{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:57:50Z","timestamp":1791424670431,"version":"4.3.3"},"reference-count":67,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"AllerGen NCE Inc"},{"DOI":"10.13039\/501100000182","name":"WorkSafeBC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015752","name":"BC Lung Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015752","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008002","name":"Vancouver Coastal Health Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.jaci.2016.02.038","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T15:10:32Z","timestamp":1462029032000},"page":"1690-1700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers"],"prefix":"10.1016","volume":"138","author":[{"given":"Christopher F.","family":"Rider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-555X","authenticated-orcid":false,"given":"Masatsugu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver P.","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Tebbutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Carlsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.02.038_bib1","series-title":"World Allergy Organization. World Allergy Organization (WAO) white book on allergy","author":"Pawankar","year":"2011"},{"key":"10.1016\/j.jaci.2016.02.038_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mrfmmm.2009.09.005","article-title":"Chronic inflammation and asthma","volume":"690","author":"Murdoch","year":"2010","journal-title":"Mutat Res"},{"key":"10.1016\/j.jaci.2016.02.038_bib3","unstructured":"Government of Canada SC. Asthma, by sex, provinces and territories (Number of persons). 2014. Available from: http:\/\/www.statcan.gc.ca\/tables-tableaux\/sum-som\/l01\/cst01\/health50a-eng.htm. Accessed April 2, 2015."},{"key":"10.1016\/j.jaci.2016.02.038_bib4","unstructured":"Global Initiative for Asthma. GINA Global Strategy for Asthma Management and\u00a0Prevention. 2014. Available from: http:\/\/www.ginasthma.org\/documents\/4. Accessed May 7, 2014."},{"key":"10.1016\/j.jaci.2016.02.038_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jaci.2010.07.030","article-title":"Environmental epigenetics of asthma: an update","volume":"126","author":"Ho","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1398-9995.2009.02244.x","article-title":"Is the prevalence of asthma declining? Systematic review of epidemiological studies","volume":"65","author":"Anandan","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.02.038_bib7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ccm.2012.07.003","article-title":"Respiratory health effects of ambient air pollution: an update","volume":"33","author":"Sava","year":"2012","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.jaci.2016.02.038_bib8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jaci.2011.09.025","article-title":"Does air pollution increase the effect of aeroallergens on hospitalization for asthma?","volume":"129","author":"Cakmak","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib9","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.rmed.2015.05.017","article-title":"Allergy and asthma: effects of the exposure to particulate matter and biological allergens","volume":"109","author":"Baldacci","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.02.038_bib10","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1056\/NEJMoa071535","article-title":"Respiratory effects of exposure to diesel traffic in persons with asthma","volume":"357","author":"McCreanor","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2016.02.038_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1289\/ehp.01109319","article-title":"Number concentration and size of particles in urban air: effects on spirometric lung function in adult asthmatic subjects","volume":"109","author":"Penttinen","year":"2001","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jaci.2016.02.038_bib12","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1183\/09031936.02.01402001","article-title":"Increased asthma medication use in association with ambient fine and ultrafine particles","volume":"20","author":"von Klot","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.02.038_bib13","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1289\/ehp.0800335","article-title":"Symptoms and medication use in children with asthma and traffic-related sources of fine particle pollution","volume":"117","author":"Gent","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jaci.2016.02.038_bib14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MCP.0b013e32834f0e2a","article-title":"Diesel exhaust particles and airway inflammation","volume":"18","author":"Ghio","year":"2012","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jaci.2016.02.038_bib15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/clim.2000.4921","article-title":"In\u00a0vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines RANTES, MIP-1\u03b1, and MCP-3 in humans","volume":"97","author":"Diaz-Sanchez","year":"2000","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib16","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.4049\/jimmunol.158.5.2406","article-title":"Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in\u00a0vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern","volume":"158","author":"Diaz-Sanchez","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib17","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0091-6749(99)70011-4","article-title":"Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa","volume":"104","author":"Diaz-Sanchez","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12989-014-0071-3","article-title":"Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics","volume":"11","author":"Jiang","year":"2014","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.jaci.2016.02.038_bib19","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.jaci.2011.11.033","article-title":"The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter","volume":"129","author":"Hirota","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib20","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1165\/rcmb.2011-0160OC","article-title":"Distinct microRNA expression in human airway cells of asthmatic donors identifies a novel asthma-associated gene","volume":"47","author":"Jardim","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2016.02.038_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-immunol-020711-075013","article-title":"microRNA