{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:32:01Z","timestamp":1792650721947,"version":"4.5.0"},"reference-count":114,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI072265"],"award-info":[{"award-number":["R01 AI072265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL107151"],"award-info":[{"award-number":["P01 HL107151"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["SRA 130701"],"award-info":[{"award-number":["SRA 130701"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["R21 AI103853"],"award-info":[{"award-number":["R21 AI103853"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.jaci.2014.11.031","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T22:08:31Z","timestamp":1421186911000},"page":"598-608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation"],"prefix":"10.1016","volume":"135","author":[{"given":"Bruce S.","family":"Bochner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nives","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2014.11.031_bib1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.addr.2013.05.007","article-title":"Targeting C-type lectin receptors with multivalent carbohydrate ligands","volume":"65","author":"Lepenies","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jaci.2014.11.031_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0076-6879(10)80009-6","article-title":"Engineered carbohydrate-recognition domains for glycoproteomic analysis of cell surface glycosylation and ligands for glycan-binding receptors","volume":"480","author":"Powlesland","year":"2010","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jaci.2014.11.031_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2012.06492.x","article-title":"Glycobiology of immune responses","volume":"1253","author":"Rabinovich","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nchembio.1525","article-title":"Microbial glycan microarrays define key features of host-microbial interactions","volume":"10","author":"Stowell","year":"2014","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jaci.2014.11.031_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.2012.06517.x","article-title":"Multifarious roles of sialic acids in immunity","volume":"1253","author":"Varki","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib6","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nature05816","article-title":"Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins","volume":"446","author":"Varki","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2014.11.031_bib7","doi-asserted-by":"crossref","first-page":"1R","DOI":"10.1093\/glycob\/cwj008","article-title":"Siglecs\u2014the major sub-family of I-type lectins","volume":"16","author":"Varki","year":"2006","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2014.11.031_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nri2056","article-title":"Siglecs and their roles in the immune system","volume":"7","author":"Crocker","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1196\/annals.1443.011","article-title":"Basic and clinical immunology of Siglecs","volume":"1143","author":"von Gunten","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-immunol-020711-075018","article-title":"Siglecs and immune regulation","volume":"30","author":"Pillai","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1749-6632.2011.06362.x","article-title":"Siglecs as sensors of self in innate and adaptive immune responses","volume":"1253","author":"Paulson","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1749-6632.2011.06449.x","article-title":"CD33-related siglecs as potential\u00a0modulators of inflammatory responses","volume":"1253","author":"Crocker","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nri3737","article-title":"Siglec-mediated regulation of immune cell function in disease","volume":"14","author":"Macauley","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jaci.2014.10.057","article-title":"Glycans and glycan binding proteins in immune regulation: a concise introduction to glycobiology for the allergist","volume":"135","author":"Schnaar","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib15","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1074\/jbc.M412378200","article-title":"Glycan array screening reveals a candidate ligand for Siglec-8","volume":"280","author":"Bochner","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2014.11.031_bib16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jaci.2013.05.018","article-title":"Mice deficient in the St3gal3 gene product \u03b12,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation","volume":"133","author":"Kiwamoto","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib17","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1093\/glycob\/cwi097","article-title":"Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6\u2032-sulfo-sialyl Lewis X as a preferred glycan ligand","volume":"15","author":"Tateno","year":"2005","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2014.11.031_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2222.2008.03173.x","article-title":"Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors","volume":"39","author":"Bochner","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2014.11.031_bib19","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/eji.200324723","article-title":"The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils","volume":"34","author":"Zhang","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jaci.2013.03.024","article-title":"Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK\/ERK activation","volume":"132","author":"Kano","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib21","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1182\/blood-2002-10-3058","article-title":"Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis","volume":"101","author":"Nutku","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.11.031_bib22","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.bbrc.2005.08.202","article-title":"Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury","volume":"336","author":"Nutku","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2014.11.031_bib23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1165\/rcmb.2007-0154OC","article-title":"Interleukin-5 