drive memory IgE responses in human allergy via the nasal mucosa","volume":"142","author":"Niederberger","year":"2007","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib45","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0091-6749(95)70321-7","article-title":"IgE+ cells in the peripheral blood of atopic, nonatopic, and bee venom-hypersensitive individuals exhibit the phenotype of highly differentiated B cells","volume":"95","author":"Donohoe","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib46","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jaci.2011.10.029","article-title":"The who, where, and when of IgE in allergic airway disease","volume":"129","author":"Dullaers","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib47","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/eji.1830270835","article-title":"B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production","volume":"27","author":"Agematsu","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib48","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.4049\/jimmunol.177.6.3728","article-title":"A new memory CD27-IgG+ B cell population in peripheral blood expressing VH genes with low frequency of somatic mutation","volume":"177","author":"Fecteau","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib49","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fimmu.2011.00081","article-title":"The relationship between CD27 negative and positive B cell populations in human peripheral blood","volume":"2","author":"Wu","year":"2011","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib50","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1067\/mai.2001.114339","article-title":"Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma","volume":"107","author":"Ying","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib51","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.4049\/jimmunol.174.8.5024","article-title":"Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis","volume":"174","author":"Takhar","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib52","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0091-6749(98)70244-1","article-title":"Expression of IL-4, Cepsilon RNA, and Iepsilon RNA in the nasal mucosa of patients with seasonal rhinitis: effect of topical corticosteroids","volume":"101","author":"Cameron","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib53","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0091-6749(97)70028-9","article-title":"Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma","volume":"99","author":"Humbert","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib54","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ni829","article-title":"DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL","volume":"3","author":"Litinskiy","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2014.03.036_bib55","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.immuni.2006.01.013","article-title":"Natural IgE production in the absence of MHC class II cognate help","volume":"24","author":"McCoy","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2014.03.036_bib56","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1365-2125.2011.03962.x","article-title":"Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE","volume":"72","author":"Lowe","year":"2011","journal-title":"Br J Clin Pharmacol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674914005181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674914005181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:46:29Z","timestamp":1758789989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674914005181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0091674914005181"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2014.03.036","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human IgE+ B cells are derived from T cell\u2013dependent and T cell\u2013independent pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2014.03.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}