regulation of inflammatory responses","volume":"30","author":"O\u2019Connell","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mrfmmm.2011.05.004","article-title":"Environmental chemicals and microRNAs","volume":"714","author":"Hou","year":"2011","journal-title":"Mutat Res Mol Mech Mutagen"},{"key":"10.1016\/j.jaci.2016.02.038_bib23","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1164\/rccm.201201-0027OC","article-title":"Airway epithelial miRNA expression is altered in asthma","volume":"186","author":"Solberg","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.02.038_bib24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/ACI.0000000000000147","article-title":"Role of microRNAs in allergic asthma: present and future","volume":"15","author":"Perry","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib25","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1513\/AnnalsATS.201303-070AW","article-title":"Subtypes of asthma defined by epithelial cell expression of messenger RNA and microRNA","volume":"10","author":"Woodruff","year":"2013","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jaci.2016.02.038_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/08958378.2011.562256","article-title":"The Air Pollution Exposure Laboratory (APEL) for controlled human exposure to diesel exhaust and other inhalants: characterization and comparison to existing facilities","volume":"23","author":"Birger","year":"2011","journal-title":"Inhal Toxicol"},{"key":"10.1016\/j.jaci.2016.02.038_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ni0305-223","article-title":"Air pollution and allergy: you are what you breathe","volume":"6","author":"Saxon","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib28","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nm.2737","article-title":"The airway epithelium in asthma","volume":"18","author":"Lambrecht","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2016.02.038_bib29","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.coi.2012.08.012","article-title":"Human airway epithelial cell innate immunity: relevance to asthma","volume":"24","author":"Hirota","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1186\/1471-2164-13-655","article-title":"Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge","volume":"13","author":"Yamamoto","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jaci.2016.02.038_bib31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1289\/ehp.1205963","article-title":"MicroRNA expression in response to controlled exposure to diesel exhaust: attenuation by the antioxidant N-acetylcysteine in a randomized crossover study","volume":"121","author":"Yamamoto","year":"2013","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jaci.2016.02.038_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/thoraxjnl-2015-207399","article-title":"Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study","volume":"71","author":"Carlsten","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2016.02.038_bib33","doi-asserted-by":"crossref","first-page":"D78","DOI":"10.1093\/nar\/gkt1266","article-title":"miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions","volume":"42","author":"Hsu","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2016.02.038_bib34","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.jaci.2016.02.038_bib35","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1093\/bioinformatics\/btl483","article-title":"GATHER: a systems approach to interpreting genomic signatures","volume":"22","author":"Chang","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2016.02.038_bib36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/gad.1399806","article-title":"Control of translation and mRNA degradation by miRNAs and siRNAs","volume":"20","author":"Valencia-Sanchez","year":"2006","journal-title":"Genes Dev"},{"key":"10.1016\/j.jaci.2016.02.038_bib37","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1038\/onc.2010.34","article-title":"Multiple microRNAs modulate p21Cip1\/Waf1 expression by directly targeting its 3\u2032 untranslated region","volume":"29","author":"Wu","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.jaci.2016.02.038_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cell.2010.03.009","article-title":"Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP","volume":"141","author":"Hafner","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2016.02.038_bib39","doi-asserted-by":"crossref","first-page":"736","DOI":"10.15252\/embr.201438480","article-title":"Genes, the environment and personalized medicine","volume":"15","author":"Carlsten","year":"2014","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jaci.2016.02.038_bib40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.anai.2014.07.019","article-title":"Air pollution and asthma: how can a public health concern inform the care of individual patients?","volume":"113","author":"North","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib41","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-065X.2011.01033.x","article-title":"Epithelial cells and airway diseases","volume":"242","author":"Proud","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2016.02.038_bib42","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.clim.2003.08.006","article-title":"Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects","volume":"109","author":"Li","year":"2003","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib43","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/1471-2458-11-532","article-title":"Modification by antioxidant supplementation of changes in human lung function associated with air pollutant exposure: a systematic review","volume":"11","author":"Tashakkor","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jaci.2016.02.038_bib44","unstructured":"Carlsten C. Diesel exhaust and mechanism of asthma\u2014full text view - ClinicalTrials.gov. 2012. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01699204?term=Christopher+Carlsten&rank=3. Accessed December 17, 2015."