{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:39:44Z","timestamp":1780375184651,"version":"3.54.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"am","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_133109"],"award-info":[{"award-number":["310030_133109"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["IG-13176"],"award-info":[{"award-number":["IG-13176"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministry of Education, University and Research","doi-asserted-by":"publisher","award":["PON_03PE_00146_1"],"award-info":[{"award-number":["PON_03PE_00146_1"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004726","name":"Ministry of Health","doi-asserted-by":"publisher","award":["GR-2011-02347781"],"award-info":[{"award-number":["GR-2011-02347781"]}],"id":[{"id":"10.13039\/501100004726","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004462","name":"National Research Council (CNR Flagship Project InterOmics)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"\u201cMario e Valeria Rindi\u201d fellowship of the Italian Foundation for Cancer Research (FIRC)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swiss National Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jaci.2015.05.031","type":"journal-article","created":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T11:35:19Z","timestamp":1436096119000},"page":"58-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Small RNA profiling reveals deregulated phosphatase and tensin homolog (PTEN)\/phosphoinositide 3-kinase (PI3K)\/Akt pathway in bronchial smooth muscle cells from asthmatic patients"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6220-6229","authenticated-orcid":false,"given":"Elena","family":"Alexandrova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Miglino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-8315","authenticated-orcid":false,"given":"Adnan","family":"Hashim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-1240","authenticated-orcid":false,"given":"Giovanni","family":"Nassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Stellato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Baty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Brutsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Weisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Borger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2015.05.031_bib1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ncb2613","article-title":"The functions of\u00a0microRNAs in pluripotency and reprogramming","volume":"14","author":"Leonardo","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2015.05.031_bib2","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1007\/s00018-009-8750-1","article-title":"The role of microRNAs in metastasis and epithelial-mesenchymal transition","volume":"66","author":"Bracken","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jaci.2015.05.031_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/bies.080099","article-title":"RNA regulation of epigenetic processes","volume":"31","author":"Mattick","year":"2009","journal-title":"Bioessays"},{"key":"10.1016\/j.jaci.2015.05.031_bib4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs","volume":"79","author":"Fabian","year":"2010","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jaci.2015.05.031_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2015.05.031_bib6","doi-asserted-by":"crossref","first-page":"D152","DOI":"10.1093\/nar\/gkq1027","article-title":"miRBase: integrating microRNA annotation and deep-sequencing data","volume":"39","author":"Kozomara","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib7","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: annotating high confidence microRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib8","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jaci.2015.05.031_bib9","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1101\/gr.121210.111","article-title":"Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs","volume":"21","author":"Schnall-Levin","year":"2011","journal-title":"Genome Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib10","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2014.06.005","article-title":"MicroRNAs in cancer: biomarkers, functions and therapy","volume":"20","author":"Hayes","year":"2014","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jaci.2015.05.031_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-immunol-020711-075013","article-title":"microRNA regulation of inflammatory responses","volume":"30","author":"O'Connell","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2015.05.031_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/imr.12060","article-title":"Regulation of immune responses and tolerance: the microRNA perspective","volume":"253","author":"Chen","year":"2013","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2015.05.031_bib13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1126\/science.1129333","article-title":"A distinct small RNA pathway silences selfish genetic elements in the germline","volume":"313","author":"Vagin","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jaci.2015.05.031_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature12987","article-title":"PIWI proteins and PIWI-interacting RNAs in the soma","volume":"505","author":"Ross","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2015.05.031_bib15","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/hep.27267","article-title":"Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration","volume":"60","author":"Rizzo","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jaci.2015.05.031_bib16","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.18632\/oncotarget.2476","article-title":"RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer","volume":"5","author":"Hashim","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.jaci.2015.05.031_bib17","doi-asserted-by":"crossref","first-page":"10198","DOI":"10.18632\/oncotarget.2548","article-title":"Signaling pathways activation profiles make better markers of cancer than expression of individual genes","volume":"5","author":"Borisov","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.jaci.2015.05.031_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaci.2013.04.011","article-title":"MicroRNAs: essential players in the regulation of inflammation","volume":"132","author":"Rebane","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.05.031_bib19","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1183\/09031936.00189811","article-title":"Asthma and the regulated retrotransposon