{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:50:19Z","timestamp":1791298219865,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","award":["R01AI108643"],"award-info":[{"award-number":["R01AI108643"]}],"id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 AI038339"],"award-info":[{"award-number":["RO1 AI038339"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 HL118092"],"award-info":[{"award-number":["RO1 HL118092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK42086"],"award-info":[{"award-number":["P30DK42086"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL118092"],"award-info":[{"award-number":["R01HL118092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI108643"],"award-info":[{"award-number":["AI108643"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI038339"],"award-info":[{"award-number":["R01AI038339"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL007605"],"award-info":[{"award-number":["T32 HL007605"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012848","name":"Digestive Diseases Research Core Center, University of Chicago","doi-asserted-by":"publisher","award":["P30DK42086"],"award-info":[{"award-number":["P30DK42086"]}],"id":[{"id":"10.13039\/100012848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jaci.2015.07.050","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T17:40:16Z","timestamp":1445794816000},"page":"591-600.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)\u2013deficient mice"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1502-5468","authenticated-orcid":false,"given":"Philip A.","family":"Verhoef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Constantinides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Joseph F.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne I.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Bendelac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2015.07.050_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nri3369","article-title":"Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions","volume":"13","author":"Brennan","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells","volume":"25","author":"Bendelac","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/MOG.0b013e328365d339","article-title":"Innate lymphoid cells in homeostasis, infection, chronic inflammation and tumors of the gastrointestinal tract","volume":"29","author":"Fuchs","year":"2013","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jaci.2015.07.050_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nri3384","article-title":"Six-of-the-best: unique contributions of gammadelta T cells to immunology","volume":"13","author":"Vantourout","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib5","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.coi.2013.09.012","article-title":"Commensal microbiota and NKT cells in the control of inflammatory diseases at mucosal surfaces","volume":"25","author":"Zeissig","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.coi.2013.01.003","article-title":"Transcriptional regulation of the NKT cell lineage","volume":"25","author":"Constantinides","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.immuni.2008.07.011","article-title":"The transcription factor PLZF directs the effector program of the NKT cell lineage","volume":"29","author":"Savage","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2015.07.050_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nature13047","article-title":"A committed precursor to innate lymphoid cells","volume":"508","author":"Constantinides","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2015.07.050_bib9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2011.12.020","article-title":"Lung natural helper cells are a critical\u00a0source of Th2 cell-type cytokines in protease allergen-induced airway inflammation","volume":"36","author":"Halim","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2015.07.050_bib10","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2015.07.050_bib11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/ni.2131","article-title":"Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus","volume":"12","author":"Monticelli","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.coi.2012.08.009","article-title":"Type 2 innate lymphoid cells: new players in asthma and allergy","volume":"24","author":"Scanlon","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2014.01.011","article-title":"Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation","volume":"40","author":"Halim","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2015.07.050_bib14","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/all.12446","article-title":"Group 2 innate lymphoid cells and CD4+ T\u00a0cells\u00a0cooperate to mediate type 2 immune response in mice","volume":"69","author":"Drake","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2015.07.050_bib15","first-page":"19.1","article-title":"Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus","volume":"55:chapter 19","author":"Camberis","year":"2003","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib16","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0900591106","article-title":"A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma","volume":"106","author":"Caceres","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2015.07.050_bib17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2014.06.024","article-title":"Enhanced innate type 2 immune response in peripheral blood from patients with asthma","volume":"134","author":"Bartemes","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib18","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1084\/jem.20130071","article-title":"IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation","volume":"210","author":"Turner","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2015.07.050_bib19","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1073\/pnas.1206587110","article-title":"IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms","volume":"110","author":"Hung","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2015.07.050_bib20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.immuni.2012.06.012","article-title":"Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural\u00a0helper cell development and allergic inflammation","volume":"37","author":"Halim","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2015.07.050_bib21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.immuni.2015.02.007","article-title":"ICOS:\u00a0ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity","volume":"42","author":"Maazi","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2015.07.050_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ni.3078","article-title":"IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential \u2018inflammatory\u2019 type 2 innate lymphoid cells","volume":"16","author":"Huang","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2014.11.037","article-title":"Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33","volume":"136","author":"Christianson","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.07.050_bib24","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.immuni.2014.04.013","article-title":"Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation","volume":"40","author":"Motomura","year":"2014","journal-title":"Immunity"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674915013329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674915013329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:58:41Z","timestamp":1758790721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674915013329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0091674915013329"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2015.07.050","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)\u2013deficient mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2015.07.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}