},{"key":"10.1016\/j.jaci.2016.02.038_bib45","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/toxsci\/kfu040","article-title":"Anti-oxidant N-acetylcysteine diminishes diesel exhaust-induced increased airway responsiveness in person with airway hyper-reactivity","volume":"139","author":"Carlsten","year":"2014","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jaci.2016.02.038_bib46","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.pharmthera.2009.11.004","article-title":"Transcriptional responses to oxidative stress: pathological and toxicological implications","volume":"125","author":"Ma","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jaci.2016.02.038_bib47","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.immuni.2005.02.004","article-title":"Granzyme A\u00a0induces caspase-independent mitochondrial damage, a required first step for apoptosis","volume":"22","author":"Martinvalet","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.02.038_bib48","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1165\/ajrcmb.19.3.3143","article-title":"Combined nasal challenge with diesel exhaust particles and allergen induces in\u00a0vivo IgE isotype switching","volume":"19","author":"Fujieda","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2016.02.038_bib49","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1164\/ajrccm.161.2.9905052","article-title":"Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways","volume":"161","author":"Salvi","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.02.038_bib50","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1164\/rccm.200404-532OC","article-title":"Effects of allergen challenge on airway epithelial cell gene expression","volume":"171","author":"Lilly","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.02.038_bib51","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/0091-6749(92)90462-B","article-title":"Mast cells and eosinophils in the\u00a0allergic mucosal response to allergen challenge: changes in distribution and signs of activation in relation to symptoms","volume":"90","author":"Juliusson","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib52","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1067\/mai.2003.1654","article-title":"Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma","volume":"112","author":"Langley","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib53","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1067\/mai.2001.113046","article-title":"Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways","volume":"107","author":"Braunstahl","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib54","doi-asserted-by":"crossref","first-page":"e5889","DOI":"10.1371\/journal.pone.0005889","article-title":"MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy","volume":"4","author":"Williams","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2016.02.038_bib55","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.coi.2015.07.006","article-title":"MicroRNA regulation of allergic inflammation and asthma","volume":"36","author":"Pua","year":"2015","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib56","doi-asserted-by":"crossref","first-page":"L1129","DOI":"10.1152\/ajplung.00348.2013","article-title":"Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects","volume":"306","author":"Fry","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2016.02.038_bib57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/CCO.0b013e32835b639e","article-title":"p21WAF1 and tumourigenesis: 20 years after","volume":"25","author":"Warfel","year":"2013","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.jaci.2016.02.038_bib58","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrrev.2010.01.009","article-title":"Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response","volume":"704","author":"Cazzalini","year":"2010","journal-title":"Mutat Res Mutat Res"},{"key":"10.1016\/j.jaci.2016.02.038_bib59","doi-asserted-by":"crossref","first-page":"L1118","DOI":"10.1152\/ajplung.00232.2011","article-title":"Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement","volume":"302","author":"Alrashdan","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2016.02.038_bib60","doi-asserted-by":"crossref","first-page":"e75813","DOI":"10.1371\/journal.pone.0075813","article-title":"Performance comparison of digital microRNA profiling technologies applied on human breast cancer cell lines","volume":"8","author":"Knutsen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2016.02.038_bib61","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.cell.2011.09.049","article-title":"Regulation of the probability of mouse odorant receptor gene choice","volume":"147","author":"Khan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2016.02.038_bib62","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nbt1385","article-title":"Direct multiplexed measurement of gene expression with color-coded probe pairs","volume":"26","author":"Geiss","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jaci.2016.02.038_bib63","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1465-9921-13-89","article-title":"Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways","volume":"13","author":"Fry","year":"2012","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2016.02.038_bib64","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jaci.2008.10.002","article-title":"Innate microbial sensors and their relevance to allergy","volume":"122","author":"Liu","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib65","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/ACI.0b013e328357cc55","article-title":"Air pollution, genetics, and allergy: an update","volume":"12","author":"Carlsten","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jaci.2011.11.004","article-title":"Effects of air pollutants on innate immunity: the role of Toll-like receptors and nucleotide-binding oligomerization domain\u2013like receptors","volume":"129","author":"Bauer","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.02.038_bib67","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1710-1492-2-3-109","article-title":"The difficult-to-control asthmatic: a systematic approach","volume":"2","author":"Le","year":"2006","journal-title":"Allergy Asthma Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491630149X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491630149X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:02:34Z","timestamp":1758790954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167491630149X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S009167491630149X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.02.038","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.02.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}