transcriptome","volume":"40","author":"Miglino","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2015.05.031_bib20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s11882-014-0424-x","article-title":"MicroRNAs in allergy and asthma","volume":"14","author":"Rebane","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2015.05.031_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1165\/rcmb.2013-0067OC","article-title":"Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma","volume":"50","author":"Perry","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2015.05.031_bib22","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1164\/ajrccm.164.3.2010109","article-title":"Airway smooth muscle cell proliferation is increased in asthma","volume":"164","author":"Johnson","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2015.05.031_bib23","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/1471-2105-14-362","article-title":"iMir: an integrated pipeline for high-throughput analysis of small non-coding RNA data obtained by smallRNA-Seq","volume":"14","author":"Giurato","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jaci.2015.05.031_bib24","doi-asserted-by":"crossref","first-page":"D173","DOI":"10.1093\/nar\/gkm696","article-title":"piRNABank: a web resource on classified and clustered Piwi-interacting RNAs","volume":"36","author":"Sai Lakshmi","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib25","doi-asserted-by":"crossref","first-page":"D226","DOI":"10.1093\/nar\/gks1005","article-title":"Rfam 11.0: 10 years of RNA families","volume":"41","author":"Burge","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib26","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1186\/gb-2009-10-4-r39","article-title":"FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions","volume":"10","author":"Severin","year":"2009","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2015.05.031_bib27","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2015.05.031_bib28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2015.05.031_bib29","doi-asserted-by":"crossref","first-page":"D153","DOI":"10.1093\/nar\/gku1215","article-title":"DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib30","doi-asserted-by":"crossref","first-page":"D105","DOI":"10.1093\/nar\/gkn851","article-title":"miRecords: an integrated resource for microRNA-target interactions","volume":"37","author":"Xiao","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib31","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1186\/gb-2003-5-1-r1","article-title":"MicroRNA targets in Drosophila","volume":"5","author":"Enright","year":"2003","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2015.05.031_bib32","doi-asserted-by":"crossref","first-page":"e89875","DOI":"10.1371\/journal.pone.0089875","article-title":"Hypoxia exerts dualistic effects on inflammatory and proliferative responses of healthy and asthmatic primary human bronchial smooth muscle cells","volume":"9","author":"Keglowich","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2015.05.031_bib33","doi-asserted-by":"crossref","first-page":"e5889","DOI":"10.1371\/journal.pone.0005889","article-title":"MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy","volume":"4","author":"Williams","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2015.05.031_bib34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000358486","article-title":"Altered microRNA expression of nasal mucosa in long-term asthma and allergic rhinitis","volume":"163","author":"Suojalehto","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2015.05.031_bib35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jaci.2013.03.006","article-title":"Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults","volume":"132","author":"Pinkerton","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.05.031_bib36","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1465-9921-11-68","article-title":"Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle","volume":"11","author":"Larner-Svensson","year":"2010","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib37","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1165\/rcmb.2014-0129OC","article-title":"Cyclooxygenase-2 and microrna-155 expression are elevated in asthmatic airway smooth muscle cells","volume":"52","author":"Comer","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2015.05.031_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874306401206010001","article-title":"Asthma and COPD\u2014the C\/EBP connection","volume":"6","author":"Miglino","year":"2012","journal-title":"Open Respir Med J"},{"key":"10.1016\/j.jaci.2015.05.031_bib39","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/cea.12135","article-title":"Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs","volume":"43","author":"Plank","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2015.05.031_bib40","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/nmeth.3014","article-title":"Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study","volume":"11","author":"Mestdagh","year":"2014","journal-title":"Nat Methods"},{"key":"10.1016\/j.jaci.2015.05.031_bib41","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nature09465","article-title":"Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo","volume":"467","author":"Rouget","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2015.05.031_bib42","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/cr.2014.41","article-title":"Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis","volume":"24","author":"Gou","year":"2014","journal-title":"Cell Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib43","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.rmed.2009.01.015","article-title":"Association of peroxisome proliferator-activated receptor-gamma gene polymorphisms with the development of asthma","volume":"103","author":"Oh","year":"2009","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2015.05.031_bib44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.bjp.0705232","article-title":"PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in\u00a0vitro evidence for an NF-kappaB-independent effect","volume":"139","author":"Trifilieff","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2015.05.031_bib45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1465-9921-8-90","article-title":"Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma","volume":"8","author":"Narala","year":"2007","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib46","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1164\/rccm.200709-1363OC","article-title":"ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts","volume":"178","author":"Litonjua","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2015.05.031_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02770900701247319","article-title":"Peroxisome