{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:41:48Z","timestamp":1791398508387,"version":"4.3.3"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jaci.2015.09.013","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T09:54:00Z","timestamp":1446630840000},"page":"1206-1215.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency"],"prefix":"10.1016","volume":"137","author":[{"given":"Montserrat","family":"Cols","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeeb","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Maglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Garcia-Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Simchoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-Bin M.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Radigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cerutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Blankenship","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham-Rundles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2015.09.013_bib1","first-page":"162","article-title":"Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency","volume":"5","author":"Al-Herz","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fimmu.2012.00210","article-title":"Pathogenesis of autoimmunity in common variable immunodeficiency","volume":"3","author":"Warnatz","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","article-title":"Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency","volume":"27","author":"Quinti","year":"2007","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2015.09.013_bib5","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","article-title":"Morbidity and mortality in common variable immune deficiency over 4 decades","volume":"119","author":"Resnick","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2015.09.013_bib6","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.4049\/jimmunol.178.6.3932","article-title":"Unravelling the complexity of T cell abnormalities in common variable immunodeficiency","volume":"178","author":"Giovannetti","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib7","doi-asserted-by":"crossref","first-page":"e74893","DOI":"10.1371\/journal.pone.0074893","article-title":"Interferon signature in the blood in inflammatory common variable immune deficiency","volume":"8","author":"Park","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2015.09.013_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells\u2014a proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib9","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1182\/blood-2013-11-427781","article-title":"Human innate lymphoid cells","volume":"124","author":"Hazenberg","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2015.09.013_bib10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.1198704","article-title":"Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum","volume":"332","author":"Bendall","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jaci.2015.09.013_bib11","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ni.2830","article-title":"Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells","volume":"15","author":"Magri","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells","volume":"517","author":"Artis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2015.09.013_bib13","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.1016\/j.febslet.2014.03.034","article-title":"Development and regulation of RORgammat innate lymphoid cells","volume":"588","author":"Cording","year":"2014","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2015.09.013_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1084\/jem.20091509","article-title":"Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells","volume":"207","author":"Crellin","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2015.09.013_bib15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2014.03.030","article-title":"Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages","volume":"157","author":"Klose","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2015.09.013_bib16","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457","author":"Cella","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2015.09.013_bib17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni.2534","article-title":"Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues","volume":"14","author":"Bernink","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0002-9440(10)64378-7","article-title":"Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes","volume":"160","author":"Kunkel","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2015.09.013_bib19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.20091021","article-title":"CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function","volume":"207","author":"Rivino","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2015.09.013_bib20","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nature08949","article-title":"Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology","volume":"464","author":"Buonocore","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2015.09.013_bib21","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/eji.201242639","article-title":"Transcriptional control of innate lymphoid cells","volume":"42","author":"Mjosberg","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nature13047","article-title":"A committed precursor to innate lymphoid cells","volume":"508","author":"Constantinides","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2015.09.013_bib23","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1084\/jem.20101712","article-title":"IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease","volume":"208","author":"Geremia","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2015.09.013_bib24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/ni.2187","article-title":"AHR\u00a0drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch","volume":"13","author":"Lee","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib25","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/annrheumdis-2014-206323","article-title":"Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis","volume":"74","author":"Ciccia","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2015.09.013_bib26","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/jid.2014.146","article-title":"Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients","volume":"134","author":"Teunissen","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2015.09.013_bib27","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.immuni.2014.09.006","article-title":"Innate lymphoid cells in inflammation and immunity","volume":"41","author":"McKenzie","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2015.09.013_bib28","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/00000478-200004000-00015","article-title":"Nodular lymphoid hyperplasia of the lung: a clinicopathologic study of 14 cases","volume":"24","author":"Abbondanzo","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaci.2015.09.013_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1182\/blood-2010-01-254417","article-title":"How I treat common variable immune deficiency","volume":"116","author":"Cunningham-Rundles","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2015.09.013_bib30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s10875-012-9778-9","article-title":"Granulomatous disease in CVID: retrospective analysis of clinical characteristics and treatment efficacy in a cohort of 59 patients","volume":"33","author":"Boursiquot","year":"2013","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib32","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.jaci.2014.11.029","article-title":"Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency","volume":"135","author":"Wehr","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib33","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2141.2011.08880.x","article-title":"Efficacy and safety of rituximab in common variable immunodeficiency-associated immune cytopenias: a retrospective multicentre study on 33 patients","volume":"155","author":"Gobert","year":"2011","journal-title":"Br\u00a0J Haematol"},{"key":"10.1016\/j.jaci.2015.09.013_bib34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10875-012-9755-3","article-title":"Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID)","volume":"33","author":"Chase","year":"2013","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood-2010-11-321695","article-title":"T and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency","volume":"118","author":"Ochtrop","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2015.09.013_bib36","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jaci.2011.02.039","article-title":"Genome-wide association identifies diverse causes of common variable immunodeficiency","volume":"127","author":"Orange","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib37","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s10875-014-0053-0","article-title":"Cytokines in common variable immunodeficiency as signs of immune dysregulation and potential therapeutic targets\u2014a review of the current knowledge","volume":"34","author":"Varzaneh","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib38","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1053\/j.gastro.2006.06.022","article-title":"Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency","volume":"131","author":"Mannon","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2015.09.013_bib39","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jaci.2009.06.018","article-title":"Pathogenesis and treatment of gastrointestinal disease in antibody deficiency syndromes","volume":"124","author":"Agarwal","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib40","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s10875-013-9873-6","article-title":"Nodular regenerative hyperplasia in common variable immunodeficiency","volume":"33","author":"Fuss","year":"2013","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib41","doi-asserted-by":"crossref","first-page":"145ra06","DOI":"10.1126\/scitranslmed.3004140","article-title":"Inhibition\u00a0of\u00a0LTi\u00a0cell development by CD25 blockade is associated with decreased\u00a0intrathecal inflammation in multiple sclerosis","volume":"4","author":"Perry","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2015.09.013_bib42","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1084\/jem.20130351","article-title":"A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis","volume":"210","author":"Salimi","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2015.09.013_bib43","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/jid.2013.477","article-title":"Characterization of innate lymphoid cells in human skin and blood demonstrates\u00a0increase of NKp44+ ILC3 in psoriasis","volume":"134","author":"Villanova","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2015.09.013_bib44","first-page":"30","article-title":"Evaluation of the T helper 17 cell specific genes and the innate lymphoid cells counts in the peripheral blood of patients with the common variable immunodeficiency","volume":"19","author":"Ganjalikhani-Hakemi","year":"2014","journal-title":"J Res Med Sci"},{"key":"10.1016\/j.jaci.2015.09.013_bib45","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.1005641107","article-title":"Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity","volume":"107","author":"Cella","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2015.09.013_bib46","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ni.2002","article-title":"RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota","volume":"12","author":"Sawa","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2015.09.013_bib47","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1084\/jem.20140039","article-title":"Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders","volume":"211","author":"Perreau","year":"2014","journal-title":"J Exp Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674915013512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674915013512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:57:24Z","timestamp":1758790644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674915013512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0091674915013512"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2015.09.013","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2015.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}