{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:54:18Z","timestamp":1789977258653,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.jaci.2014.07.038","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T09:27:59Z","timestamp":1409909279000},"page":"1282-1292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Impairment of cilia architecture and ciliogenesis in hyperplastic nasal epithelium from nasal polyps"],"prefix":"10.1016","volume":"134","author":[{"given":"Ying Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew Shuen","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng Gang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Min","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.jaci.2014.07.038_bib1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","author":"Fokkens","year":"2012","journal-title":"Rhinol Suppl"},{"key":"10.1016\/j.jaci.2014.07.038_bib2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1398-9995.2012.02811.x","article-title":"Expression profiles of regulatory and helper T-cell-associated genes in nasal polyposis","volume":"67","author":"Li","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2014.07.038_bib3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/MOO.0b013e32835f80a0","article-title":"Nasal epithelial repair and remodeling in physical injury, infection, and inflammatory diseases","volume":"21","author":"Yan","year":"2013","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2014.07.038_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11882-012-0328-6","article-title":"Gene expression signatures: a new approach to understanding the pathophysiology of chronic rhinosinusitis","volume":"13","author":"Li","year":"2013","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2014.07.038_bib5","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jaci.2013.01.028","article-title":"Genetics of chronic rhinosinusitis: state of the field and directions forward","volume":"131","author":"Hsu","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.07.038_bib6","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/his.12211","article-title":"Down-regulation of EMP1 is associated with epithelial hyperplasia and metaplasia in nasal polyps","volume":"63","author":"Yu","year":"2013","journal-title":"Histopathology"},{"key":"10.1016\/j.jaci.2014.07.038_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0194-5998(98)80005-3","article-title":"Comparison of CT scan and electron microscopic findings on endoscopically harvested middle turbinates","volume":"118","author":"Biedlingmaier","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2014.07.038_bib8","first-page":"1","article-title":"The mucociliary activity of the upper respiratory tract. III. A\u00a0functional and morphological study on human and animal material with special reference to maxillary sinus diseases","volume":"356","author":"Reimer","year":"1978","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.jaci.2014.07.038_bib9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1017\/S0022215100130580","article-title":"Scanning electron microscopy findings of human respiratory cilia in chronic sinusitis and in recurrent respiratory infections","volume":"109","author":"Toskala","year":"1995","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.jaci.2014.07.038_bib10","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jaci.2011.09.001","article-title":"Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis","volume":"128","author":"Lai","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.07.038_bib11","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/ng.263","article-title":"Foxj1 transcription factors are master regulators of the motile ciliogenic program","volume":"40","author":"Yu","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2014.07.038_bib12","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jaci.2010.12.011","article-title":"Role of p63\/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis","volume":"127","author":"Li","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.07.038_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/thx.2008.106096","article-title":"Oral steroids enhance epithelial repair in nasal polyposis via upregulation of the AP-1 gene network","volume":"64","author":"Li","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2014.07.038_bib14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2500\/ajra.2012.26.3794","article-title":"The use of nasal epithelial stem\/progenitor cells to produce functioning ciliated cells in\u00a0vitro","volume":"26","author":"Zhao","year":"2012","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2014.07.038_bib15","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/lary.23320","article-title":"Airway stem cells: review of potential impact on understanding of upper airway diseases","volume":"122","author":"Yu","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2014.07.038_bib16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cell.2011.10.001","article-title":"Distal airway stem cells yield alveoli in\u00a0vitro and during lung regeneration following H1N1 influenza infection","volume":"147","author":"Kumar","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2014.07.038_bib17","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0954-6111(93)90064-7","article-title":"Airway epithelial cells and mediators of inflammation","volume":"87","author":"Devalia","year":"1993","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2014.07.038_bib18","article-title":"Basic image analysis and manipulation in ImageJ","volume":"Chapter 14","author":"Hartig","year":"2013","journal-title":"Curr Protoc Mol Biol"},{"key":"10.1016\/j.jaci.2014.07.038_bib19","doi-asserted-by":"crossref","first-page":"12564","DOI":"10.1073\/pnas.0914191107","article-title":"Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2\/PP2A balance","volume":"107","author":"Burgess","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.07.038_bib20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.devcel.2010.02.013","article-title":"Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis","volume":"18","author":"Gavet","year":"2010","journal-title":"Dev Cell"},{"key":"10.1016\/j.jaci.2014.07.038_bib21","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2500\/ajra.2009.23.3401","article-title":"The effect of myrtol standardized on human nasal ciliary beat frequency and mucociliary transport time","volume":"23","author":"Han","year":"2009","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2014.07.038_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2818.2003.01209.x","article-title":"All-digital image capture and whole-field analysis of ciliary beat frequency","volume":"211","author":"Sisson","year":"2003","journal-title":"J Microsc"},{"key":"10.1016\/j.jaci.2014.07.038_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jaci.2014.07.038_bib24","series-title":"Generalized, linear, and mixed models","author":"McCulloch","year":"2008"},{"key":"10.1016\/j.jaci.2014.07.038_bib25","doi-asserted-by":"crossref","first-page":"e8157","DOI":"10.1371\/journal.pone.0008157","article-title":"Smoking is associated with shortened airway cilia","volume":"4","author":"Leopold","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2014.07.038_bib26","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.diff.2011.11.015","article-title":"Stages of ciliogenesis and regulation of ciliary length","volume":"83","author":"Avasthi","year":"2012","journal-title":"Differentiation"},{"key":"10.1016\/j.jaci.2014.07.038_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1534-5807(02)00258-7","article-title":"CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells","volume":"3","author":"Chen","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.jaci.2014.07.038_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.devcel.2008.07.004","article-title":"CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease","volume":"15","author":"Tsang","year":"2008","journal-title":"Dev Cell"},{"key":"10.1016\/j.jaci.2014.07.038_bib29","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cell.2007.06.027","article-title":"Cep97 and CP110 suppress a cilia assembly program","volume":"130","author":"Spektor","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2014.07.038_bib30","doi-asserted-by":"crossref","first-page":"L650","DOI":"10.1152\/ajplung.00170.2003","article-title":"Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells","volume":"286","author":"You","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2014.07.038_bib31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/bies.200900031","article-title":"The motile cilium in development and disease: emerging new insights","volume":"31","author":"Roy","year":"2009","journal-title":"Bioessays"},{"key":"10.1016\/j.jaci.2014.07.038_bib32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1165\/rcmb.2006-0400OC","article-title":"IL-13 regulates cilia loss and foxj1 expression in human airway epithelium","volume":"37","author":"Gomperts","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2014.07.038_bib33","first-page":"177","article-title":"Contribution of p53, p63, and p73 to the developmental diseases and cancer","volume":"55","author":"Tomkova","year":"2008","journal-title":"Neoplasma"},{"key":"10.1016\/j.jaci.2014.07.038_bib34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1073\/pnas.0812096106","article-title":"TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity","volume":"106","author":"Tomasini","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.07.038_bib35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.gde.2005.04.008","article-title":"Cilia and disease","volume":"15","author":"Eley","year":"2005","journal-title":"Curr Opin Genet Dev"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674914010422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674914010422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:50:57Z","timestamp":1758790257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674914010422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0091674914010422"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2014.07.038","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impairment of cilia architecture and ciliogenesis in hyperplastic nasal epithelium from nasal polyps","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2014.07.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}