proliferator-activated receptor gamma as a novel therapeutic target in asthma","volume":"45","author":"Park","year":"2008","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2015.05.031_bib48","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.farmac.2005.08.011","article-title":"New 8-substituted xanthiene derivatives as potent bronchodilators","volume":"60","author":"Berk","year":"2005","journal-title":"Farmaco"},{"key":"10.1016\/j.jaci.2015.05.031_bib49","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/sj.bjp.0706272","article-title":"The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma","volume":"145","author":"Holgate","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2015.05.031_bib50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1164\/rccm.200411-1555OC","article-title":"Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations","volume":"172","author":"Weiss","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2015.05.031_bib51","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jaci.2007.03.029","article-title":"Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life","volume":"119","author":"Thompson","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.05.031_bib52","doi-asserted-by":"crossref","first-page":"e56914","DOI":"10.1371\/journal.pone.0056914","article-title":"Genetic variation of ITGB3 is associated with asthma in Chinese Han children","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2015.05.031_bib53","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1164\/rccm.200812-1860OC","article-title":"Assessing the reproducibility of asthma candidate gene associations, using genome-wide data","volume":"179","author":"Rogers","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2015.05.031_bib54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jaci.2011.04.007","article-title":"Mold allergen sensitization in adult asthma according to integrin beta3 polymorphisms and Toll-like receptor 2\/+596 genotype","volume":"128","author":"Smit","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.05.031_bib55","first-page":"106576","article-title":"The molecular genetics and cellular mechanisms underlying pulmonary arterial hypertension","volume":"2012","author":"Machado","year":"2012","journal-title":"Scientifica (Cairo)"},{"key":"10.1016\/j.jaci.2015.05.031_bib56","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/2045-8932.114752","article-title":"Signal transduction in the development of pulmonary arterial hypertension","volume":"3","author":"Malenfant","year":"2013","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jaci.2015.05.031_bib57","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1164\/rccm.200709-1376OC","article-title":"Basal expression of bone morphogenetic protein receptor is reduced in mild asthma","volume":"177","author":"Kariyawasam","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2015.05.031_bib58","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yexmp.2012.04.004","article-title":"Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation","volume":"93","author":"Agrawal","year":"2012","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.jaci.2015.05.031_bib59","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.rmed.2009.06.016","article-title":"PTEN identified as important risk factor of chronic obstructive pulmonary disease","volume":"103","author":"Hosgood","year":"2009","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2015.05.031_bib60","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1465-9921-12-47","article-title":"A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression","volume":"12","author":"Ni","year":"2011","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib61","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1053\/j.gastro.2009.02.002","article-title":"The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim","volume":"136","author":"Kan","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2015.05.031_bib62","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/CIRCRESAHA.109.197491","article-title":"Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17\/92 pathway","volume":"104","author":"Brock","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.jaci.2015.05.031_bib63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-pharmtox-010510-100517","article-title":"microRNAs: master regulators as potential therapeutics in cancer","volume":"51","author":"Garofalo","year":"2011","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jaci.2015.05.031_bib64","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1126\/science.1174381","article-title":"MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice","volume":"324","author":"Bonauer","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jaci.2015.05.031_bib65","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/ncb2615","article-title":"YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29","volume":"14","author":"Tumaneng","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2015.05.031_bib66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ng.858","article-title":"A\u00a0cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)","volume":"43","author":"Mavrakis","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2015.05.031_bib67","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2011.09.032","article-title":"In\u00a0vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma","volume":"147","author":"Karreth","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2015.05.031_bib68","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1096\/fj.13-247247","article-title":"MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway","volume":"28","author":"Hu","year":"2014","journal-title":"FASEB J"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674915007770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674915007770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:55:58Z","timestamp":1758790558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674915007770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0091674915007770"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2015.05.031","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small RNA profiling reveals deregulated phosphatase and tensin homolog (PTEN)\/phosphoinositide 3-kinase (PI3K)\/Akt pathway in bronchial smooth muscle cells from asthmatic patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2015.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}