priming of human eosinophils alters Siglec-8 mediated apoptosis pathways","volume":"38","author":"Nutku-Bilir","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2014.11.031_bib24","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1182\/blood-2004-10-4112","article-title":"Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment","volume":"106","author":"von Gunten","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.11.031_bib25","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1203\/PDR.0b013e3181b1bc19","article-title":"Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils","volume":"66","author":"Rashmi","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jaci.2014.11.031_bib26","doi-asserted-by":"crossref","first-page":"20370","DOI":"10.1074\/jbc.M114.574624","article-title":"Siglec-E promotes \u03b22-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung","volume":"289","author":"McMillan","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2014.11.031_bib27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jaci.2007.10.004","article-title":"Inhibition of Fc\u03b5RI-dependent mediator release and calcium flux from human mast cells by Siglec-8 engagement","volume":"121","author":"Yokoi","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib28","doi-asserted-by":"crossref","first-page":"e68143","DOI":"10.1371\/journal.pone.0068143","article-title":"Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen","volume":"8","author":"Mao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2014.11.031_bib29","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.4049\/jimmunol.173.11.6841","article-title":"The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells","volume":"173","author":"Avril","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib30","doi-asserted-by":"crossref","first-page":"e45821","DOI":"10.1371\/journal.pone.0045821","article-title":"Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes","volume":"7","author":"Varchetta","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2014.11.031_bib31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pharmthera.2012.06.005","article-title":"Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions","volume":"135","author":"Kiwamoto","year":"2012","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jaci.2014.11.031_bib32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/SHK.0b013e3181a1bc98","article-title":"Different patterns of Siglec-9-mediated neutrophil death responses in septic shock","volume":"32","author":"von Gunten","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.jaci.2014.11.031_bib33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/jpet.109.152439","article-title":"Eosinophil-selective binding and pro-apoptotic effect in\u00a0vitro of a synthetic Siglec-8 ligand, polymeric 6\u2032-sulfated sialyl Lewis X","volume":"330","author":"Hudson","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jaci.2014.11.031_bib34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1165\/rcmb.2010-0007OC","article-title":"Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs","volume":"44","author":"Guo","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2014.11.031_bib35","doi-asserted-by":"crossref","first-page":"26533","DOI":"10.1074\/jbc.M113.485409","article-title":"Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue","volume":"288","author":"Patnode","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2014.11.031_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.12.579","article-title":"Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis","author":"Kiwamoto","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib37","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1182\/blood-2011-07-343566","article-title":"Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow","volume":"118","author":"Zarbock","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.11.031_bib38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.cellbio.042308.113238","article-title":"Rolling cell adhesion","volume":"26","author":"McEver","year":"2010","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jaci.2014.11.031_bib39","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1067\/mai.2000.110813","article-title":"Road signs guiding leukocytes along the inflammation superhighway","volume":"106","author":"Bochner","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib40","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nm1295-1261","article-title":"Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis","volume":"1","author":"Sandrin","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2014.11.031_bib41","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1056\/NEJMoa074943","article-title":"Cetuximab-induced anaphylaxis and IgE specific for galactose-\u03b11,3-galactose","volume":"358","author":"Chung","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2014.11.031_bib42","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jaci.2014.12.1947","article-title":"The alpha gal story: lessons learned from connecting the dots","volume":"135","author":"Steinke","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl","key":"10.1016\/j.jaci.2014.11.031_bib43","doi-asserted-by":"crossref","first-page":"S297","DOI":"10.1016\/j.jaci.2009.08.043","article-title":"Laboratory evaluation of primary immunodeficiencies","volume":"125","author":"Oliveira","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib44","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jaci.2009.03.013","article-title":"Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclass","volume":"123","author":"von Gunten","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib45","doi-asserted-by":"crossref","first-page":"1235681","DOI":"10.1126\/science.1235681","article-title":"Emerging principles for the therapeutic exploitation of glycosylation","volume":"343","author":"Dalziel","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jaci.2014.11.031_bib46","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/glycob\/cwu027","article-title":"Immunization with recombinantly expressed glycan antigens from Schistosoma mansoni induces glycan-specific antibodies against the