{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:27:41Z","timestamp":1786991261420,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jaci.2016.02.032","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T18:33:43Z","timestamp":1462041223000},"page":"1319-1325.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Maternal plasma total neopterin and kynurenine\/tryptophan levels during pregnancy in relation to asthma development in the offspring"],"prefix":"10.1016","volume":"138","author":[{"given":"Maria C.","family":"Magnus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ystein","family":"Karlstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ivind","family":"Midtun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri E.","family":"H\u00e5berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gro","family":"Tunheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"Parr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Nafstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"London","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy M.","family":"Nilsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per M.","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenche","family":"Nystad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.02.032_bib1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.5588\/ijtld.14.0170","article-title":"Global burden of asthma among children","volume":"18","author":"Asher","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jaci.2016.02.032_bib2","doi-asserted-by":"crossref","first-page":"e10134","DOI":"10.1371\/journal.pone.0010134","article-title":"Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis","volume":"5","author":"Lim","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2016.02.032_bib3","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jaci.2014.12.1921","article-title":"Advances in pediatric asthma in 2014: Moving toward a population health perspective","volume":"135","author":"Szefler","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.032_bib4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1084\/jem.160.1.310","article-title":"Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma","volume":"160","author":"Huber","year":"1984","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.02.032_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/1389200024605082","article-title":"Neopterin as a marker for immune system activation","volume":"3","author":"Murr","year":"2002","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.jaci.2016.02.032_bib6","first-page":"1721","article-title":"Increased neopterin concentrations in patients with cancer: indicator of oxidative stress?","volume":"19","author":"Murr","year":"1999","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jaci.2016.02.032_bib7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.atherosclerosis.2008.04.047","article-title":"Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease","volume":"202","author":"Murr","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jaci.2016.02.032_bib8","first-page":"372","article-title":"Neopterin, a marker of cell-mediated immune activation in human pregnancy","volume":"36","author":"Fuith","year":"1991","journal-title":"Int J Fertil"},{"key":"10.1016\/j.jaci.2016.02.032_bib9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0024-3205(02)02304-4","article-title":"Longitudinal study of tryptophan degradation during and after pregnancy","volume":"72","author":"Schrocksnadel","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.jaci.2016.02.032_bib10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0873-2159(15)30459-1","article-title":"The evaluation of neopterin and antioxidants in long lasting asthma","volume":"12","author":"Mota Pinto","year":"2006","journal-title":"Rev Port Pneumol"},{"key":"10.1016\/j.jaci.2016.02.032_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2222.1991.tb01681.x","article-title":"Neopterin quantification in acute severe asthma","volume":"21","author":"Neale","year":"1991","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.02.032_bib12","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/resp.12089","article-title":"Non-invasive biomarkers in exacerbations of obstructive lung disease","volume":"18","author":"Warwick","year":"2013","journal-title":"Respirology"},{"key":"10.1016\/j.jaci.2016.02.032_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1399-3038.2005.00343.x","article-title":"Association between neopterin in cord blood, urinary neopterin in early childhood and the development of atopic dermatitis, asthma and hay fever","volume":"17","author":"Horak","year":"2006","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.02.032_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/CS20140392","article-title":"Role of indoleamine 2,3-dioxygenase in health and disease","volume":"129","author":"Yeung","year":"2015","journal-title":"Clin Sci"},{"key":"10.1016\/j.jaci.2016.02.032_bib15","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.4049\/jimmunol.170.12.5809","article-title":"Tryptophan catabolism and regulation of adaptive immunity","volume":"170","author":"Mellor","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.02.032_bib16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2016.02.032_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/83183","article-title":"Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy","volume":"2","author":"Mellor","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.02.032_bib18","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of allogeneic fetal rejection by tryptophan catabolism","volume":"281","author":"Munn","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jaci.2016.02.032_bib19","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.molimm.2005.06.022","article-title":"Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy","volume":"43","author":"Raitala","year":"2006","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2016.02.032_bib20","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1136\/thoraxjnl-2013-203728","article-title":"Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design","volume":"68","author":"van der Sluijs","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2016.02.032_bib21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/cea.12498","article-title":"Respiratory syncytial virus induces indoleamine 2,3-dioxygenase activity: a\u00a0potential novel role in the development of allergic disease","volume":"45","author":"Ajamian","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.02.032_bib22","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/ije\/dyl170","article-title":"Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa)","volume":"35","author":"Magnus","year":"2006","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaci.2016.02.032_bib23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-3016.2009.01062.x","article-title":"Self-selection and bias in a large prospective pregnancy cohort in Norway","volume":"23","author":"Nilsen","year":"2009","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.jaci.2016.02.032_bib24","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10654-006-9041-x","article-title":"The biobank of the Norwegian Mother and Child Cohort Study: a resource for the next 100 years","volume":"21","author":"Ronningen","year":"2006","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jaci.2016.02.032_bib25","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/rcm.4013","article-title":"Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography\/tandem mass spectrometry","volume":"23","author":"Midttun","year":"2009","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.jaci.2016.02.032_bib26","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1093\/clinchem\/35.12.2305","article-title":"Urinary neopterin concentrations vs total neopterins for clinical utility","volume":"35","author":"Fuchs","year":"1989","journal-title":"Clin Chem"},{"key":"10.1016\/j.jaci.2016.02.032_bib27","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3945\/jn.113.189738","volume":"144","author":"Midttun","year":"2014","journal-title":"J Nutr"},{"key":"10.1016\/j.jaci.2016.02.032_bib28","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jclinepi.2010.10.014","article-title":"High validity of mother-reported use of antiasthmatics among children: a comparison with a population-based prescription database","volume":"64","author":"Furu","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jaci.2016.02.032_bib29","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1530\/REP-10-0360","article-title":"A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system","volume":"141","author":"Warning","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.jaci.2016.02.032_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jri.2003.11.004","article-title":"Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta","volume":"61","author":"Kudo","year":"2004","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.jaci.2016.02.032_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/molehr\/8.4.385","article-title":"Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta","volume":"8","author":"Sedlmayr","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.jaci.2016.02.032_bib32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/imr.12187","article-title":"Innate immunity in the lung regulates the development of asthma","volume":"260","author":"DeKruyff","year":"2014","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2016.02.032_bib33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2174\/187152812800958951","article-title":"Interferon-gamma, pulmonary macrophages and airway responsiveness in asthma","volume":"11","author":"Kumar","year":"2012","journal-title":"Inflamm Allergy Drug Targets"},{"key":"10.1016\/j.jaci.2016.02.032_bib34","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1542\/peds.2014-0439","article-title":"Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma","volume":"134","author":"Forno","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2016.02.032_bib35","doi-asserted-by":"crossref","first-page":"w14036","DOI":"10.4414\/smw.2014.14036","article-title":"Childhood asthma: causes, risks, and protective factors; a\u00a0role of innate immunity","volume":"144","author":"Noutsios","year":"2014","journal-title":"Swiss Med Wkly"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916300859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916300859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:02:14Z","timestamp":1758790934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916300859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0091674916300859"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.02.032","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal plasma total neopterin and kynurenine\/tryptophan levels during pregnancy in relation to asthma development in the offspring","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.02.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}