parasite","volume":"24","author":"Prasanphanich","year":"2014","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2014.11.031_bib47","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/nature05818","article-title":"Exploiting the defensive sugars of HIV-1 for drug and vaccine design","volume":"446","author":"Scanlan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2014.11.031_bib48","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature10373","article-title":"Broad neutralization coverage of HIV by multiple highly potent antibodies","volume":"477","author":"Walker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2014.11.031_bib49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/nyas.12462","article-title":"Continuing challenges in influenza","volume":"1323","author":"Webster","year":"2014","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib50","doi-asserted-by":"crossref","first-page":"e1967","DOI":"10.1371\/journal.pone.0001967","article-title":"Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity","volume":"3","author":"Rempel","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2014.11.031_bib51","doi-asserted-by":"crossref","first-page":"e257","DOI":"10.1371\/journal.pone.0000257","article-title":"Sialoadhesin (CD169) expression in CD14+ cells is upregulated early after HIV-1 infection and increases during disease progression","volume":"2","author":"van der Kuyl","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2014.11.031_bib52","doi-asserted-by":"crossref","first-page":"7475","DOI":"10.1073\/pnas.1201104109","article-title":"HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells","volume":"109","author":"Puryear","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.11.031_bib53","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1172\/JCI45685","article-title":"Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors","volume":"121","author":"Kardava","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2014.11.031_bib54","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cell.2013.01.011","article-title":"Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation","volume":"152","author":"Chen","year":"2013","journal-title":"Cell"},{"issue":"Suppl 2","key":"10.1016\/j.jaci.2014.11.031_bib55","doi-asserted-by":"crossref","first-page":"8939","DOI":"10.1073\/pnas.0914634107","article-title":"Colloquium paper: uniquely human evolution of sialic acid genetics and biology","volume":"107","author":"Varki","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.11.031_bib56","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1182\/blood-2008-11-187302","article-title":"Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response","volume":"113","author":"Carlin","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.11.031_bib57","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/glycob\/cwu067","article-title":"The interplay between Siglecs and sialylated pathogens","volume":"24","author":"Chang","year":"2014","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2014.11.031_bib58","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1007\/s00018-013-1311-7","article-title":"Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation","volume":"70","author":"Angata","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib59","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1084\/jem.20131853","article-title":"Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus","volume":"211","author":"Ali","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.11.031_bib60","doi-asserted-by":"crossref","first-page":"e04066","DOI":"10.7554\/eLife.04066","article-title":"Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1","volume":"3","author":"Chen","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.jaci.2014.11.031_bib61","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1034\/j.1600-065X.2000.17805.x","article-title":"Leukocyte adhesion deficiency II-from A\u00a0to almost Z","volume":"178","author":"Etzioni","year":"2000","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2014.11.031_bib62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bcmd.2011.10.004","article-title":"Hematologically important mutations: leukocyte adhesion deficiency (first update)","volume":"48","author":"van de Vijver","year":"2012","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.jaci.2014.11.031_bib63","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1056\/NEJMoa0901053","article-title":"Human dectin-1 deficiency and mucocutaneous fungal infections","volume":"361","author":"Ferwerda","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2014.11.031_bib64","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1056\/NEJMoa0810719","article-title":"A\u00a0homozygous CARD9 mutation in a family with susceptibility to fungal infections","volume":"361","author":"Glocker","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2014.11.031_bib65","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev.immunol.25.022106.141702","article-title":"The impact of glycosylation on the biological function and structure of human immunoglobulins","volume":"25","author":"Arnold","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib66","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nri3401","article-title":"Intravenous immunoglobulin therapy: how does IgG modulate the immune system?","volume":"13","author":"Schwab","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib67","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri3401-c1","article-title":"IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist","volume":"14","author":"von Gunten","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib68","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/0140-6736(93)92000-J","article-title":"Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura","volume":"342","author":"Debre","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2014.11.031_bib69","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.291.5503.484","article-title":"Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor","volume":"291","author":"Samuelsson","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jaci.2014.11.031_bib70","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1129594","article-title":"Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation","volume":"313","author":"Kaneko","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jaci.2014.11.031_bib71","doi-asserted-by":"crossref","first-page":"19571","DOI":"10.1073\/pnas.0810163105","article-title":"Identification of a receptor required for the anti-inflammatory activity of IVIG","volume":"105","author":"Anthony","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.11.031_bib72","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1016\/j.molimm.2007.02.005","article-title":"Enhanced binding affinity for Fc\u03b3RIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity","volume":"44","author":"Masuda","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib73","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jim.2014.03.021","article-title":"Characterization of in\u00a0vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies\u2014impact of effector cells","volume":"407","author":"Chung","year":"2014","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2014.11.031_bib74","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2010.04.004","article-title":"MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function","volume":"125","author":"Kolbeck","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib75","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1172\/JCI65899","article-title":"Interactions between Siglec-7\/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance","volume":"124","author":"Jandus","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2014.11.031_bib76","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nchembio.1388","article-title":"Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion","volume":"10","author":"Hudak","year":"2014","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jaci.2014.11.031_bib77","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature13535","article-title":"The cancer glycocalyx mechanically primes integrin-mediated growth and survival","volume":"511","author":"Paszek","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2014.11.031_bib78","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1517\/14712598.2012.725719","article-title":"MUC1 immunotherapy is here to stay","volume":"13","author":"Kimura","year":"2013","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jaci.2014.11.031_bib79","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jaci.2014.03.031","article-title":"Siglec-7 is an inhibitory receptor on human mast cells and basophils","volume":"134","author":"Mizrahi","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib80","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1398-9995.2008.01709.x","article-title":"Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils","volume":"63","author":"Zimmermann","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2014.11.031_bib81","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.4049\/jimmunol.0801421","article-title":"Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling","volume":"183","author":"Song","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib82","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MPG.0b013e3182182ff8","article-title":"Siglec-F inhibition reduces esophageal eosinophilia and angiogenesis in a mouse model of eosinophilic esophagitis","volume":"53","author":"Rubinstein","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jaci.2014.11.031_bib83","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clim.2008.11.009","article-title":"Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model","volume":"131","author":"Song","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib84","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1182\/blood-2006-08-039255","article-title":"Defining the in\u00a0vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils","volume":"109","author":"Zhang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.11.031_bib85","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/1465-9921-11-154","article-title":"Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13","volume":"11","author":"Cho","year":"2010","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2014.11.031_bib86","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.4049\/jimmunol.1203455","article-title":"Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice","volume":"190","author":"Suzukawa","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib87","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/ACI.0b013e32835b594a","article-title":"The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation","volume":"13","author":"Kiwamoto","year":"2013","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib88","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/glycob\/cwu068","article-title":"Siglec-G\/10 in self-nonself discrimination of innate and adaptive immunity","volume":"24","author":"Chen","year":"2014","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2014.11.031_bib89","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nrrheum.2014.54","article-title":"The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease","volume":"10","author":"Muller","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jaci.2014.11.031_bib90","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1126\/science.1168988","article-title":"CD24 and Siglec-10 selectively repress tissue damage-induced immune responses","volume":"323","author":"Chen","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jaci.2014.11.031_bib91","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni1480","article-title":"Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population","volume":"8","author":"Hoffmann","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib92","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.4049\/jimmunol.1303367","article-title":"Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL\/lpr mice","volume":"192","author":"Bokers","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib93","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1182\/blood-2013-12-545335","article-title":"Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice","volume":"123","author":"Toubai","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.11.031_bib94","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.4049\/jimmunol.0902711","article-title":"CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity","volume":"184","author":"Jellusova","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib95","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ni.2610","article-title":"T\u00a0cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10","volume":"14","author":"Bandala-Sanchez","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib96","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1136\/ard.2011.153130","article-title":"Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease","volume":"70","author":"Grader-Beck","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2014.11.031_bib97","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1053\/j.gastro.2006.04.030","article-title":"Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease","volume":"131","author":"Dotan","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2014.11.031_bib98","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1191\/0961203306lu2331oa","article-title":"Anti-glycan antibodies as biomarkers for diagnosis and prognosis","volume":"15","author":"Dotan","year":"2006","journal-title":"Lupus"},{"key":"10.1016\/j.jaci.2014.11.031_bib99","doi-asserted-by":"crossref","first-page":"11014","DOI":"10.1002\/anie.201205831","article-title":"Click and pick: identification of sialoside analogues for siglec-based cell targeting","volume":"51","author":"Rillahan","year":"2012","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.jaci.2014.11.031_bib100","doi-asserted-by":"crossref","first-page":"15696","DOI":"10.1021\/ja307501e","article-title":"In silico-aided design of a glycan ligand of sialoadhesin for in\u00a0vivo targeting of macrophages","volume":"134","author":"Nycholat","year":"2012","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jaci.2014.11.031_bib101","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1039\/c4sc00451e","article-title":"Disubstituted sialic acid ligands targeting Siglecs CD33 and CD22 associated\u00a0with myeloid leukaemias and B cell lymphomas","volume":"5","author":"Rillahan","year":"2014","journal-title":"Chem Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib102","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tips.2009.02.005","article-title":"Siglecs as targets for therapy in immune-cell-mediated disease","volume":"30","author":"O'Reilly","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jaci.2014.11.031_bib103","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1073\/pnas.1219888110","article-title":"Targeted delivery of lipid antigen to macrophages via the CD169\/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation","volume":"110","author":"Kawasaki","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.11.031_bib104","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.4049\/jimmunol.1303278","article-title":"Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation","volume":"193","author":"Kawasaki","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib105","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1084\/jem.20091873","article-title":"Decoration of\u00a0T-independent antigen with ligands for CD22 and Siglec-G can suppress\u00a0immunity and induce B cell tolerance in\u00a0vivo","volume":"207","author":"Duong","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2014.11.031_bib106","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1172\/JCI69187","article-title":"Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis","volume":"123","author":"Macauley","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2014.11.031_bib107","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.4049\/jimmunol.1300921","article-title":"Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22","volume":"191","author":"Pfrengle","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib108","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1182\/blood-2006-05-021568","article-title":"Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin preparations","volume":"108","author":"von Gunten","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.11.031_bib109","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.jaci.2007.01.023","article-title":"Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies","volume":"119","author":"von Gunten","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2014.11.031_bib110","doi-asserted-by":"crossref","first-page":"e101301","DOI":"10.1371\/journal.pone.0101301","article-title":"Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia","volume":"9","author":"Wun","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2014.11.031_bib111","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1182\/blood-2009-12-260513","article-title":"GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice","volume":"116","author":"Chang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2014.11.031_bib112","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1073\/pnas.0711271105","article-title":"IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions","volume":"105","author":"Collin","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2014.11.031_bib113","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1002\/art.34454","article-title":"IgG glycan hydrolysis by endoglycosidase S diminishes the proinflammatory properties of immune complexes from patients with systemic lupus erythematosus: a possible new treatment?","volume":"64","author":"Lood","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2014.11.031_bib114","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1073\/pnas.1301480110","article-title":"Dominant suppression of inflammation by glycan-hydrolyzed IgG","volume":"110","author":"Nandakumar","year":"2013","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674914017345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674914017345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:50:39Z","timestamp":1758790239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674914017345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":114,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0091674914017345"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2014.11.031","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2014.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}